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Volumn 41, Issue 2, 2014, Pages 207-218

αβT cell receptors expressed by CD4-CD8αβ- intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ALPHA BETA ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHABETA; UNCLASSIFIED DRUG;

EID: 84907357351     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.07.010     Document Type: Article
Times cited : (60)

References (57)
  • 1
    • 84866092059 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in celiac disease immunopathology
    • Abadie V., Discepolo V., Jabri B. Intraepithelial lymphocytes in celiac disease immunopathology. Semin. Immunopathol. 2012, 34:551-566.
    • (2012) Semin. Immunopathol. , vol.34 , pp. 551-566
    • Abadie, V.1    Discepolo, V.2    Jabri, B.3
  • 2
    • 47949106921 scopus 로고    scopus 로고
    • Retrogenic modeling of experimental allergic encephalomyelitis associates Tcell frequency but not TCR functional affinity with pathogenicity
    • Alli R., Nguyen P., Geiger T.L. Retrogenic modeling of experimental allergic encephalomyelitis associates Tcell frequency but not TCR functional affinity with pathogenicity. J.Immunol. 2008, 181:136-145.
    • (2008) J.Immunol. , vol.181 , pp. 136-145
    • Alli, R.1    Nguyen, P.2    Geiger, T.L.3
  • 4
    • 4344622052 scopus 로고    scopus 로고
    • Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer
    • Arnold P.Y., Burton A.R., Vignali D.A. Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer. J.Immunol. 2004, 173:3103-3111.
    • (2004) J.Immunol. , vol.173 , pp. 3103-3111
    • Arnold, P.Y.1    Burton, A.R.2    Vignali, D.A.3
  • 5
    • 84861733007 scopus 로고    scopus 로고
    • T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice
    • Bettini M.L., Bettini M., Vignali D.A. T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology 2012, 136:265-272.
    • (2012) Immunology , vol.136 , pp. 265-272
    • Bettini, M.L.1    Bettini, M.2    Vignali, D.A.3
  • 6
    • 84872943896 scopus 로고    scopus 로고
    • Invariant natural killer Tcells: an innate activation scheme linked to diverse effector functions
    • Brennan P.J., Brigl M., Brenner M.B. Invariant natural killer Tcells: an innate activation scheme linked to diverse effector functions. Nat. Rev. Immunol. 2013, 13:101-117.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 101-117
    • Brennan, P.J.1    Brigl, M.2    Brenner, M.B.3
  • 7
    • 38949162969 scopus 로고    scopus 로고
    • Doubting the TCR coreceptor function of CD8alphaalpha
    • Cheroutre H., Lambolez F. Doubting the TCR coreceptor function of CD8alphaalpha. Immunity 2008, 28:149-159.
    • (2008) Immunity , vol.28 , pp. 149-159
    • Cheroutre, H.1    Lambolez, F.2
  • 8
    • 79959664629 scopus 로고    scopus 로고
    • The light and dark sides of intestinal intraepithelial lymphocytes
    • Cheroutre H., Lambolez F., Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 2011, 11:445-456.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 9
    • 79960362531 scopus 로고    scopus 로고
    • CD3+CD4-CD8- (double negative) Tcells: saviours or villains of the immune response?
    • D'Acquisto F., Crompton T. CD3+CD4-CD8- (double negative) Tcells: saviours or villains of the immune response?. Biochem. Pharmacol. 2011, 82:333-340.
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 333-340
    • D'Acquisto, F.1    Crompton, T.2
  • 11
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • Davis M.M., Bjorkman P.J. T-cell antigen receptor genes and T-cell recognition. Nature 1988, 334:395-402.
    • (1988) Nature , vol.334 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 13
    • 84859158571 scopus 로고    scopus 로고
    • Making memory at birth: understanding the differentiation of natural killer Tcells
    • Engel I., Kronenberg M. Making memory at birth: understanding the differentiation of natural killer Tcells. Curr. Opin. Immunol. 2012, 24:184-190.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 184-190
    • Engel, I.1    Kronenberg, M.2
  • 14
    • 77956310634 scopus 로고    scopus 로고
    • Efficient isolation of mouse liver NKT cells by perfusion
    • Fang X., Du P., Liu Y., Tang J. Efficient isolation of mouse liver NKT cells by perfusion. PLoS ONE 2010, 5:e10288.
    • (2010) PLoS ONE , vol.5
    • Fang, X.1    Du, P.2    Liu, Y.3    Tang, J.4
  • 15
    • 0030584690 scopus 로고    scopus 로고
    • Development of CD8 alpha alpha+ intestinal intraepithelial Tcells in beta 2-microglobulin- and/or TAP1-deficient mice
    • Fujiura Y., Kawaguchi M., Kondo Y., Obana S., Yamamoto H., Nanno M., Ishikawa H. Development of CD8 alpha alpha+ intestinal intraepithelial Tcells in beta 2-microglobulin- and/or TAP1-deficient mice. J.Immunol. 1996, 156:2710-2715.
