메뉴 건너뛰기




Volumn 74, Issue 18, 2014, Pages 5229-5243

ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADAM9 PROTEIN, HUMAN; CDCP1 PROTEIN, HUMAN; CELL ADHESION MOLECULE; DASATINIB; DEXAMETHASONE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PLASMINOGEN ACTIVATOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE; TUMOR PROTEIN;

EID: 84907486062     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2995     Document Type: Article
Times cited : (71)

References (47)
  • 2
    • 27644546807 scopus 로고    scopus 로고
    • Brain metastases: Epidemiology and pathophysiology
    • Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J Neurooncol 2005;75:5-14.
    • (2005) J Neurooncol , vol.75 , pp. 5-14
    • Gavrilovic, I.T.1    Posner, J.B.2
  • 3
    • 33845406670 scopus 로고    scopus 로고
    • Update in the treatment of brain metastases from lung cancer
    • Schwer AL, Gaspar LE. Update in the treatment of brain metastases from lung cancer. Clin Lung Cancer 2006;8:180-6.
    • (2006) Clin Lung Cancer , vol.8 , pp. 180-186
    • Schwer, A.L.1    Gaspar, L.E.2
  • 5
    • 63449101161 scopus 로고    scopus 로고
    • The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain
    • Grinberg-Rashi H, Ofek E, Perelman M, Skarda J, Yaron P, Hajduch M, et al. The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. Clin Cancer Res 2009;15:1755-61.
    • (2009) Clin Cancer Res , vol.15 , pp. 1755-1761
    • Grinberg-Rashi, H.1    Ofek, E.2    Perelman, M.3    Skarda, J.4    Yaron, P.5    Hajduch, M.6
  • 7
    • 0028820623 scopus 로고
    • ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: Multipotential functions in cell-cell and cell-matrix interactions
    • Wolfsberg TG, Primakoff P, Myles DG, White JM. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol 1995;131:275-8.
    • (1995) J Cell Biol , vol.131 , pp. 275-278
    • Wolfsberg, T.G.1    Primakoff, P.2    Myles, D.G.3    White, J.M.4
  • 8
    • 0033933982 scopus 로고    scopus 로고
    • Meltrin γ (ADAM-9) mediates cellular adhesion through α (6) β (1) integrin, leading to a marked induction of fibroblast cell motility
    • Nath D, Slocombe PM, Webster A, Stephens PE, Docherty AJ, Murphy G. Meltrin γ (ADAM-9) mediates cellular adhesion through α (6) β (1) integrin, leading to a marked induction of fibroblast cell motility. J Cell Sci 2000;113(Pt 12):2319-28.
    • (2000) J Cell Sci , vol.113 , pp. 2319-2328
    • Nath, D.1    Slocombe, P.M.2    Webster, A.3    Stephens, P.E.4    Docherty, A.J.5    Murphy, G.6
  • 9
    • 0032908446 scopus 로고    scopus 로고
    • Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion
    • Iba K, Albrechtsen R, Gilpin BJ, Loechel F, Wewer UM. Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion. Am J Pathol 1999;154:1489-501.
    • (1999) Am J Pathol , vol.154 , pp. 1489-1501
    • Iba, K.1    Albrechtsen, R.2    Gilpin, B.J.3    Loechel, F.4    Wewer, U.M.5
  • 11
    • 11144356553 scopus 로고    scopus 로고
    • ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma
    • Grutzmann R, Luttges J, Sipos B, Ammerpohl O, Dobrowolski F, Alldinger I, et al. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Br J Cancer 2004;90:1053-8.
    • (2004) Br J Cancer , vol.90 , pp. 1053-1058
    • Grutzmann, R.1    Luttges, J.2    Sipos, B.3    Ammerpohl, O.4    Dobrowolski, F.5    Alldinger, I.6
  • 13
    • 33750307163 scopus 로고    scopus 로고
    • Oxidative stress induces ADAM9 protein expression in human prostate cancer cells
    • Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, et al. Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res 2006;66:9519-26.
    • (2006) Cancer Res , vol.66 , pp. 9519-9526
    • Sung, S.Y.1    Kubo, H.2    Shigemura, K.3    Arnold, R.S.4    Logani, S.5    Wang, R.6
  • 14
    • 0031226737 scopus 로고    scopus 로고
    • Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
    • Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R, et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997;17:353-60.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 353-360
    • Chu, Y.W.1    Yang, P.C.2    Yang, S.C.3    Shyu, Y.C.4    Hendrix, M.J.5    Wu, R.6
  • 15
    • 70349299843 scopus 로고    scopus 로고
    • Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival
    • Sher YP, Tzeng TF, Kan SF, Hsu J, Xie X, Han Z, et al. Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival. Oncogene 2009;28:3286-95.
