Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

Journal of Neuroinflammation

Volumn 11, Issue 1, 2014, Pages

  Impellizzeri, Daniela ^a   Bruschetta, Giuseppe ^a   Cordaro, Marika ^a   Crupi, Rosalia ^a   Siracusa, Rosalba ^a   Esposito, Emanuela ^a   Cuzzocrea, Salvatore ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Edema; Hyperalgesia; Inflammation; Micronized; Oral administration; Pain; Palmitoylethanolamide; Ultramicronized

Indexed keywords

CARRAGEENAN; MYELOPEROXIDASE; PALMIDROL; ANALGESIC AGENT; ETHANOLAMINE DERIVATIVE; PALMITIC ACID DERIVATIVE; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG PURITY; ENZYME ACTIVITY; HYPERALGESIA; IN VIVO STUDY; INFLAMMATORY INFILTRATE; INFLAMMATORY PAIN; MALE; NONHUMAN; PARTICLE SIZE; PAW EDEMA; PHYSICAL CHEMISTRY; RAT; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; EDEMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATION; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PAIN; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CARRAGEENAN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; EDEMA; ETHANOLAMINES; HYPERALGESIA; INFLAMMATION; MALE; MICROSCOPY, ELECTRON, SCANNING; PAIN; PALMITIC ACIDS; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84907412062     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0136-0     Document Type: Article

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