    • (1996) J.Immunol. , vol.156 , pp. 2710-2715
    • Fujiura, Y.1    Kawaguchi, M.2    Kondo, Y.3    Obana, S.4    Yamamoto, H.5    Nanno, M.6    Ishikawa, H.7
  • 16
    • 33749526537 scopus 로고    scopus 로고
    • Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus
    • Gangadharan D., Lambolez F., Attinger A., Wang-Zhu Y., Sullivan B.A., Cheroutre H. Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus. Immunity 2006, 25:631-641.
    • (2006) Immunity , vol.25 , pp. 631-641
    • Gangadharan, D.1    Lambolez, F.2    Attinger, A.3    Wang-Zhu, Y.4    Sullivan, B.A.5    Cheroutre, H.6
  • 17
    • 0032846123 scopus 로고    scopus 로고
    • Cutting edge: TCR alpha beta+ CD8 alpha alpha+ Tcells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules
    • Gapin L., Cheroutre H., Kronenberg M. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ Tcells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J.Immunol. 1999, 163:4100-4104.
    • (1999) J.Immunol. , vol.163 , pp. 4100-4104
    • Gapin, L.1    Cheroutre, H.2    Kronenberg, M.3
  • 18
    • 83655191565 scopus 로고    scopus 로고
    • Epithelial barrier: an interface for the cross-communication between gut flora and immune system
    • Goto Y., Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol. Rev. 2012, 245:147-163.
    • (2012) Immunol. Rev. , vol.245 , pp. 147-163
    • Goto, Y.1    Kiyono, H.2
  • 19
    • 0026034717 scopus 로고
    • Two gut intraepithelial CD8+ lymphocyte populations with different Tcell receptors: a role for the gut epithelium in Tcell differentiation
    • Guy-Grand D., Cerf-Bensussan N., Malissen B., Malassis-Seris M., Briottet C., Vassalli P. Two gut intraepithelial CD8+ lymphocyte populations with different Tcell receptors: a role for the gut epithelium in Tcell differentiation. J.Exp. Med. 1991, 173:471-481.
    • (1991) J.Exp. Med. , vol.173 , pp. 471-481
    • Guy-Grand, D.1    Cerf-Bensussan, N.2    Malissen, B.3    Malassis-Seris, M.4    Briottet, C.5    Vassalli, P.6
  • 20
    • 0029848909 scopus 로고    scopus 로고
    • Complexity of the mouse gut Tcell immune system: identification of two distinct natural killer Tcell intraepithelial lineages
    • Guy-Grand D., Cuénod-Jabri B., Malassis-Seris M., Selz F., Vassalli P. Complexity of the mouse gut Tcell immune system: identification of two distinct natural killer Tcell intraepithelial lineages. Eur. J. Immunol. 1996, 26:2248-2256.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2248-2256
    • Guy-Grand, D.1    Cuénod-Jabri, B.2    Malassis-Seris, M.3    Selz, F.4    Vassalli, P.5
  • 22
    • 84859392140 scopus 로고    scopus 로고
    • MHC class Ib-restricted CD8 Tcells differ in dependence on CD4 Tcell help and CD28 costimulation over the course of mouse polyomavirus infection
    • Hofstetter A.R., Ford M.L., Sullivan L.C., Wilson J.J., Hadley A., Brooks A.G., Lukacher A.E. MHC class Ib-restricted CD8 Tcells differ in dependence on CD4 Tcell help and CD28 costimulation over the course of mouse polyomavirus infection. J.Immunol. 2012, 188:3071-3079.
    • (2012) J.Immunol. , vol.188 , pp. 3071-3079
    • Hofstetter, A.R.1    Ford, M.L.2    Sullivan, L.C.3    Wilson, J.J.4    Hadley, A.5    Brooks, A.G.6    Lukacher, A.E.7
  • 23
    • 33646356743 scopus 로고    scopus 로고
    • Rapid analysis of T-cell selection invivo using Tcell-receptor retrogenic mice
    • Holst J., Vignali K.M., Burton A.R., Vignali D.A. Rapid analysis of T-cell selection invivo using Tcell-receptor retrogenic mice. Nat. Methods 2006, 3:191-197.
    • (2006) Nat. Methods , vol.3 , pp. 191-197
    • Holst, J.1    Vignali, K.M.2    Burton, A.R.3    Vignali, D.A.4
  • 24
    • 0025039030 scopus 로고
    • A new surface antigen on intraepithelial lymphocytes in the intestine
    • Kilshaw P.J., Murant S.J. A new surface antigen on intraepithelial lymphocytes in the intestine. Eur. J. Immunol. 1990, 20:2201-2207.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2201-2207
    • Kilshaw, P.J.1    Murant, S.J.2
  • 25
    • 33846783082 scopus 로고    scopus 로고
    • Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs
    • Lambolez F., Kronenberg M., Cheroutre H. Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs. Immunol. Rev. 2007, 215:178-188.
