Multistage-targeted pH-responsive polymer conjugate of Auger electron emitter: Optimized design and in vivo activity

European Journal of Pharmaceutical Sciences

Volumn 63, Issue , 2014, Pages 216-225

  Sedlacek, Ondrej ^a   Kucka, Jan ^a   Mattova, Jana ^b   Parizek, Martin ^c   Studenovsky, Martin ^a   Zadinova, Marie ^b   Pouckova, Pavla ^b   Hruby, Martin ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Auger electrons; Drug delivery; Ellipticine; Intercalator; Iodine 125; Radiotherapy

Indexed keywords

ELLIPTICINE; INTERCALATING AGENT; IODINE 125; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; POLYMER; ANTINEOPLASTIC AGENT; ELLIPTICINE DERIVATIVE; RADIOACTIVE IODINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUGER ELECTRON SPECTROSCOPY; BIOCOMPATIBILITY; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG POTENCY; ENDOSOME; IN VIVO STUDY; INCUBATION TIME; INTERNALIZATION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RADIOACTIVITY; SURVIVAL RATE; TUMOR CELL; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; ELECTRON; FEMALE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTRONS; ELLIPTICINES; FEMALE; HYDROGEN-ION CONCENTRATION; IODINE RADIOISOTOPES; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; POLYMERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907370696     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.07.012     Document Type: Article

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