Design, synthesis and anti-diabetic activity of thiadiazole-based thioglycosides as SGLT2 inhibitors

Chinese Journal of Organic Chemistry

Volumn 30, Issue 6, 2010, Pages 849-859

  Wang, Zhifeng ^a   Zhao, Guilong ^b   Liu, Wei ^b   Wang, Yuli ^b   Shao, Hua ^b   Xu, Weiren ^b   Tian, Laijin ^a  

^a QUFU NORMAL UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Anti hyperglycemic activity; Sglt2 inhibitor; Synthesis; Thiadiazole; Thioglycoside

Indexed keywords

EID: 77956580713     PISSN: 02532786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Li, G.-R.; Li, L.-L.; Wang, J.-H. China Pharm. 2008, 19(5), 383 (in Chinese).
2. Liu, Y.-W. Foreign Med. Sci. Sect. Pharm. 2005, 32(2), 109 (in Chinese).
3. Meng, M.; Ellsworth, B. A.; Nirschl, A. A.; McCann, P. J.; Patel, M.; Girotra, R. N.; Wu, G.; Sher, P. M.; Morrison, E. P.; Biller, S. A.; Zahler, R.; Deshpande, P. P.; Pullockaran, A.; Hagan, D. L.; Morgan, N.; Taylor, J. R.; Obermeier, M. T.; Humphreys, W. G.; Khanna, A.; Discenza, L.; Robertson, J. M.; Wang, A.; Han, S.; Wetterau, J. R.; Janovitz, E. B.; Flint, O. P.; Whaley, J. M.; Washburn, W. N. J. Med. Chem. 2008, 57, 1145.
4. Ellsworth, B.; Washburn, W. N.; Sher, P. M.; Wu, G; Meng, W. WO 2001027128, 2001
5. [Chem. Abstr. 2001, 134, 281069].
6. Washburn, W. N. US 6555519 2003
7. [Chem. Abstr. 2001, 135, 273164].
8. Washburn, W N; Sher, P. M.; Wu, G. US 6683056 2005
9. [Chem. Abstr. 2001, 135, 273163].
10. Fushimi, N.; Fujikura, H.; Nishimura, T.; Katauno, K.; Isaji, M. US 7294618 2007
11. [Chem. Abstr. 2002, 137, 201524].
12. Tsujihara, K.; Hongu, M.; Saito, K.; Inamasu, M.; Arakawa, K.; Oku, A.; Matsumoto, M. Chem. Pharm. Bull. 1996, 44, 1174.
13. Katsuno, K.; Fujimori, Y.; Takemura, Y.; Hiratochi, M.; Itoh, F.; Komatsy, Y.; Fujikura, H.; Isaji, M. J. Pharmacol. Exp. Ther. 2007, 320, 323.
14. Gao, Y. L.; Zhao, G. L.; Liu, W.; Wang, Y. L.; Xu, W. R.; Wang, J. W. Chin. J. Chem. to be published.
15. Zhang, X. Y.; Urbanski, M.; Patel, M.; Cox, G. G.; Zeck, R. E.; Bian, H. Y.; Conway, B. R.; Beavers, M. P.; Rybczynski, P. J.; Demarest, K. T. Bioorg. Med. Chem. Lett. 2006, 16, 1696.
16. Ellsworth, B. A.; Meng, M.; Patel, M.; Girotra, R. N.; Wu, G; Sher, P. M.; Hagan, D. L.; Obermeier, M. T.; Humphreys, W. G.; Robertson, J. M.; Wang, A.; Han, S.; Waldron, T. L.; Morgan, N. N.; Whaley, J. M.; Washburn, W. N. Bioorg. Med. Chem. Lett. 2008, 18, 4770.
17. Chen, J.; Liu, F.; Song, B. A.; Yang, S.; Hu, D. Y.; Jin, L. H.; Chen, Z.; Xue, W. Chin. J. Org. Chem. 2008, 28, 894 (in Chinese).
18. Zhao, G. L.; Yu, Z. Y.; Li, Y.; Pang, L. N.; Wang, J. W. Chin. J. Chem. 2008, 26, 158.