Effect of interference from hemolysis, icterus and lipemia on routine pediatric clinical chemistry assays

Clinica Chimica Acta

Volumn 438, Issue , 2015, Pages 241-245

  Agarwal, Shweta ^a   Vargas, German ^a   Nordstrom, Cristina ^a   Tam, Estella ^a   Buffone, Gregory J ^a   Devaraj, Sridevi ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Hemolysis; Icterus; Indices; Interference; Lipemia; Pediatric

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CERULOPLASMIN; CHORIONIC GONADOTROPIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CREATINE KINASE; CREATINE KINASE MB; ESTRADIOL; FERRIC ION; FERRITIN; FOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HAPTOGLOBIN; HEPATITIS B CORE ANTIGEN; HYDROCORTISONE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTRALIPID; MAGNESIUM ION; POTASSIUM ION; TRIACYLGLYCEROL LIPASE; VITAMIN D; COMPLEMENT; HEMOGLOBIN; IMMUNOGLOBULIN; LIPID;

ARTICLE; CLINICAL CHEMISTRY; DISEASE SEVERITY; ESTRADIOL BLOOD LEVEL; HEMOLYSATE; HEMOLYSIS; HUMAN; HYPERLIPIDEMIA; JAUNDICE; LABORATORY DEVICE; PEDIATRICS; ARTIFACT; BIOASSAY; BLOOD; CHEMISTRY; PROCEDURES; STANDARDS;

ARTIFACTS; BILIRUBIN; BIOLOGICAL ASSAY; CHEMISTRY, CLINICAL; COMPLEMENT SYSTEM PROTEINS; ESTRADIOL; HAPTOGLOBINS; HEMOGLOBINS; HEMOLYSIS; HUMANS; HYPERLIPIDEMIAS; IMMUNOGLOBULINS; JAUNDICE; LIPIDS; VITAMIN D;

EID: 84907485552     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2014.08.008     Document Type: Article

References (14)

1. Witte D.L., VanNess S.A., Angstadt D.S., Pennell B.J. Errors, mistakes, blunders, outliers, or unacceptable results: how many?. Clin Chem 1997, 43(8 Pt 1):1352-1356.
2. Dimeski G. Interference testing. Clin Biochem Rev 2008, 29(Suppl. 1):S43-S48.
3. Saibaba K.S., Bhaskar M.V., Rao P.V., Ramana G.V., Dakshinamurty K.V. Interferences in clinical chemistry analysis. Indian J Clin Biochem 1998, 13:55-62.
4. Steen G., Klerk A., Laan K., Eppens E.F. Evaluation of the interference due to hemoglobin, bilirubin and lipids on Immulite 2500 assays: A practical approach. Ann Clin Biochem. 2011, 201;48(Pt 2):170-175.
5. Kroll M.H., Elin R.J. Interferences with clinical laboratory analyses. Clin Chem 1994, 40:1996-2005.
6. Sonntag O. Haemolysis as an interference factor in clinical chemistry. J Clin Chem Clin Biochem 1986, 24:127-139.
7. Kroll M.H. Evaluating interference caused by lipemia. Clin Chem 2004, 50:1968-1969.
8. Ji J.Z., Meng Q.H. Evaluation of the interference of hemoglobin, bilirubin, and lipids on Roche Cobas 6000 assays. Clin Chim Acta 2011, 412(17-18):1550-1553.
9. Koseoglu M., Hur A., Atay A., Cuhadar S. Effects of hemolysis interferences on routine biochemistry parameters. Biochem Med (Zagreb) 2011, 21:79-85.
10. Roberts C.M., Cotten S.W. Cyclodextrin removal of lipemic interference: an attractive alternative to ultracentrifugation for satellite laboratories. Arch Pathol Lab Med 2013, 137:1027-1028.
11. Sen Gupta P., Sharma M., Timms P.M. Laboratory samples deemed 'unsuitable for analysis' can be diagnostically useful. Clin Med 2013, 13:309-311.
12. Automated serum indices measurement on Vitros 5600 integrated system. [Internet] Available from:. http://www.orthoclinical.com/en-us/ProductInformation/ClinicalLaboratories/Pages/VitrosLabCentral-Vitros5600.aspx.
13. Lippi G., Luca Salvagno G., Blanckaert N., Giavarina D., Green S., Kitchen S., et al. Multicenter evaluation of the hemolysis index in automated clinical chemistry systems. Clin Chem Lab Med 2009, 47:934-939.
14. Vermeer H.J., Thomassen E., de Jonge N. Automated processing of serum indices used for interference detection by the laboratory information system. Clin Chem 2005, 51:244-247.