Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it

Journal of Diabetes Research

Volumn 2014, Issue , 2014, Pages

  Li, Xin ^a   Jiang, Li ^a   Yang, Miao ^a   Wu, Yu Wen ^a   Sun, Su Xin ^a   Sun, Jia Zhong ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; COMPLEMENT COMPONENT C1Q TUMOR NECROSIS FACTOR RELATED PROTEIN 3; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; MESSENGER RNA; STREPTOZOCIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 3, RAT; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; PEPTIDE; VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS FAT; GENE EXPRESSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID DIET; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; AGONISTS; ANIMAL; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE COURSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TIME; WISTAR RAT;

ADIPOKINES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MALE; PEPTIDES; RATS, WISTAR; RECEPTORS, GLUCAGON; RNA, MESSENGER; STREPTOZOCIN; TIME FACTORS; VENOMS;

EID: 84907405834     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2014/398518     Document Type: Article

References (28)

1. S. H. Ley, O. Hamdy, V. Mohan et al., "Prevention and management of 2 diabetes: dietary components and nutritional strategies," The Lancet, vol. 383, no. 9933, pp. 1999-2007, 2014.
2. J. Yang, J. Kang, and Y. Guan, "The mechanisms linking adiposopathy to type 2 diabetes," Frontiere Medicale, vol. 7, no. 4, pp. 433-444, 2013.
3. A. Giordano, A. Smorlesi, A. Frontini, G. Barbatelli, and S. Cinti, "White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ," European Journal of Endocrinology, vol. 170, no. 5, pp. R159-R171, 2014.
4. M. K. Piya, P. G. McTernan, and S. Kumar, "Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin," Journal of Endocrinology, vol. 216, no. 1, pp. T1-T15, 2013.
5. J. M. Peterson, Z. Wei, and G. W. Wong, "C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output," Journal of Biological Chemistry, vol. 285, no. 51, pp. 39691-39701, 2010.
6. J. M. Peterson, M. M. Seldin, Z. Wei, S. Aja, and G. W. Wong, "CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism," American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 305, no. 3, pp. G214-G224, 2013.
7. A. Schmid, A. Kopp, F. Hanses, M. Bala, M. Müller, and A. Schäffler, "The novel adipokine C1q/TNF-related protein-3 is expressed in human adipocytes and regulated by metabolic and infection-related parameters," Experimental and Clinical Endocrinology and Diabetes, vol. 120, no. 10, pp. 611-617, 2012.
8. K. M. Choi, S. Y. Hwang, H. C. Hong et al., "C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome," Diabetes, vol. 61, no. 11, pp. 2932-2936, 2012.
9. B. K. Tan, J. Chen, J. Hu et al., "Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome," The Journal of Clinical Endocrinology & Metabolism, vol. 98, no. 12, pp. E1891-E1900, 2013.
10. H. Y. Choi, J. W. Park, N. Lee et al., "Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels," Diabetes Care, vol. 36, no. 10, pp. 3321-3327, 2013.
11. M. Y. Donath and R. Burcelin, "GLP-1 effects on islets: hormonal, neuronal, or paracrine?" Diabetes Care, vol. 36, supplement 2, pp. S145-S148, 2013.
12. L. T. K. Chung, T. Hosaka, M. Yoshida et al., "Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression," Biochemical and Biophysical Research Communications, vol. 390, no. 3, pp. 613-618, 2009.
13. X. Li, L. Yuan, J. Li, H. Li, and S. Cheng, "Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet," Experimental Diabetes Research, vol. 2012, Article ID 618923, 7 pages, 2012.
14. M. S. Islam and D. T. Loots, "Experimental rodent models of type 2 diabetes: a review," Methods and Findings in Experimental and Clinical Pharmacology, vol. 31, no. 4, pp. 249-261, 2009.
15. Y. Wang, T. Campbell, B. Perry, C. Beaurepaire, and L. Qin, "Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats," Metabolism, vol. 60, no. 2, pp. 298-305, 2011.
16. M. Zhang, X. Lv, J. Li, Z. Xu, and L. Chen, "The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model," Experimental Diabetes Research, vol. 2008, Article ID704045, 9 pages, 2008.
17. X. Li, L. Yuan, G. Xu et al., "Effect of renin angiotensin system blockade on the islet microvessel density of diabetic rats and its relationship with islet function," Journal of Huazhong University of Science and Technology - Medical Science, vol. 29, no. 6, pp. 684-688, 2009.
18. H. Wang, H. Li, and X. Jiang, "Hepcidin is directly regulated by insulin and plays an important role in iron overload in strep-tozotocin- induced diabetic rats," Diabetes, vol. 63, no. 5, pp. 1506-1518, 2014.
19. J. Su, L. Zhou, X. Kong et al., "Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus," Journal of Diabetes Research, vol. 2013, Article ID 193461, 6 pages, 2013.
20. L. Yuan, X. Li, G. L. Xui, and C. Qi, "Effects of renin-angiotensin system blockade on islet function in diabetic rats," Journal of Endocrinological Investigation, vol. 33, no. 1, pp. 13-19, 2010.
21. L. Yuan, X. Li, J. Li, H. Li, and S. Cheng, "Effects of renin-angiotensin system blockade on the islet morphology and function in rats with long-termhigh-fat diet," Acta Diabetologica, vol. 50, no. 4, pp. 479-488, 2013.
22. J. J. Meier, "GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus," Nature Reviews Endocrinology, vol. 8, no. 12, pp. 728-742, 2012.
23. C. Hölscher, "Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases," Journal of Endocrinology, vol. 221, no. 1, pp. T31-T41, 2014.
24. J. Vendrell, R. El Bekay, B. Peral et al., "Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance," Endocrinology, vol. 152, no. 11, pp. 4072-4079, 2011.
25. T. D. Challa, N. Beaton, M. Arnold, G. Rudofsky, W. Langhans, and C. Wolfrum, "Regulation of adipocyte formation by GLP-1/GLP-1R signaling," The Journal of Biological Chemistry, vol. 287, no. 9, pp. 6421-6430, 2012.
26. Y.-S. Lee, M.-S. Park, J.-S. Choung et al., "Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes," Diabetologia, vol. 55, no. 9, pp. 2456-2468, 2012.
27. R. Liu, X. Ding, Y. Wang, M. Wang, and Y. Peng, "Glucagon-like peptide-1 upregulates visfatin expression in 3T3-L1 adipocytes," Hormone and Metabolic Research, vol. 45, no. 9, pp. 646-651, 2013.
28. A. Kopp, M. Bala, C. Buechler et al., "C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue," Endocrinology, vol. 151, no. 11, pp. 5267-5278, 2010.