The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Biological Psychology

Volumn 103, Issue , 2014, Pages 158-166

  Castanho, Teresa Costa ^a,b,c   Moreira, Pedro Silva ^a,b,c   Portugal Nunes, Carlos ^a,b,c   Novais, Ashley ^a,b,c   Costa, Patrício Soares ^a,b,c   Palha, Joana Almeida ^a,b,c   Sousa, Nuno ^a,b,c   Santos, Nadine Correia ^a,b,c  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c Clinical Academic Center Braga   (Portugal)

Author keywords

Executive function; Memory; Nutrition; Quality of life; Sleep

Indexed keywords

ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROLACTIN; TESTOSTERONE; GONADOTROPIN; SEX HORMONE;

ADULT; AGED; AGING; ARTICLE; COGNITION; COGNITIVE DEFECT; COMMUNITY ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DIGIT SYMBOL SUBSTITUTION TEST; EXECUTIVE FUNCTION; FEMALE; GERIATRIC DEPRESSION SCALE; GERIATRIC PATIENT; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MOOD; NUTRITIONAL STATUS; PHENOTYPIC VARIATION; QUALITY OF LIFE; RATING SCALE; SCORING SYSTEM; SEX DIFFERENCE; WECHSLER INTELLIGENCE SCALE; WELLBEING; WORKING MEMORY; AFFECT; BLOOD; MIDDLE AGED; SATISFACTION; VERY ELDERLY;

AFFECT; AGED; AGED, 80 AND OVER; COGNITION; CROSS-SECTIONAL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; GONADAL STEROID HORMONES; GONADOTROPINS, PITUITARY; HUMANS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PERSONAL SATISFACTION; PROLACTIN; SEX FACTORS; TESTOSTERONE;

EID: 84907451764     PISSN: 03010511     EISSN: 18736246     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2014.08.015     Document Type: Article

References (56)