    • (2009) Oncogene , vol.28 , pp. 3286-3295
    • Sher, Y.P.1    Tzeng, T.F.2    Kan, S.F.3    Hsu, J.4    Xie, X.5    Han, Z.6
  • 16
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002;30:207-10.
    • (2002) Nucleic Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 17
    • 58149343905 scopus 로고    scopus 로고
    • Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression
    • Lee ES, Son DS, Kim SH, Lee J, Jo J, Han J, et al. Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression. Clin Cancer Res 2008;14:7397-404.
    • (2008) Clin Cancer Res , vol.14 , pp. 7397-7404
    • Lee, E.S.1    Son, D.S.2    Kim, S.H.3    Lee, J.4    Jo, J.5    Han, J.6
  • 18
    • 79953331205 scopus 로고    scopus 로고
    • Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas
    • Matsuyama Y, Suzuki M, Arima C, Huang QM, Tomida S, Takeuchi T, et al. Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas. Mol Carcinog 2011;50:301-9.
    • (2011) Mol Carcinog , vol.50 , pp. 301-309
    • Matsuyama, Y.1    Suzuki, M.2    Arima, C.3    Huang, Q.M.4    Tomida, S.5    Takeuchi, T.6
  • 20
    • 80052836856 scopus 로고    scopus 로고
    • Integrated analyses of copy number variations and gene expression in lung adenocarcinoma
    • Lu TP, Lai LC, Tsai MH, Chen PC, Hsu CP, Lee JM, et al. Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. PLoS ONE 2011;6:e24829.
    • (2011) PLoS ONE , vol.6 , pp. e24829
    • Lu, T.P.1    Lai, L.C.2    Tsai, M.H.3    Chen, P.C.4    Hsu, C.P.5    Lee, J.M.6
  • 21
    • 77958069025 scopus 로고    scopus 로고
    • Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women
    • Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, et al. Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev 2010;19:2590-7.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2590-2597
    • Lu, T.P.1    Tsai, M.H.2    Lee, J.M.3    Hsu, C.P.4    Chen, P.C.5    Lin, C.W.6
  • 22
    • 75049084643 scopus 로고    scopus 로고
    • The role of chemotherapy in the management of newly diagnosed brain metastases: A systematic review and evidencebased clinical practice guideline
    • Mehta MP, Paleologos NA, Mikkelsen T, Robinson PD, Ammirati M, Andrews DW, et al. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidencebased clinical practice guideline. J Neurooncol 2010;96:71-83.
    • (2010) J Neurooncol , vol.96 , pp. 71-83
    • Mehta, M.P.1    Paleologos, N.A.2    Mikkelsen, T.3    Robinson, P.D.4    Ammirati, M.5    Andrews, D.W.6
  • 23
    • 79952072017 scopus 로고    scopus 로고
    • Preclinical approaches to study the biology and treatment of brain metastases
    • Cruz-Munoz W, Kerbel RS. Preclinical approaches to study the biology and treatment of brain metastases. Semin Cancer Biol 2011;21:123-30.
    • (2011) Semin Cancer Biol , vol.21 , pp. 123-130
    • Cruz-Munoz, W.1    Kerbel, R.S.2
  • 24
    • 34249317254 scopus 로고    scopus 로고
    • Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain
    • Palmieri D, Bronder JL, Herring JM, Yoneda T, Weil RJ, Stark AM, et al. Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res 2007;67:4190-8.
    • (2007) Cancer Res , vol.67 , pp. 4190-4198
    • Palmieri, D.1    Bronder, J.L.2    Herring, J.M.3    Yoneda, T.4    Weil, R.J.5    Stark, A.M.6
  • 25
    • 35649025769 scopus 로고    scopus 로고
    • CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma
    • Uekita T, Jia L, Narisawa-Saito M, Yokota J, Kiyono T, Sakai R. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 2007;27:7649-60.
    • (2007) Mol Cell Biol , vol.27 , pp. 7649-7660
    • Uekita, T.1    Jia, L.2    Narisawa-Saito, M.3    Yokota, J.4    Kiyono, T.5    Sakai, R.6
  • 26
    • 0037468568 scopus 로고    scopus 로고
    • Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
    • Hooper JD, Zijlstra A, Aimes RT, Liang H, Claassen GF, Tarin D, et al. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 2003;22:1783-94.
