RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association

Cell Reports

Volumn 8, Issue 6, 2014, Pages 1894-1904

  Goodman, Kerry M ^a   Kjær, Svend ^a   Beuron, Fabienne ^b   Knowles, Phillip P ^a   Nawrotek, Agata ^a   Burns, Emily M ^a   Purkiss, Andrew G ^a   George, Roger ^a   Santoro, Massimo ^c   Morris, Edward P ^b   McDonald, Neil Q ^a,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; EPITOPE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LIGAND; MEMBRANE PROTEIN; PROTEIN RET; TYROSINE KINASE RECEPTOR; ANTIBODY; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; PROTEIN BINDING; RECOMBINANT PROTEIN; ZEBRAFISH PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CHO CELL LINE; CONTROLLED STUDY; DEREGULATION; ELECTRON MICROSCOPY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; RADIATION SCATTERING; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CHEMISTRY; CRICETULUS; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; BINDING SITES; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; EPITOPES; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84907382852     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.08.040     Document Type: Article

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