Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Cytokine

Volumn 68, Issue 1, 2014, Pages 23-31

  De la Torre, Alejandra ^a   Pfaff, Alexander W ^b   Grigg, Michael E ^c   Villard, Odile ^b   Candolfi, Ermanno ^b   Gomez Marin, Jorge E ^d  

^a UNIVERSIDAD DEL ROSARIO   (Colombia)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNIVERSIDAD DEL QUINDÍO   (Colombia)

Author keywords

Colombia; Intraocular cytokines; Th2; Toxoplasma gondii; Uveitis

Indexed keywords

CYTOKINE; CYTOKINOME; EOTAXIN; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RANTES; UNCLASSIFIED DRUG; VASCULOTROPIN; SIGNAL PEPTIDE;

ADULT; AGED; ANTIBODY PRODUCTION; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CLINICAL ARTICLE; COLOMBIAN; CONTROLLED STUDY; DISEASE SEVERITY; ETHNICITY; FEMALE; HUMAN; INFLAMMATION; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; SEROTYPE; SYMPTOMATOLOGY; TH1 CELL; TH17 CELL; TH2 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS; UVEITIS; VERY ELDERLY; CASE CONTROL STUDY; EYE; METABOLISM; PROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; AQUEOUS HUMOR; CASE-CONTROL STUDIES; CYTOKINES; EYE; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PROSPECTIVE STUDIES; TOXOPLASMOSIS, OCULAR;

EID: 84907432899     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.03.005     Document Type: Article

References (41)