    • (2003) Oncogene , vol.22 , pp. 1783-1794
    • Hooper, J.D.1    Zijlstra, A.2    Aimes, R.T.3    Liang, H.4    Claassen, G.F.5    Tarin, D.6
  • 29
    • 84865637021 scopus 로고    scopus 로고
    • Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells
    • Casar B, He Y, Iconomou M, Hooper JD, Quigley JP, Deryugina EI. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene 2012;31:3924-38.
    • (2012) Oncogene , vol.31 , pp. 3924-3938
    • Casar, B.1    He, Y.2    Iconomou, M.3    Hooper, J.D.4    Quigley, J.P.5    Deryugina, E.I.6
  • 30
    • 77956210264 scopus 로고    scopus 로고
    • Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ
    • He Y, Wortmann A, Burke LJ, Reid JC, Adams MN, Abdul-Jabbar I, et al. Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ. J Biol Chem 2010;285:26162-73.
    • (2010) J Biol Chem , vol.285 , pp. 26162-26173
    • He, Y.1    Wortmann, A.2    Burke, L.J.3    Reid, J.C.4    Adams, M.N.5    Abdul-Jabbar, I.6
  • 31
    • 84861213311 scopus 로고    scopus 로고
    • T-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes
    • Niego B, Freeman R, Puschmann TB, Turnley AM, Medcalf RL. t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes. Blood 2012;119:4752-61.
    • (2012) Blood , vol.119 , pp. 4752-4761
    • Niego, B.1    Freeman, R.2    Puschmann, T.B.3    Turnley, A.M.4    Medcalf, R.L.5
  • 32
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the bloodbrain barrier via the LDL receptor-related protein
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the bloodbrain barrier via the LDL receptor-related protein. J Clin Invest 2003;112:1533-40.
    • (2003) J Clin Invest , vol.112 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 33
    • 84874763834 scopus 로고    scopus 로고
    • Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms
    • Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, Patel B, et al. Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Oncogene 2013;32:1316-29.
    • (2013) Oncogene , vol.32 , pp. 1316-1329
    • Law, M.E.1    Corsino, P.E.2    Jahn, S.C.3    Davis, B.J.4    Chen, S.5    Patel, B.6
  • 34
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl) - Piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl) - piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004;47:6658-61.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3    Norris, D.4    Barrish, J.C.5    Behnia, K.6
  • 35
    • 56449100212 scopus 로고    scopus 로고
    • Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells
    • Buettner R, Mesa T, Vultur A, Lee F, Jove R. Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells. Mol Cancer Res 2008;6:1766-74.
    • (2008) Mol Cancer Res , vol.6 , pp. 1766-1774
    • Buettner, R.1    Mesa, T.2    Vultur, A.3    Lee, F.4    Jove, R.5
  • 36
    • 79955470772 scopus 로고    scopus 로고
    • The "A Disintegrin and Metalloproteases" ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
    • Saftig P, Reiss K. The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential? Eur J Cell Biol 2011;90:527-35.
    • (2011) Eur J Cell Biol , vol.90 , pp. 527-535
    • Saftig, P.1    Reiss, K.2
  • 37
    • 0023873934 scopus 로고
    • Structure-function analysis with tissue-type plasminogen activator. Effect of deletion of NH2-terminal domains on its biochemical and biological properties
    • Kalyan NK, Lee SG, Wilhelm J, Fu KP, Hum WT, Rappaport R, et al. Structure-function analysis with tissue-type plasminogen activator. Effect of deletion of NH2-terminal domains on its biochemical and biological properties. J Biol Chem 1988;263:3971-8.
    • (1988) J Biol Chem , vol.263 , pp. 3971-3978
    • Kalyan, N.K.1    Lee, S.G.2    Wilhelm, J.3    Fu, K.P.4    Hum, W.T.5    Rappaport, R.6
  • 38
    • 0035407354 scopus 로고    scopus 로고
    • Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: An immunohistochemical study
    • Ito Y, Takeda T, Higashiyama S, Sakon M, Wakasa KI, Tsujimoto M, et al. Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: an immunohistochemical study. Oncol Rep 2001;8:903-7.
