A control strategy for bioavailability enhancement by size reduction: Effect of micronization conditions on the bulk, surface and blending characteristics of an active pharmaceutical ingredient

Powder Technology

Volumn 258, Issue , 2014, Pages 222-233

  Olusanmi, Dolapo ^a   Jayawickrama, Dimuthu ^a   Bu, Dongsheng ^a   McGeorge, Gary ^a   Sailes, Helen ^a   Kelleher, Joanne ^a   Gamble, John F ^a   Shah, Umang V ^b   Tobyn, Mike ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Blending; Cohesion; Micronization; Milling; QbD; Surface area; Surface energy

Indexed keywords

BIOCHEMISTRY; BLENDING; DRUG DELIVERY; DRUG PRODUCTS; INTERFACIAL ENERGY; MILLING (MACHINING); PARTICLE SIZE ANALYSIS; SIZE DETERMINATION;

ACTIVE PHARMACEUTICAL INGREDIENTS; BIOAVAILABILITY ENHANCEMENTS; COHESION; MANUFACTURING PARAMETERS; MATERIAL CHARACTERISTICS; MICRONIZATIONS; QBD; SURFACE AREA;

SURFACES;

ARTICLE; CHEMICAL PROCEDURES; ENZYME POLYMORPHISM; FLOW MEASUREMENT; IMAGE ANALYSIS; LIGHT SCATTERING; MATHEMATICAL PHENOMENA; MICRONIZATION; MORPHOLOGY; PARTICLE SIZE; PHARMACEUTICS; PRACTICE GUIDELINE; PROCESS CONTROL; PROCESS DESIGN; REPRODUCIBILITY; SHEAR STRESS; THERMODYNAMICS; TREADMILL; X RAY DIFFRACTION;

EID: 84896933359     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2014.03.032     Document Type: Article

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