Oxadiazoles and thiadiazoles: Novel α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5454-5465

  Kashtoh, Hamdy ^a   Hussain, Shafqat ^b   Khan, Ajmal ^b   Saad, Syed Muhammad ^b   Khan, Jalaluddin A J ^a   Khan, Khalid Mohammed ^b   Perveen, Shahnaz ^c   Choudhary, M Iqbal ^a,b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c PCSIR LABORATORIES COMPLEX   (Pakistan)

Author keywords

Diabetes; Oxadiazoles; Post prandial hyperglycemia; Thiadiazoles; Glucosidase inhibition

Indexed keywords

1 (3 CHLOROPHENYL) 2 (5 PHENYL 1,3,4 OXADIAZOL 2 YLTHIO)ETHANONE; 1 (3 CHLOROPHENYL) 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (3 FLUOROPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (3 FLUOROPHENYL) 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (3 HYDROXYPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (3 HYDROXYPHENYL) 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (3 METHOXYPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (3 NITROPHENYL) 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (3,4 DICHLOROPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (4 BROMOPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (4 BROMOPHENYL) 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (4 CHLOROPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 (4 CHLOROPHENYL) 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 (4 METHOXYPHENYL) 2 [(5 PHENYL 1,3,4 OXADIAZOL 2 YL)SULFANYL] 1 ETHANONE; 1 [1,1' BIPHENYL] 4 YL 2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 1 [1,1' BIPHENYL] 4 YL 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 ETHANONE; 2 [5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YLTHIO] 1 (3 HYDROXYPHENYL)ETHANONE; 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (2 METHOXYPHENYL) 1 ETHANONE; 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (3 FLUOROPHENYL) 1 ETHANONE; 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (3 METHOXYPHENYL) 1 ETHANONE; 2 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (4 METHOXYPHENYL) 1 ETHANONE; 2 [[5 [4 (BENZYLOXY)PHENYL] 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (2 METHOXYPHENYL) 1 ETHANONE; 2 [[5 [4 (BENZYLOXY)PHENYL] 1,3,4 OXADIAZOL 2 YL]SULFANYL] 1 (4 METHOXYPHENYL) 1 ETHANONE; 3 [2 [[5 (3 PYRIDINYL) 1,3,4 OXADIAZOL 2 YL]SULFANYL]ACETYL] 2H CHROMEN 2 ONE; ALPHA GLUCOSIDASE INHIBITOR; CARBONATE DEHYDRATASE II; OXADIAZOLE DERIVATIVE; PHOSPHODIESTERASE I; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ALPHA GLUCOSIDASE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; GLYCOSIDASE INHIBITOR; PHOSPHODIESTERASE INHIBITOR;

3T3 CELL LINE; ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC PATIENT; DISSOCIATION CONSTANT; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG INDICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; HYPERGLYCEMIA; IC50; IN VITRO STUDY; MTT ASSAY; NONHUMAN; POSTPRANDIAL STATE; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

3T3 CELLS; ALPHA-GLUCOSIDASES; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDE HYDROLASE INHIBITORS; MICE; MOLECULAR STRUCTURE; OXADIAZOLES; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84907529441     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.032     Document Type: Article

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