Elimination of B-RAF in Oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth

Journal of Biological Chemistry

Volumn 289, Issue 39, 2014, Pages 26804-26816

  Zanucco, Emanuele ^a   El Nikhely, Nefertiti ^b   Götz, Rudolf ^c,d   Weidmann, Katharina ^c,e   Pfeiffer, Verena ^c,f   Savai, Rajkumar ^b   Seeger, Werner ^b   Ullrich, Axel ^a   Rapp, Ulf R ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^e BSL BIOSERVICE Scientific Laboratories GmbH   (Germany)

^f UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELL SIGNALING;

COMPLEX PROCESSES; LUNG TUMOR; MAPK SIGNALING; SIGNAL INTENSITIES; TUMOR GROWTH; TUMORIGENESIS; TYPE II;

TUMORS;

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; SERINE; BRAF PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B RAF GENE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME ACTIVATION; GENE ACTIVATION; GENE INACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOMA; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; MOUSE; MUTATION; NONHUMAN; ONCOGENE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH; ADENOMA; ANIMAL; CELL TRANSFORMATION; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; HUMAN; LUNG ALVEOLUS; LUNG TUMOR; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; TRANSGENIC MOUSE;

ADENOMA; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; PULMONARY ALVEOLI; RESPIRATORY MUCOSA;

EID: 84907450571     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.558999     Document Type: Article

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