Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Watanabe, Shin ^a   Horie, Takahiro ^a   Nagao, Kazuya ^a   Kuwabara, Yasuhide ^a   Baba, Osamu ^a   Nishi, Hitoo ^a   Sowa, Naoya ^a   Narazaki, Michiko ^a   Matsuda, Tetsuya ^a   Takemura, Genzou ^b   Wada, Hiromichi ^c   Hasegawa, Koji ^c   Kimura, Takeshi ^a   Ono, Koh ^a  

^a KYOTO UNIVERSITY   (Japan)

^b ASAHI UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE TRIPHOSPHATE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; CREATINE PHOSPHATE; MYOSIN HEAVY CHAIN ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; MYH6 PROTEIN, MOUSE; MYOSIN HEAVY CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENERGY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART FAILURE; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; LEFT VENTRICULAR REMODELING; MALE; MITOCHONDRION; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNAL TRANSDUCTION; TRANSVERSE AORTIC CONSTRICTION; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HEART VENTRICLE; METABOLISM; MORTALITY; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROMOTER REGION; TRANSGENIC MOUSE; UPREGULATION;

MUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEART FAILURE; HEART VENTRICLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOSIN HEAVY CHAINS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; UP-REGULATION; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84907459123     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108201     Document Type: Article

References (32)

1. Clapham DE (2007) Calcium signaling. Cell 131: 1047-1058.
2. Chin D, Means AR (2000) Calmodulin: A prototypical calcium sensor. Trends Cell Biol 10: 322-328.
3. Colbran RJ (2004) Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity. J Neurosci 24: 8404-8409.
4. Tokumitsu H, Enslen H, Soderling TR (1995) Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J Biol Chem 270: 19320-19324.
5. Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, et al. (1998) Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem 273: 31880-31889.
6. Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, et al. (2008) Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 7: 377-388.
7. Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, et al. (2008) Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell Physiol 215: 733-742.
8. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, et al. (2010) Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 464: 1313-1319.
9. Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, et al. (2005) Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMPactivated protein kinase in mammalian cells. Cell Metab 2: 21-33.
10. Cho A, Haruyama N, Kulkarni AB (2009) Generation of transgenic mice. Curr Protoc Cell Biol Chapter 19: Unit 1911.
11. Date MO, Morita T, Yamashita N, Nishida K, Yamaguchi O, et al. (2002) The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model. J Am Coll Cardiol 39: 907-912.
12. Inuzuka Y, Okuda J, Kawashima T, Kato T, Niizuma S, et al. (2009) Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice. Circulation 120: 1695-1703.
13. Ellis JM, Mentock SM, Depetrillo MA, Koves TR, Sen S, et al. (2011) Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. Mol Cell Biol 31: 1252-1262.
14. Kawashima T, Inuzuka Y, Okuda J, Kato T, Niizuma S, et al. (2011) Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. J Mol Cell Cardiol 51: 1026-1036.
15. Tokumitsu H, Iwabu M, Ishikawa Y, Kobayashi R (2001) Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms. Biochemistry 40: 13925-13932.
16. Subramaniam A, Jones WK, Gulick J, Wert S, Neumann J, et al. (1991) Tissuespecific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 266: 24613-24620.
17. Handschin C, Spiegelman BM (2008) The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 454: 463-469.
18. Murakami Y, Zhang Y, Cho YK, Mansoor AM, Chung JK, et al. (1999) Myocardial oxygenation during high work states in hearts with postinfarction remodeling. Circulation 99: 942-948.
19. Sartoretto JL, Kalwa H, Shiroto T, Sartoretto SM, Pluth MD, et al. (2012) Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes. PLoS One 7: e44627.
20. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, et al. (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228.
21. Racioppi L, Means AR (2012) Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem 287: 31658-31665.
22. Tsutsui H, Kinugawa S, Matsushima S (2011) Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol 301: H2181-2190.
23. Lopaschuk GD, Rebeyka IM, Allard MF (2002) Metabolic modulation: A means to mend a broken heart. Circulation 105: 140-142.
24. Sambandam N, Lopaschuk GD, Brownsey RW, Allard MF (2002) Energy metabolism in the hypertrophied heart. Heart Fail Rev 7: 161-173.
25. Depre C, Vanoverschelde JL, Taegtmeyer H (1999) Glucose for the heart. Circulation 99: 578-588.
26. Zhang P, Hu X, Xu X, Fassett J, Zhu G, et al. (2008) AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension 52: 918-924.
27. Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, et al. (2012) Deletion of CaMKK2 from the liver lowers blood glucose and improves wholebody glucose tolerance in the mouse. Mol Endocrinol 26: 281-291.
28. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, et al. (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106: 847-856.
29. Vega RB, Huss JM, Kelly DP (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20: 1868-1876.
30. Huss JM, Kopp RP, Kelly DP (2002) Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and-gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem 277: 40265-40274.
31. Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, et al. (2004) Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stagedependent manner. Circ Res 94: 525-533.
32. Arany Z, He H, Lin J, Hoyer K, Handschin C, et al. (2005) Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab 1: 259-271.