Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction

Journal of Proteomics

Volumn 109, Issue , 2014, Pages 368-381

  Alonso Orgaz, Sergio ^a   Moreno Luna, Rafael ^a   López, Juan A ^b   Gil Dones, Felix ^a   Padial, Luis R ^c   Moreu, Jose ^c   De la Cuesta, Fernando ^a   Barderas, Maria G ^a  

^a HOSPITAL NACIONAL DE PARAPLÉJICOS   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c HOSPITAL VIRGEN DE LA SALUD   (Spain)

Author keywords

Acute myocardial infarction; DIDO1; Focal adhesion; Human coronary artery; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; BETA PARVIN; CALRETICULIN; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CATALASE; CD14 ANTIGEN; CLOPIDOGREL; EOSINOPHIL PEROXIDASE; FERMITIN HOMOLOG 3; FIBRIN; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; LEUKOCYTE ELASTASE; LOW MOLECULAR WEIGHT HEPARIN; MULTIMERIN 1; MYOSIN 9; PROTEOME; RAP1B PROTEIN; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; ABCIXIMAB; CELL MARKER; DIDO1 PROTEIN; FERMITIN FAMILY HOMOLOG 3; PROTEIN; RAP1 PROTEIN; RAS RELATED PROTEIN RAP1B; THROMBIN; BIOLOGICAL MARKER;

ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CORONARY ARTERY THROMBOSIS; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MALE; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; T LYMPHOCYTE; TANDEM MASS SPECTROMETRY; THROMBECTOMY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ACUTE HEART INFARCTION; ADULT; ANTIBODY AFFINITY; CARDIAC PATIENT; CARDIOVASCULAR RISK; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FIBRINOLYTIC THERAPY; FOCAL ADHESION; HISTOPATHOLOGY; ISOELECTRIC FOCUSING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; ST SEGMENT ELEVATION; THORAX PAIN; THROMBOCYTE; THROMBOCYTE ACTIVATION; UPREGULATION; AGED; CLINICAL TRIAL; CORONARY THROMBOSIS; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; MYOCARDIAL INFARCTION; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CORONARY THROMBOSIS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROTEOME; PROTEOMICS;

EID: 84907374480     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.07.016     Document Type: Article

References (45)

1. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001, 114:365-372.
2. Libby P., Ganz P., Schoen F.J., Lee R.T. The vascular biology of the acute coronary syndromes. Acute coronary syndromes 2000, 33-57. Marcel Dekker, Inc., New York. E.J. Topol (Ed.).
3. Barderas M.G., Tuñón J., Dardé V.M., De la Cuesta F., Durán M.C., Jiménez-Nácher J.J., et al. Circulating human monocytes in the acute coronary syndrome express a characteristic proteomic profile. J Proteome Res 2007, 6:876-886.
4. Huo Y., Schober A., Forlow S.B., Smith D.F., Hyman M.C., Jung S., et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 2003, 9:61-67.
5. Furman M.I., Barnard M.R., Krueger L.A., Fox M.L., Shilale E.A., Lessard D.M., et al. Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 2001, 38:1002-1006.
6. Parguiña A.F., Grigorian-Shamajian L., Agra R.M., Teijeira-Fernández E., Rosa I., Alonso J., et al. Proteins involved in platelet signaling are differentially regulated in acute coronary syndrome: a proteomic study. PLoS One 2010, 5:e13404.
7. Huang H., Vogel H.J. Structural basis for the activation of platelet integrin αIIbβ3 by calcium- and integrin-binding protein 1. J Am Chem Soc 2012, 134:3864-3872.
8. Wolberg A.S. Plasma and cellular contributions to fibrin network formation, structure and stability. Haemophilia 2010, 16(Suppl. 3):7-12.
9. Kaplan Z.S., Jackson S.P. The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program 2011, 2011:51-61.
10. Stolla M., Stefanini L., Roden R.C., Chavez M., Hirsch J., Greene T., et al. The kinetics ofαIIbβ3 activation determines the size and stability of thrombi in mice: Implications for antiplatelet therapy. Blood 2011, 117:1005-1013.
11. Svilaas T., van der Horst I.C., Zijlstra F. Thrombus aspiration during percutaneous coronary intervention in acute myocardial infarction Study (TAPAS)-Study design. Am Heart J 2006, 151:597.e1-597.e7.
12. Li X., Kramer M.C., VAN DER Loos C.M., Ploegmakers H.J., DE Boer O.J., Koch K.T., et al. Early onset of endothelial cell proliferation in coronary thrombi of patients with an acute myocardial infarction: implications for plaque healing. J Thromb Haemost 2012, 10:466-473.
13. Kramer M.C., van der Wal A.C., Koch K.T., Ploegmakers J.P., van der Schaaf R.J., Henriques J.P., et al. Presence of older thrombus is an independent predictor of long-term mortality in patients with ST-elevation myocardial infarction treated with thrombus aspiration during primary percutaneous coronary intervention. Circulation 2008, 118:1810-1816.
14. Yamashita A., Sumi T., Goto S., Hoshiba Y., Nishihira K., Kawamoto R., et al. Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction. Am J Cardiol 2006, 97:26-28.
15. Silvain J., Collet J.P., Nagaswami C., Beygui F., Edmondson K.E., Bellemain-Appaix A., et al. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol 2011, 57:1359-1367.
16. Cubedo J., Ramaiola I., Padró T., Martin-Yuste V., Sabate-Tenas M., Badimon L. High-molecular-weight kininogen and the intrinsic coagulation pathway in patients with de novo acute myocardial infarction. Thromb Haemost 2013, 110:1121-1134.
17. García A., Prabhakar S., Brock C.J., Pearce A.C., Dwek R.A., Watson S.P., et al. Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 2004, 4:656-668.
18. Kakhniashvili D.G., Bulla L.A., Goodman S.R. The human erythrocyte proteome: analysis by ion trap mass spectrometry. Mol Cell Proteomics 2004, 3:501-509.
19. Jin M., Diaz P.T., Bourgeois T., Eng C., Marsh C.B., Wu H.M. Two-dimensional gel proteome reference map of blood monocytes. Proteome Sci 2006, 4:16.
20. de la Cuesta F., Alvarez-Llamas G., Maroto A.S., Donado A., Zubiri I., Posada M., et al. Vivanco F A proteomic focus on the alterations occurring at the human atherosclerotic coronary intima. Mol Cell Proteomics 2011, 10. [M110.003517].
21. Lepedda A.J., Cigliano A., Cherchi G.M., Spirito R., Maggioni M., Carta F., et al. A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries. Atherosclerosis 2009, 203:112-118.
22. de la Cuesta F., Zubiri I., Maroto A.S., Posada M., Padial L.R., Vivanco F., et al. Deregulation of smooth muscle cell cytoskeleton within the human atherosclerotic coronary media layer. J Proteomics 2013, 82:155-165.
23. Bagnato C., Thumar J., Mayya V., Hwang S.I., Zebroski H., Claffey K.P., et al. Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics 2007, 6:1088-1102.
24. Guo W., Xue J., Shi J., Li N., Shao Y., Yu X., et al. Proteomics analysis of distinct portal vein tumor thrombi in hepatocellular carcinoma patients. J Proteome Res 2010, 9:4170-4175.
25. Moxon J.V., Padula M.P., Clancy P., Emeto T.I., Herbert B.R., Norman P.E., et al. Proteomic analysis of intra-arterial thrombus secretions reveals a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm. Atherosclerosis 2011, 219:432-439.
26. Martinez-Pinna R., Madrigal-Matute J., Tarin C., Burillo E., Esteban-Salan M., Pastor-Vargas C., et al. Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2013, 33:2013-2020.
27. de la Cuesta F., Barderas M.G., Calvo E., Zubiri I., Maroto A.S., Darde V.M., et al. Secretome analysis of atherosclerotic and non-atherosclerotic arteries reveals dynamic extracellular remodeling during pathogenesis. J Proteomics 2012, 75:2960-2971.
28. Martín-Rojas T., Gil-Dones F., Lopez-Almodovar L.F., Padial L.R., Vivanco F., Barderas M.G. Proteomic profile of human aortic stenosis: insights into the degenerative process. J Proteome Res 2012, 11:1537-1550.
29. Shevchenko A., Tomas H., Havlis J., Olsen J.V., Mann M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc 2006, 1:2856-2860.
30. Huang D.W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009, 37:1-13.
31. Krishna S.M., Golledge J. The role of thrombospondin-1 in cardiovascular health and pathology. Int J Cardiol 2013, 168:692-706.
32. Lawler J., Hynes R.O. An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood 1989, 1(74):2022-2027.
33. Moser M., Nieswandt B., Ussar S., Pozgajova M., Fässler R. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 2008, 14:325-330.
34. Wang L., Deng W., Shi T., Ma D. URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis. Biochem Biophys Res Commun 2008, 368:899-906.
35. Randriamboavonjy V., Isaak J., Elgheznawy A., Pistrosch F., Frömel T., Yin X., et al. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood 2012, 120:415-423.
36. Zhang Y., Chen K., Tu Y., Wu C. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. J Biol Chem 2004, 279:695-705.
37. Kimura M., Murakami T., Kizaka-Kondoh S., Itoh M., Yamamoto K., Hojo Y., et al. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. J Cell Sci 2010, 123:747-755.
38. Betapudi V. Myosin II, motor proteins with different functions determine the fate of lamellipodia extension during cell spreading. PLoS One 2010, 5:e8560.
39. Léon C., Eckly A., Hechler B., Aleil B., Freund M., Ravanat C., et al. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood 2007, 110:3183-3191.
40. Guidetti G.F., Torti M. The small GTPase Rap1b: a bidirectional regulator of platelet adhesion receptors. J Signal Transduct 2012, 2012:412089.
41. Chrzanowska-Wodnicka M., Smyth S.S., Schoenwaelder S.M., Fischer T.H., White G.C. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Investig 2005, 115:680-687.
42. Jeimy S.B., Tasneem S., Cramer E.M., Hayward C.P. Multimerin 1. Platelets 2008, 19:83-95.
43. Reheman A., Tasneem S., Ni H., Hayward C.P. Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1. Thromb Res 2010, 125:e177-e183.
44. Adam F., Zheng S., Joshi N., Kelton D.S., Sandhu A., Suehiro Y., et al. Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3. Thromb Haemost 2005, 945:1004-1011.
45. Fütterer A., Campanero M.R., Leonardo E., Criado L.M., Flores J.M., Hernández J.M., et al. Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. J Clin Invest 2005, 115:2351-2362.