1. de-la-Torre A., López-Castillo C.A., Gómez-Marín J.E. Incidence and clinical characteristics in a Colombian cohort of ocular toxoplasmosis. Eye (Lond) 2009, 23:1090-1093.
2. Pfaff A., de-la-Torre A., Rochet E., Brunet J., Sabou M., Sauer A., et al. New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. Int J Parasitol 2014, 44:99-107. 10.1016/j.ijpara.2013.09.00.
3. Lacomba M.S., Martin C.M., Chamond C., Galena J.M.G., Omar M., Esterez C. Aqueous and serum interferon gamma, interleukin (IL-2, IL-4 and IL-10) in patients with uveitis. Arch Ophthalmol 2000, 118:768-772.
4. Ooi K.G., Galatowicz G., Calder V.L., Lightman S.L. Cytokines and chemokines in uveitis: is there a correlation with clinical phenotype?. Clin Med Res 2006, 4:294-309.
5. Ang M., Cheung G., Vania M., Chen J., Yang H., Li J., et al. Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis. Mol Vis 2012, 18:565-573.
6. Lahmar I., Abou-Bacar A., Abdelrahman T., Guinard M., Babba H., Ben Yahia S., et al. Cytokine profiles in toxoplasmic and viral uveitis. J Infect Dis 2009, 199:1239-1249.
7. Sauer A., Pfaff A.W., Villard O., et al. Interleukin 17A as an effective target for anti-inflammatory and antiparasitic treatment of toxoplasmic uveitis. J Infect Dis 2012, 206:1319-1329.
8. Sibley L.D., Ajioka J.W. Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol 2008, 62:329-351.
9. Gilbert R.E., Freeman K., Lago E.G., Bahia-Oliveira L.M., Tan H.K., Wallon M., et al. European Multicentre Study on Congenital Toxoplasmosis (EMSCOT). Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Negl Trop Dis 2008, 2(8):e277.
10. de-la-Torre A., Sauer A., Bourcier T., Speeg-Schatz C., Ballonzoli L., Ajzenberg D., et al. Severe South American ocular toxoplasmosis is associated with decreased IFN-γ/IL-17A and increased IL-6/IL-13 intraocular levels. PLoS Negl Trop Dis 2013, 7(11):e2541. 10.1371/journal.pntd.000254.
11. Garweg J.G., de Groot-Mijnes J.D., Montoya J.G. Diagnostic approach to ocular toxoplasmosis. Ocul Immunol Inflamm 2011, 19:255-261.
12. Villard O., Cimon B., Franck J., Fricker-Hidalgo H., Godineau N., Houze S., et al. Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis. Network from the French National Reference Center for Toxoplasmosis. Diagn Microbiol Infect Dis 2012, 73:231-235.
13. de-la-Torre A., Rios-Cadavid A.C., Cardozo-García C.M., Gomez-Marín J.E. Frequency and factors associated with recurrences of ocular toxoplasmosis in a referral centre in Colombia. Br J Ophthalmol 2009, 93(8):1001-1004.
14. Deschenes J., Murray P.I., Rao N.A., Nussenblatt R.B. International Uveitis Study Group (IUSG): clinical classification of uveitis. Ocul Immunol Inflamm 2008, 16:1-2.
15. McLeod R., Boyer K.M., Lee D., Mui E., Wroblewski K., Karrison T., et al. Toxoplasmosis study group. Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009). Clin Infect Dis 2012, 54:1595-1605. 10.1093/cid/cis25.
16. Stein-Streilein J. Immune regulation and the eye. Trends Immunol 2008, 29:548-554. 10.1016/j.it.2008.08.002.
17. Bharadwaj A.S., Appukuttan B., Wilmarth P.A., Pan Y., Stempel A.J., Chipps T.J., et al. Role of the retinal vascular endothelial cell in ocular disease. Prog Retin Eye Res 2013, 32:102-180.
18. Shin W.H., Lee D.Y., Park K.W., Kim S.U., Yang M.S., Joe E.H., et al. Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo. Glia 2004, 15:142-152.
19. Fisson S., Ouakrim H., Touitou V., Baudet S., Ben Abdelwahed r., Donnou S., et al. Cytokine profile in human eyes: contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis. PLoS One 2013, 8(2):e52385. 10.1371/journal.pone.0052385.
20. Dutra M.S., Béla S.R., Peixoto-Rangel A.L., Fakiola M., Cruz A.G., Gazzinelli A., et al. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. J Infect Dis 2013, 207:152-163. 10.1093/infdis/jis640.
21. Dodds E.M., Holland G.N., Stanford M.R., Yu F., Siu W.O., Shah K.H., et al. Intraocular inflammation associated with ocular toxoplasmosis: relationships at initial examination. Am J Ophthalmol 2008, 146:856-865.
22. Rosowski E.E., Lu D., Julien L., Rodda L., Gaiser R.A., Jensen K.D., et al. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J Exp Med 2011, 208:195-212.
23. Gallego C., Saavedra C., Gómez Marín J.E. Direct genotyping of animal and human isolates of Toxoplasma gondii from Colombia (South America). Acta Tropica 2006, 97:161-167.
24. Fekkar A., Ajzenberg D., Bodaghi B., Touafek F., Le Hoang P., Delmas J., et al. Direct genotyping of Toxoplasma gondii in ocular fluid samples from 20 patients with ocular toxoplasmosis: predominance of type II in France. J Clin Microbiol 2011, 49:1513-1537.
25. Sánchez V., de-la-Torre A., Gómez Marín J.E. Characterization of ROP18 alleles in human toxoplasmosis. Parasitol Int 2014, 63:463-469. 10.1016/j.parint.2013.10.01.
26. Gupta S., Chiplunkar S., Kim C., Yel L., Gollapudi S. Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytes. Mech Ageing Dev 2003, 124:503-509.
27. Nolan Y., Maher F.O., Martin D.S., Clarke R.M., Brady M.T., Bolton A.E., et al. Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus. J Biol Chem 2005, 280:9354-9362.
28. Li S.P., Miller R.A. Age-associated decline in IL-4 production by murine T lymphocytes in extended culture. Cell Immunol 1993, 151:187-195.
29. Spear W., Chan D., Coppens I., Johnson R.S., Giaccia A., Blader I.J. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol 2006, 8:339-352.
30. Moser B., Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2:123-128.
31. Takatsu K., Kouro T., Nagai Y. Interleukin 5 in the link between the innate and acquired immune response. Adv Immunol 2009, 101:191-236. 10.1016/S0065-2776(08)01006-7.
32. Gómez Marín J.E., Montoya M.T., Castaño J.C., Alvarado F., Duque A.M., Chemla C., et al. Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in Colombian patients with acute and chronic ocular toxoplasmosis. Mem Inst Oswaldo Cruz 2000, 95:89-94.
33. Iyer J.V., Connolly J., Agrawal R., Yeo T.K., Lee B., Au B., et al. Cytokine analysis of aqueous humor in HIV patients with cytomegalovirus retinitis. Cytokine 2013, 64:541-547. 10.1016/j.cyto.2013.08.006.
34. Takase H., Futagami Y., Yoshida T., Mochizuki M., Kamoi K., Sugita S., et al. Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis. Invest Ophthalmol Vis Sci 2006, 47:1557-1561.
35. van Kooij B., Rothova A., Rijkers G.T., deGroot Mijnes J. Distinct cytokine and chemokine profiles in the aqueous humor of patients with uveitis and cystoid macular edema. Am J Ophthalmol 2006, 142:192-194.
36. Yoshimura T., Sonoda K.H., Ohguro N., et al. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology 2009, 48:347-355.
37. El-Asrar A.M.A., Struyfb S., Kangavea D., Al-Obeidana S.S., Opdenakkerb G., Geboesch K., et al. Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis. Clin Immunol 2011, 139:177-184.
38. Perez V.L., Papaliodis G.N., Chu D., Anzaar F., Christen W., Foster C.S. Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. Ocul Immunol Inflamm 2004, 12:193-201.
39. Saeij J.P., Coller S., Boyle J.P., Jerome M.E., White M.W., Boothroyd J.C. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007, 445:324-327.
40. O'Garra A., Vieira P.L., Vieira P., Goldfeld A.E. IL-10-producing and naturally-occurring CD4+ Tregs: limiting collateral damage. J Clin Invest 2004, 114:1372-1378.
41. Damsker J.M., Hansen A.M., Caspi R.R. Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci 2010, 1183:211-221.