Human cytomegalovirus tegument protein pp65 is detected in all intra- And extra-axial brain tumours independent of the tumour type or grade

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Libard, Sylwia ^a,b   Popova, Svetlana N ^a,b   Amini, Rose Marie ^a,b   Kärjä, Vesa ^c   Pietiläinen, Timo ^c   M Hämäläinen, Kirşi ^c   Sundström, Christer ^a,b   Hesselager, Göran ^a   Bergqvist, Michael ^d,e   Ekman, Simon ^b   Zetterling, Maria ^a   Smits, Anja ^b   Nilsson, Pelle ^a   Pfeifer, Susan ^a   De Stahl, Teresita Diaz ^f   Enblad, Gunilla ^b   Ponten, Fredrik ^b   Alafuzoff, Irina ^a,b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d GÄVLE HOSPITAL   (Sweden)

^e UMEÅ UNIVERSITY   (Sweden)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; CYTOMEGALOVIRUS ANTIGEN PP65; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PHOSPHOPROTEIN;

ADULT; AGE; AGED; ANTIBODY LABELING; ANTIGEN RETRIEVAL; ARTICLE; AUTOPSY; CANCER GRADING; CELL LABELING; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENDER; GLIOMA; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MENINGIOMA; NEUROMODULATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; ADOLESCENT; BRAIN TUMOR; CYTOMEGALOVIRUS; GLIOBLASTOMA; ISOLATION AND PURIFICATION; LYMPHOMA; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

HUMAN HERPESVIRUS 5;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; COHORT STUDIES; CYTOMEGALOVIRUS; FEMALE; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MALE; MEDULLOBLASTOMA; MENINGIOMA; MIDDLE AGED; NEOPLASM GRADING; PHOSPHOPROTEINS; VIRAL MATRIX PROTEINS; YOUNG ADULT;

EID: 84907486464     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108861     Document Type: Article

References (59)

1. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, et al. (2002) Human cytomegalovirus infection and expression in human malignant glioma.Cancer Res 62: 3347-3350.
2. Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, et al. (2002) Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360: 1557-1563.
3. Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS (2003) High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170: 998-1002.
4. Zafiropoulos A, Tsentelierou E, Billiri K, Spandidos DA (2003) Human herpes viruses in non-melanoma skin cancers. Cancer Lett 198: 77-81.
5. Sehic D, Forslund O, Sanden E, Mengelbier LH, Karlsson J, et al. (2013) Absence of Epstein-Barr and cytomegalovirus infection in neuroblastoma cells by standard detection methodologies. Pediatr Blood Cancer 60: E91 -93.
6. Wolmer-Solberg N, Baryawno N, Rahbar A, Fuchs D, OdebergJ, et al. (2013) Frequent detection of human cytomegalovirus in neuroblastoma: a novel therapeutic target? IntJ Cancer 133: 2351-2361.
7. Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, OdebergJ, et al. (2011) Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest 121: 4043-4055.
8. Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R (2008) Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol 116: 79-86.
9. Lau SK, Chen YY, Chen WG, Diamond DJ, Mamelak AN, et al. (2005) Lack of association of cytomegalovirus with human brain tumors. Mod Pathol 18: 838 -843.
10. Sabatier J, Uro-Coste E, Pommepuy I, Labrousse F, Allart S, et al. (2005) Detection of human cytomegalovirus genome and gene products in central nervous system tumours. Br J Cancer 92: 747-750.
11. Mitchell DA, Xie W, Schmitding R, Learn C, Friedman A, et al. (2008) Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro Oncol 10: 10 -18.
12. Poltermann S, Schlehofer B, Steindorf K, Schnitzler P, Geletneky K, et al. (2006) Lack of association of herpesviruses with brain tumors. J Neurovirol 12: 90-99.
13. Rahbar A, Orrego A, Peredo I, Dzabic M, Wolmer-Solberg N, et al. (2013) Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. J Clin Virol 57: 36M2.
14. Ranganathan P, Clark PA, Kuo JS, Salamat MS, Kalejta RF (2012) Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol 86: 854-864.
15. Stragliotto G, Rahbar A, Solberg NW, Lilja A, Taher C, et al. (2013) Effects of valganciclovir as an add-on therapy in patients with cytomegalovirus-positive glioblastoma: a randomized, double-blind, hypothesis-generating study. IntJ Cancer 133: 1204-1213.
16. Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, et al. (2013) Cidofovir: a novel antitumor agent for glioblastoma. Clin Cancer Res 19: 6473 -6483.
17. Griffiths PD, Emery VC, Milne R (2009) Cytomegalovirus. In: Richman DD, Whidey RJ, Hayden FG, editors. Clinical Virology. Washington, DC: American Society for Microbiology. 475-506.
18. Landolfo S, Gariglio M, Gribaudo G, Lembo D (2003) The human cytomegalovirus. Pharmacol Ther 98: 269-297.
19. Bresnahan WA, Shenk TE (2000) UL82 virion protein activates expression of immediate early viral genes in human cytomegalovirus-infected cells. Proc Nad Acad Sci U S A 97: 14506-14511.
20. Trgovcich J, Cebulla C, Zimmerman P, Sedmak DD (2006) Human cytomegalovirus protein pp71 disrupts major histocompatibility complex class I cell surface expression. J Virol 80: 951-963.
21. Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, et al. (2012) Consensus on the role of human cytomegalovirus in glioblastoma. Neuro Oncol 14: 246-255.
22. Gandhi MK, Khanna R (2004) Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis 4: 725-738.
23. Ludwig A, Hengel H (2009) Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. Euro Surveill 14: 26-32.
24. Mustakangas P, Sarna S, Ammala P, Muttilainen M, Koskela P, et al. (2000) Human cytomegalovirus seroprevalence in three socioeconomically different urban areas during the first trimester: a population-based cohort study. IntJ Epidemiol 29: 587-591.
25. Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, et al. (2010) HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal 3: ra58.
26. Barami K (2010) Oncomodulatory mechanisms of human cytomegalovirus in gliomas. J Clin Neurosci 17: 819-823.
27. Cobbs CS (2011) Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis. Herpesviridae 2: 10.
28. Cobbs CS (2013) Cytomegalovirus and brain tumor: epidemiology, biology and therapeutic aspects. Curr Opin Oncol 25: 682-688.
29. Michaelis M, Baumgarten P, Mittelbronn M, Driever PH, Doerr HW, et al. (2011) Oncomodulation by human cytomegalovirus: novel clinical findings open new roads. Med Microbiol Immunol 200: 1-5.
30. Michaelis M, Doerr HW, Cinatl J Jr (2009) Oncomodulation by human cytomegalovirus: evidence becomes stronger. Med Microbiol Immunol 198: 79 -81.
31. Michaelis M, Kotchetkov R, Vogel JU, Doerr HW, Cinatl J Jr (2004) Cytomegalovirus infection blocks apoptosis in cancer cells. Cell Mol Life Sei 61: 1307-1316.
32. Michelson S (1999) Human cytomegalovirus escape from immune detection. Intervirology 42: 301-307.
33. Soroceanu L, Matlaf L, Bezrookove V, Harkins L, Martinez R, et al. (2011) Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. Cancer Res 71: 6643-6653.
34. Karja V, Sandeil PJ, Kauppinen T, Alafuzoff I (2010) Does protein expression predict recurrence of benign World Health Organization grade I meningioma? Hum Pathol 41: 199-207.
35. Nord H, Pfeifer S, Nilsson P, Sandgren J, Popova S, et al. (2012) Novel amplifications in pediatric medulloblastoma identified by genome-wide copy number profiling. J Neurooncol 107: 37 -49.
36. Popova SN, Bergqvist M, Dimberg A, Edqvist PH, Ekman S, et al. (2014) Subtyping of gliomas of various WHO grades by the application of immunohistochemistry. Histopathology 64: 365-379.
37. Kauppinen T, Martikainen P, Alafuzoff I (2006) Human postmortem brain tissue and 2-mm tissue microarrays. Appl Immunohistochem Mol Morphol 14: 353-359.
38. KononenJ, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, et al. (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens.Nat Med 4: 844-847.
39. Kampf C, Bergman J, Oksvold P, Asplund A, Navani S, et al. (2012) A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas. BMC Med 10: 103.
40. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, et al. (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma charac-terized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17: 98-110.
41. Stein H, Warnke BA, Chan WC, Jaffe ES, ChanJKC, et al. (2008) Diffuse large B-cell lymphoma, not otherwise specified In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4 ed. Lyon: International Agency for Research on Cancer. 233-237.
42. Colomo L, Lopez-Guillermo A, Perales M, Rives S, Martinez A, et al. (2003) Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood 101: 78-84.
43. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, et al. (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103: 275-282.
44. Lucas KG, Bao L, Bruggeman R, Dunham K, Specht C (2011) The detection of CMV pp65 and IE1 in glioblastoma multiforme. J Neurooncol 103: 231-238.
45. Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I (2010) Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain. J Alzheimers Dis 20: 1015-1028.
46. Cobbs CS, Soroceanu L, Denham S, Zhang W, Britt WJ, et al. (2007) Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol 85: 271 -280.
47. D'Amico F, Skarmoutsou E, Stivala F (2009) State of the art in antigen retrieval for immunohistochemistry. J Immunol Methods 341: 1-18.
48. McNicol AM, Richmond JA (1998) Optimizing immunohistochemistry: antigen retrieval and signal amplification. Histopathology 32: 97-103.
49. Shi SR, Cote BJ, Taylor CR (2001) Antigen retrieval immunohistochemistry and molecular morphology in the year 2001. Appl Immunohistochem Mol Morphol 9: 107-116.
50. Straat K, Liu C, Rahbar A, Zhu Q, Liu L, et al. (2009) Activation of telomerase by human cytomegalovirus. J Nad Cancer Inst 101: 488-197.
51. Karlsson C, Karlsson MG (2011) Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides. J Histochem Cytochem 59: 1113-1121.
52. Leong TY, Cooper K, Leong AS (2010) Immunohistology - past, present, and future. Adv Anat Pathol 17: 404M48.
53. Ramos-Vara JA, Miller MA (2014) When tissue antigens and antibodies get along: revisiting the technical aspects of immunohistochemistry - the red, brown, and blue technique. Vet Pathol 51: 42-87.
54. Ding D, Han S, Wang Z, Guo Z, Wu A (2014) Does the existence of HCMV components predict poor prognosis in glioma? J Neurooncol 116: 515-522.
55. Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20: 202-213.
56. Liu XF, Wang X, Yan S, Zhang Z, Abecassis M, et al. (2013) Epigenetic control of cytomegalovirus latency and reactivation. Viruses 5: 1325-1345.
57. Reeves M, Sinclair J (2013) Regulation of human cytomegalovirus transcription in latency: beyond the major immediate-early promoter. Viruses 5: 1395-1413.
58. Taher C, de Boniface J, Mohammad AA, Religa P, Hartman J, et al. (2013) High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes. PLoS One 8: e56795.
59. Soderberg-Naucler C, Rahbar A, Stragliotto G (2013) Survival in patients with glioblastoma receiving valganciclovir. N Engl J Med 369: 985-986.