Development of a UPLC-MS/MS bioanalytical method for the pharmacokinetic study of (-)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 967, Issue , 2014, Pages 162-167

  Wong, Ka Chun ^a   Law, Man Chun ^a   Wong, Man Sau ^a,b   Chan, Tak Hang ^a,c  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation)   (China)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

( ) Epiafzelechin; Intraperitoneal; Intravenous; Pharmacokinetics; UPLC MS MS

Indexed keywords

BLOOD; FLAVONOIDS; FORMIC ACID; PHARMACOKINETICS; LIQUIDS; MAMMALS;

(-)-EPIAFZELECHIN; INTRAPERITONEAL; INTRAVENOUS; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTITATIONS; MAXIMUM CONCENTRATIONS; PHARMACOKINETIC STUDIES; UPLC-MS/MS; PLASMA DRUG CONCENTRATION;

MAMMALS; EXTRACTION;

ACETIC ACID ETHYL ESTER; AFZELECHIN; CATECHIN; FLAVAN DERIVATIVE; PROTECTIVE AGENT; UNCLASSIFIED DRUG; WATER; EPIAFZELECHIN; FORMIC ACID; ACETONITRILE; ACETONITRILE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BONE CHARACTERISTICS AND FUNCTIONS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; ELECTROSPRAY; ELUTION; FEMALE; FLOW RATE; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OSTEOPROTECTIVE ACTIVITY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTECTION; ROOM TEMPERATURE; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; C57BL 6 MOUSE; DISTRIBUTION HALF-LIFE; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; PROCEDURES; REPRODUCIBILITY;

MUS;

ACETONITRILES; ANIMALS; CATECHIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FEMALE; LIMIT OF DETECTION; MICE; MICE, INBRED C57BL; PROTECTIVE AGENTS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84907363580     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.07.028     Document Type: Article

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