    • (2001) Oncol Rep , vol.8 , pp. 903-907
    • Ito, Y.1    Takeda, T.2    Higashiyama, S.3    Sakon, M.4    Wakasa, K.I.5    Tsujimoto, M.6
  • 39
    • 84894103794 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia
    • Ray KC, Moss ME, Franklin JL, Weaver CJ, Higginbotham J, Song Y, et al. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Oncogene 2014;33:823-31.
    • (2014) Oncogene , vol.33 , pp. 823-831
    • Ray, K.C.1    Moss, M.E.2    Franklin, J.L.3    Weaver, C.J.4    Higginbotham, J.5    Song, Y.6
  • 40
    • 2942569101 scopus 로고    scopus 로고
    • Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor
    • Fischer OM, Hart S, Gschwind A, Prenzel N, Ullrich A. Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol 2004;24:5172-83.
    • (2004) Mol Cell Biol , vol.24 , pp. 5172-5183
    • Fischer, O.M.1    Hart, S.2    Gschwind, A.3    Prenzel, N.4    Ullrich, A.5
  • 41
    • 84858986330 scopus 로고    scopus 로고
    • The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration
    • Dong Y, He Y, de Boer L, Stack MS, Lumley JW, Clements JA, et al. The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration. J Biol Chem 2012;287:9792-803.
    • (2012) J Biol Chem , vol.287 , pp. 9792-9803
    • Dong, Y.1    He, Y.2    De Boer, L.3    Stack, M.S.4    Lumley, J.W.5    Clements, J.A.6
  • 42
    • 0026396004 scopus 로고
    • Regulation of human tissue-type plasminogen activator gene transcription by epidermal growth factor and 30, 50-cyclic adenosine monophosphate
    • Medcalf RL, Schleuning WD. Regulation of human tissue-type plasminogen activator gene transcription by epidermal growth factor and 30, 50-cyclic adenosine monophosphate. Mol Endocrinol 1991;5:1773-9.
    • (1991) Mol Endocrinol , vol.5 , pp. 1773-1779
    • Medcalf, R.L.1    Schleuning, W.D.2
  • 43
    • 38949105094 scopus 로고    scopus 로고
    • EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells
    • Paugh BS, Paugh SW, Bryan L, Kapitonov D, Wilczynska KM, Gopalan SM, et al. EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells. FASEB J 2008;22:455-65.
    • (2008) FASEB J , vol.22 , pp. 455-465
    • Paugh, B.S.1    Paugh, S.W.2    Bryan, L.3    Kapitonov, D.4    Wilczynska, K.M.5    Gopalan, S.M.6
  • 44
    • 33847373884 scopus 로고    scopus 로고
    • Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1α, and C/EBPα
    • Liao H, Hyman MC, Lawrence DA, Pinsky DJ. Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1α, and C/EBPα. FASEB J 2007;21:935-49.
    • (2007) FASEB J , vol.21 , pp. 935-949
    • Liao, H.1    Hyman, M.C.2    Lawrence, D.A.3    Pinsky, D.J.4
  • 45
    • 0032953135 scopus 로고    scopus 로고
    • Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer
    • de Witte JH, Sweep CG, Klijn JG, Grebenschikov N, Peters HA, Look MP, et al. Prognostic value of tissue-type plasminogen activator (tPA) and its complex with the type-1 inhibitor (PAI-1) in breast cancer. Br J Cancer 1999;80:286-94.
    • (1999) Br J Cancer , vol.80 , pp. 286-294
    • De Witte, J.H.1    Sweep, C.G.2    Klijn, J.G.3    Grebenschikov, N.4    Peters, H.A.5    Look, M.P.6
  • 46
    • 0141817889 scopus 로고    scopus 로고
    • High preoperative plasma concentration of tissue plasminogen activator (tPA) is an independent marker for shorter overall survival in patients with ovarian cancer
    • Borgfeldt C, Bendahl PO, Ferno M, Casslen B. High preoperative plasma concentration of tissue plasminogen activator (tPA) is an independent marker for shorter overall survival in patients with ovarian cancer. Gynecol Oncol 2003;91:112-7.
    • (2003) Gynecol Oncol , vol.91 , pp. 112-117
    • Borgfeldt, C.1    Bendahl, P.O.2    Ferno, M.3    Casslen, B.4
  • 47
    • 0025995880 scopus 로고
    • Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer
    • Janicke F, Schmitt M, Graeff H. Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer. Semin Thromb Hemost 1991;17:303-12.
    • (1991) Semin Thromb Hemost , vol.17 , pp. 303-312
    • Janicke, F.1    Schmitt, M.2    Graeff, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.