1. Aleman A., De Vries W.R., Koppeschaar H.P., Osman-Dualeh M., Verhaar H.J., Samson M.M., et al. Relationship between circulating levels of sex hormones and insulin-like growth factor-1 and fluid intelligence in older men. Experimental Aging Research 2001, 27:283-291.
2. Alfaro S., Serra-Prat M., Palomera E., Falcón I., Cadenas I., Boquet X., et al. Hormonal determinants of depression and cognitive function in independently living elders. Endocrinología y Nutrición 2008, 55:396-401.
3. Barrett-Connor E., Goodman-Gruen D. Cognitive function and endogenous sex hormones in older women. Journal of the American Geriatrics Society 1999, 47:1289-1293.
4. Ben-Jonathan N., Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocrine Reviews 2001, 22:724-763.
5. Bimonte-Nelson H.A., Acosta J.I., Talboom J.S. Neuroscientists as cartographers: mapping the crossroads of gonadal hormones, memory and age using animal models. Molecules 2010, 15:6050-6105.
6. Bole-Feysot C., Goffin V., Edery M., Binart N., Kelly P.A. Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocrine Reviews 1998, 19:225-268.
7. Boss L., Kang D., Marcus M., Bergstrom N. Endogenous sex hormones and cognitive function in older adults: A systematic review. Western Journal of Nursing Research 2013, 20:1-39.
8. Buysse D.I., Reynolds C.F., Monk T.H., Berman S.R., Kupfe D.J. The Pittsburgh sleep quality índex: A new instrument for psychiatric practice and research. Psychiatry Research 1988, 28:193-213.
9. Costa P.S., Santos N.C., Cunha P., Palha J.A., Sousa N. The use of Bayesian latent class cluster models to classify patterns of cognitive performance in healthy ageing. PLOS ONE 2013, 8:e71940.
10. Davis S.R., Panjari M., Stanczyk F.Z. DHEA replacement for postmenopausal women. The Journal of Clinical Endocrinology & Metabolism 2011, 96:1642-1653.
11. Duncko R., Johnson L., Merikangas K., Grillon C. Working memory performance after acute exposure to the cold pressor stress in healthy volunteers. Neurobiology of Learning and Memory 2009, 91:377-381.
12. Farr S.A., Banks W.A., Uezu K., Gaski F.S., Morley J.E. DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice. Life Sciences 2004, 75:2775-2785.
13. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. The Journal of Clinical Endocrinology and Metabolism 2002, 87:589-598.
14. Fuller S.J., Tan R.S., Martins R.N. Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions. Journal of Alzheimer's Disease 2007, 12:129-142.
15. Goldstein J.M., Holsen L.M., Handa R., Tobet S. Sex differences in HPA and HPG axes dysregulation in major depressive disorder: The role of shared brain circuitry between hormones and mood. Multiple origins of sex differences in brain: Research and perspectives in endocrine interactions 2013, 139-163. Springer, Berlin/Heidelberg. D.W. Pfaff, Y. Christen (Eds.).
16. Guigoz Y., Vellas B., Garry P.J. Assessing the nutritional status of the elderly: The mini nutritional assessment as part of the geriatric evaluation. Nutrition Reviews 1996, 54:S59-S65.
17. Harsh V., Meltzer-Brody S., Rubinow D.R., Schmidt P.J. Reproductive aging, sex steroids, and mood disorders. Harvard Review Of Psychiatry 2009, 17:87-102.
18. Henry J.F., Sherwin B. Hormones and cognitive functioning during late pregnancy and postpartum: A longitudinal study. Behavioral Neuroscience 2012, 126:73-85.
19. Hermann M., Berger P. Hormone replacement in the aging male?. Experimental Gerontology 1999, 34:923-933.
20. Hyde Z., Flicker L., Almeida O.P., McCaul K.A., Jamrozik K., Hankey G.J., et al. Higher luteinizing hormone is associated with poor memory recall: The health in men study. Journal of Alzheimer's Disease 2010, 19:943-951.
21. Janowsky J.S. Thinking with your gonads: Testosterone and cognition. Trends in Cognitive Sciences 2006, 10:77-82.
22. Lajud N., Gonzalez-Zapien R., Roque A., Tinajero E., Valdez J.J., Clap C., et al. Prolactin administration during early postnatal life decreases hippocampal and olfactory bulb neurogenesis and results in depressive-like behavior in adulthood. Hormones and Behavior 2013, 64:781-789.
23. Lei Z.M., Rao C.V., Kornyei J.L., Licht P., Hiatt E.S. Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 1993, 132:2262-2270.
24. Lisansky J., Fava G., Buckman M., Kellner R., Fava M., Zielezny M., et al. Prolactin, amitriptyline, and recovery from depression. Psychopharmacology 1984, 84:331-335.
25. Luetters C., Huang M.H., Seeman T., Buckwalter G., Meyer P.M., Avis N.E., et al. Menopause transition stage and endogenous estradiol and follicle-stimulating hormone levels are not related to cognitive performance: Cross-sectional results from the study of women's health across the nation (SWAN). Journal of Women's Health 2007, 16:331-344.
26. Lunn P., Austin S., Prentice A., Whitehea G. The effect of improved nutrition on plasma prolactin concentrations and postpartum infertility in lactating Gambian women. The American Journal of Clinical Nutrition 1984, 39:227-235.
27. Maggio M., De Vita F., Fisichella A., Colizzi E., Provenzano S., Lauretani F., et al. DHEA and cognitive function in the elderly. The Journal of Steroid Biochemistry and Molecular Biology 2014, 10.1016/j.jsbmb.2014.03.014.
28. Martínez-Jabaloyas J.M., Queipo-Zaragozá A., Ferrandis-Cortes C., Queipo-Zaragozá J.A., Gil-Salom M., Chuan-Nuez P. Relationships between sex hormone levels in men over 50 years of age and body composition, bone quality, and quality of life. Actas Urológicas Españolas 2011, 35:515-522.
