Self-assembling peptide-based nanoparticles enhance cellular delivery of the hydrophobic anticancer drug ellipticine through caveolae-dependent endocytosis

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 5, 2012, Pages 647-654

  Bawa, Roli ^a,b   Fung, Shan Yu ^a   Shiozaki, Atsushi ^a   Yang, Hong ^a   Zheng, Gang ^c   Keshavjee, Shaf ^a,b   Liu, Mingyao ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Drug delivery; Endocytosis; Intracellular distribution; Nanotechnology

Indexed keywords

A549 CELLS; ANTI-CANCER AGENTS; ANTICANCER ACTIVITIES; ANTICANCER DRUG; AVERAGE SIZE; CELLULAR DELIVERY; CLINICAL APPLICATION; DELIVERY PATHWAYS; ELLIPTICINE; ENDOCYTOSIS; ENHANCED UPTAKE; HUMAN LUNG; INTRACELLULAR DISTRIBUTION; PROTONATED; SELF-ASSEMBLING; SELF-ASSEMBLING PEPTIDES; SPECIAL CLASS; THERAPEUTIC EFFICACY;

CYTOLOGY; DIMETHYL SULFOXIDE; DRUG DELIVERY; HYDROPHOBICITY; MOLECULAR BIOLOGY; NANOPARTICLES; NANOTECHNOLOGY; PROTONATION; SOLUTIONS;

PEPTIDES;

DIMETHYL SULFOXIDE; ELLIPTICINE; NANOPARTICLE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CAVEOLA; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG STRUCTURE; ENDOCYTOSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; LUNG CARCINOMA;

ANTINEOPLASTIC AGENTS; CAVEOLAE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; ELLIPTICINES; ENDOCYTOSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOPARTICLES; OLIGOPEPTIDES; PARTICLE SIZE;

EID: 84862669640     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.08.007     Document Type: Article

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