Insulin preconditioning elevates p-akt and cardiac contractility after reperfusion in the isolated ischemic rat heart

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Sato, Tamaki ^a,b   Sato, Hiroaki ^a,b   Oguchi, Takeshi ^c   Fukushima, Hisashi ^c   Carvalho, George ^a   Lattermann, Ralph ^a   Matsukawa, Takashi ^b,c   Schricker, Thomas ^a,b  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b OUTCOMES RESEARCH CONSORTIUM   (United States)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TUMOR NECROSIS FACTOR ALPHA; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; INOTROPISM; INSULIN INFUSION; ISCHEMIC PRECONDITIONING; ISOLATED HEART; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; HEART CONTRACTION; HEART INFARCTION PREVENTION; HEART RATE; IN VITRO STUDY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; REPERFUSION INJURY; TIME; WISTAR RAT;

RATTUS;

ANIMALS; CORONARY CIRCULATION; HEART RATE; IN VITRO TECHNIQUES; INSULIN; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907412176     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/536510     Document Type: Article

References (29)

1. C. E. Murry, R. B. Jennings, and K. A. Reimer, "Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium," Circulation, vol. 74, no. 5, pp. 1124-1136, 1986.
2. R. F. Davis, L. W. V. DeBoer, R. E. Rude, E. Lowenstein, and P. R. Maroko, "The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion," Anesthesiology, vol. 59, no. 5, pp. 402-411, 1983.
3. D. C. Warltier, M. H. Al-Wathiqui, J. P. Kampine, and W. T. Schmeling, "Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane," Anesthesiology, vol. 69, no. 4, pp. 552-565, 1988.
4. J. Marijic, D. F. Stowe, L. A. Turner, J. P. Kampine, and Z. J. Bosnjak, "Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart," Anesthesiology, vol. 73,no. 5, pp. 976-983, 1990.
5. M. W. Bienengraeber, D. Weihrauch, J. R. Kersten, P. S. Pagel, and D. C. Warltier, "Cardioprotection by volatile anesthetics," Vascular Pharmacology, vol. 42, no. 5-6, pp. 243-252, 2005.
6. H. Sato, R. Hatzakorzian, G. Carvalho et al., "High-dose insulin administration improves left ventricular function after coronary artery bypass graft surgery," Journal of Cardiothoracic and Vascular Anesthesia, vol. 25, no. 6, pp. 1086-1091, 2011.
7. G. Carvalho, P. Pelletier, T. Albacker et al., "Cardioprotective effects of glucose and insulin administration while maintaining normoglycemia (GIN therapy) in patients undergoing coronary artery bypass grafting," The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 5, pp. 1469-1477, 2011.
8. A. K. Jonassen, E. Aasum, R. A. Riemersma, O. D. Mjøs, and T. S. Larsen, "Glucose-insulin-potassium reduces infarct size when administered during reperfusion," Cardiovascular Drugs and Therapy, vol. 14, no. 6, pp. 615-623, 2000.
9. A. K. Jonassen, O. D. Mjøs, and M. N. Sack, "p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling," Biochemical and Biophysical Research Communications, vol. 315, no. 1, pp. 160-165, 2004.
10. A. K. Jonassen, M. N. Sack, O. D. Mjøs, and D. M. Yellon, "Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cellsurvival signaling," Circulation Research, vol. 89,no. 12,pp. 1191-1198, 2001.
11. H. F. Zhang,Q. Fan, X. X. Qian et al., "Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion," Apoptosis, vol. 9, no. 6, pp. 777-783, 2004.
12. M. Ofir, M. Arad, E. Porat et al., "Increased glycogen stores due to γ-AMPK overexpression protects against ischemia and reperfusion damage," Biochemical Pharmacology, vol. 75, no. 7, pp. 1482-1491, 2008.
13. F. Iliadis, N. Kadoglou, and T. Didangelos, "Insulin and the heart," Diabetes Research and Clinical Practice, vol. 93, no. 1, pp. S86-S91, 2011.
14. L. Bertrand, S. Horman, C. Beauloye, and J. Vanoverschelde, "Insulin signalling in the heart," Cardiovascular Research, vol. 79, no. 2, pp. 238-248, 2008.
15. A. K. Jonassen, B. K. Brar, O. D. Mjøs, M. N. Sack, D. S. Latchman, and D. M. Yellon, "Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism," Journal of Molecular and Cellular Cardiology, vol. 32, no. 5, pp. 757-764, 2000.
16. Z. Q. Zhao, J. S. Corvera, M. E. Halkos et al., "Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning," American Journal of Physiology Heart and Circulatory Physiology, vol. 285, no. 2, pp. H579-H588, 2003.
17. T. Matsui, J. Tao, F. Del Monte et al., "Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo," Circulation, vol. 104, no. 3, pp. 330-335, 2001.
18. M. M. Mocanu, R. M. Bell, and D. M. Yellon, "PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning," Journal of Molecular and Cellular Cardiology, vol. 34, no. 6, pp. 661-668, 2002.
19. M. Alvarez-Tejado, S. Naranjo-Suárez, C. Jiménez, A. C. Carrera, M. O. Landázuri, and L. Del Peso, "Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. Protective role in apoptosis," The Journal of Biological Chemistry, vol. 276, no. 25, pp. 22368-22374, 2001.
20. B. N. Fuglesteg, C. Tiron, A. K. Jonassen, O. D. Mjøs, and K. Ytrehus, "Pretreatment with insulin before ischaemia reduces infarct size in Langendorff-perfused rat hearts," Acta Physiologica, vol. 195, no. 2, pp. 273-282, 2009.
21. A. Frank, M. Bonney, S. Bonney, L. Weitzel, M. Koeppen, and T. Eckle, "Myocardial ischemia reperfusion injury: from basic science to clinical bedside," Seminars in Cardiothoracic and Vascular Anesthesia, vol. 16, no. 3, pp. 123-132, 2012.
22. B. S. Cain, D. R. Meldrum, C. A. Dinarello et al., "Tumor necrosis factor-α and interleukin-1β synergistically depress human myocardial function," Critical Care Medicine, vol. 27, no. 7, pp. 1309-1318, 1999.
23. P. Kleinbongard, R. Schulz, and G. Heusch, "TNFα in myocardial ischemia/reperfusion, remodeling and heart failure," Heart Failure Reviews, vol. 16, no. 1, pp. 49-69, 2011.
24. X. Li, W. Cao, T. Li et al., "Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway," International Immunopharmacology, vol. 9, no. 9, pp. 1032-1041, 2009.
25. C. S. Apstein and L. H. Opie, "A challenge to the metabolic approach to myocardial ischaemia," European Heart Journal, vol. 26, no. 10, pp. 956-959, 2005.
26. D. J. Hausenloy and D. M. Yellon, "Preconditioning and postconditioning: united at reperfusion," Pharmacology and Therapeutics, vol. 116, no. 2, pp. 173-191, 2007.
27. J. Imagawa, G. F. Baxter, and D. M. Yellon, "Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo," Journal of Cardiovascular Pharmacology, vol. 31, no. 1, pp. 74-79, 1998.
28. H. Oral, G. W. Dorn II, and D. L. Mann, "Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte," The Journal of Biological Chemistry, vol. 272, no. 8, pp. 4836-4842, 1997.
29. B. S. Cain, A. H. Harken, and D. R. Meldrum, "Therapeutic strategies to reduce TNF-α mediated cardiac contractile depression following ischemia and reperfusion," Journal of Molecular and Cellular Cardiology, vol. 31, no. 5, pp. 931-947, 1999.