29. Matousek R.H., Sherwin B.B. Sex steroid hormones and cognitive functioning in healthy, older men. Hormones and Behavior 2010, 57:352-359.
30. Moffat S.D., Zonderman A.B., Metter E.J., Blackman M.R., Harman S.M., Resnick S.M. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. The Journal of Clinical Endocrinology and Metabolism 2002, 87:5001-5007.
31. Morsink L.F., Vogelzangs N., Nicklas B.J., Beekman A.T., Satterfield S., Rubin S.M., et al. Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: Results from the Health ABC study. Psychoneuroendocrinology 2007, 32:874-883.
32. Murphy P.J., Campbell S.S. Sex hormones, sleep, and core body temperature in older postmenopausal women. Sleep 2007, 30:1788-1794.
33. OECD Country statistical profile: Portugal (Organisation for Economic Co-operation and Development iLibrary Web site) 2012, 10.1787/csp-prt-Table-2011-1-en.
34. Paulo A.C., Sampaio A., Santos N.C., Costa P.S., Cunha P., Zihl J., et al. Patterns of cognitive performance in healthy ageing in northern Portugal: A cross-sectional analysis. PLoS ONE 2011, 6:1-9.
35. Prull M.W., Gabrieli J.D., Bunge S.A. Age-related changes in memory: A cognitive neuroscience perspective. The handbook of aging and cognition 2000, 91-153. Psychological Press, New York. F.I.M. Craik, T.A. Salthouse (Eds.).
36. Rathna K.U., Padma K. Dehydroepiandrosterone levels and cognitive function in aging. International Journal of Medical Research & Health Sciences 2013, 2:101-106.
37. Ravaglia G., Forti P., Maiol F., Boschi F., Bernardi M., Pratelli L., et al. The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. The Journal of Clinical Endocrinology and Metabolism 1996, 81:1173-1178.
38. Rodrigues M.A., Verdile G., Foster J.K., Hogervorst E., Joesbury K., Dhaliwal S., et al. Gonadotropins and cognition in older women. Journal of Alzheimer's Disease 2008, 13:267-274.
39. Santos N.C., Costa P.S., Cunha P., Cotter J., Sampaio A., Zihl J., et al. Mood is a key determinant of cognitive performance in community-dwelling older adults: A cross-sectional analysis. Age (Dordr) 2013, 35:1983-1993.
40. Santos N.C., Costa P.S., Cunha P., Portugal-Nunes C., Amorim L., Cotter J., et al. Clinical, physical and lifestyle variables and relationship with cognition and mood in aging: A cross-sectional analysis of distinct educational groups. Frontiers in Aging Neuroscience 2014, 6:21.
41. Sowers M.F., Zheng H., Kravitz H.M., Matthews K., Bromberger J.T., Gold E.B., et al. Sex steroid hormone profiles are related to sleep measures from polysomnography and the Pittsburgh Sleep Quality Index. Sleep 2008, 31:1339-1349.
42. Torner L., Tinajero E., Lajud N., Quintanar-Stephano A., Olvera-Cortes E. Hyperprolactinemia impairs object recognition without altering spatial learning in male rats. Behavioural Brain Research 2013, 252:32-39.
43. Vaz Serra A., Canavarro M.C., Simões M.R., Pereira M., Gameiro S., Quartilho M.J., et al. Estudos psicométricos do instrumento de avaliação da qualidade de vida da organização mundial de saúde (WHOQOL-100) para português de Portugal. Psiquiatria Clinica 2006, 27:31-40.
44. Walker T.L., Vukovic J., Koudijs M.M., Blackmore D.G., Mackay E.W., Sykes A.M., et al. Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS ONE 2012, 7:e44371.
45. Wang Y., Chan G.L.Y., Holden J.E., Dobko T., Mak E., Schulzer M., et al. Age-dependent decline of dopamine D1 receptors in human brain: A PET study. Synapse 1998, 30:56-61.
46. Webber K.M., Perry G., Smith M.A., Casadesus G. The contribution of luteinizing hormone to Alzheimer disease pathogenesis. Journal of Clinical Medicine Research 2007, 5:177-183.
47. Wolf O.T., Kirschbaum C. Actions of dehydroepiandrosterone and its sulfate in the central nervous system: Effects on cognition and emotion in animals and humans. Brain Research 1999, 30:264-288.
48. Wolf O.T., Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Hormones and Behavior 2002, 41:259-266.
49. Wong S.Y.S., Leung J.C., Kwok T., Ohlsson C., Vandenput L., Leung P.C., et al. Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: Results from a large study. Asian Journal of Andrology 2011, 13:898-902.
50. Yaffee K., Barnes D., Lindquist K., Cauley J., Simonsick E.M., Penninx B., et al. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiology of Aging 2007, 28:171-178.
51. Yaffee K., Lui L.Y., Zmuda J., Cauley J. Sex hormones and cognitive function in older men. Journal of the American Geriatrics Society 2002, 50:707-712.
52. Yang F., Tao J., Xu L., Zhao N., Chen J., Chen W., et al. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: No correlation with plasma corticosterone. Neuroreport 2014, 25:100-104.
53. Yang Y.K., Chiu N.T., Chen C.C., Chen M., Yeh T.L., Lee I.H. Correlation between fine motor activity and striatal dopamine D2 receptor density in patients with schizophrenia and healthy controls. Psychiatry Research Neuroimaging 2003, 123:191-197.
54. Yeap B.B., Almeida O.P., Hyde Z., Chubb S.A., Hankey G.J., Jamrozik K., et al. Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health in Men Study. Clinical Endocrinology 2008, 68:404-412.
55. Zeidan M., Igoe S., Linnman C., Vitalo A., Levine J., Klibanski A., et al. Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats. Biological Psychiatry 2011, 70:920-927.
56. Zjacic-Rotkvic V., Kavur L., Cigrovski-Berkovic M. Hormones and aging. Acta Clinica Croatica 2010, 49:549-554.