    • (2007) Immunol. Rev. , vol.215 , pp. 178-188
    • Lambolez, F.1    Kronenberg, M.2    Cheroutre, H.3
  • 27
    • 33845522671 scopus 로고    scopus 로고
    • Using bioinformatics tools for the sequence analysis of immunoglobulins and Tcell receptors
    • Lefranc M.P. Using bioinformatics tools for the sequence analysis of immunoglobulins and Tcell receptors. Curr. Protoc. Immunol. 2006, 1(Appendix):1W.
    • (2006) Curr. Protoc. Immunol. , vol.1 , Issue.APPENDIX
    • Lefranc, M.P.1
  • 28
    • 0025936929 scopus 로고
    • Phenotypic complexity of intraepithelial lymphocytes of the small intestine
    • Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J.Immunol. 1991, 147:1746-1751.
    • (1991) J.Immunol. , vol.147 , pp. 1746-1751
    • Lefrancois, L.1
  • 30
    • 0036199258 scopus 로고    scopus 로고
    • Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) Tcells are positively selected in the thymus by agonist self-peptides
    • Leishman A.J., Gapin L., Capone M., Palmer E., MacDonald H.R., Kronenberg M., Cheroutre H. Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) Tcells are positively selected in the thymus by agonist self-peptides. Immunity 2002, 16:355-364.
    • (2002) Immunity , vol.16 , pp. 355-364
    • Leishman, A.J.1    Gapin, L.2    Capone, M.3    Palmer, E.4    MacDonald, H.R.5    Kronenberg, M.6    Cheroutre, H.7
  • 32
    • 70449713909 scopus 로고    scopus 로고
    • Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes invivo
    • Medina F., Ramos M., Iborra S., de León P., Rodríguez-Castro M., Del Val M. Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes invivo. J.Immunol. 2009, 183:4639-4647.
    • (2009) J.Immunol. , vol.183 , pp. 4639-4647
    • Medina, F.1    Ramos, M.2    Iborra, S.3    de León, P.4    Rodríguez-Castro, M.5    Del Val, M.6
  • 33
    • 0021342654 scopus 로고
    • A nonpolymorphic class I gene in the murine major histocompatibility complex
    • Mellor A.L., Weiss E.H., Kress M., Jay G., Flavell R.A. A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell 1984, 36:139-144.
    • (1984) Cell , vol.36 , pp. 139-144
    • Mellor, A.L.1    Weiss, E.H.2    Kress, M.3    Jay, G.4    Flavell, R.A.5
  • 34
    • 0022337375 scopus 로고
    • Structure and expression of genes encoding murine Qa-2 class I antigens
    • Mellor A.L., Antoniou J., Robinson P.J. Structure and expression of genes encoding murine Qa-2 class I antigens. Proc. Natl. Acad. Sci. USA 1985, 82:5920-5924.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5920-5924
    • Mellor, A.L.1    Antoniou, J.2    Robinson, P.J.3
  • 35
    • 0033563166 scopus 로고    scopus 로고
    • A model for the origin of TCR-alphabeta+ CD4-CD8- B220+ cells based on high affinity TCR signals
    • Mixter P.F., Russell J.Q., Morrissette G.J., Charland C., Aleman-Hoey D., Budd R.C. A model for the origin of TCR-alphabeta+ CD4-CD8- B220+ cells based on high affinity TCR signals. J.Immunol. 1999, 162:5747-5756.
    • (1999) J.Immunol. , vol.162 , pp. 5747-5756
    • Mixter, P.F.1    Russell, J.Q.2    Morrissette, G.J.3    Charland, C.4    Aleman-Hoey, D.5    Budd, R.C.6
  • 36
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran A.E., Holzapfel K.L., Xing Y., Cunningham N.R., Maltzman J.S., Punt J., Hogquist K.A. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J.Exp. Med. 2011, 208:1279-1289.
    • (2011) J.Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 37
    • 0027309199 scopus 로고
    • Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness
    • Ohteki T., MacDonald H.R. Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur. J. Immunol. 1993, 23:1251-1255.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1251-1255
    • Ohteki, T.1    MacDonald, H.R.2
  • 38
    • 84875635224 scopus 로고    scopus 로고
    • Importance of TAP-independent processing pathways
    • Oliveira C.C., van Hall T. Importance of TAP-independent processing pathways. Mol. Immunol. 2013, 55:113-116.
    • (2013) Mol. Immunol. , vol.55 , pp. 113-116
    • Oliveira, C.C.1    van Hall, T.2
  • 39
    • 38649139095 scopus 로고    scopus 로고
    • Comprehensive analysis of the functional TCR repertoire at the single-cell level
    • Ozawa T., Tajiri K., Kishi H., Muraguchi A. Comprehensive analysis of the functional TCR repertoire at the single-cell level. Biochem. Biophys. Res. Commun. 2008, 367:820-825.
    • (2008) Biochem. Biophys. Res. Commun. , vol.367 , pp. 820-825
    • Ozawa, T.1    Tajiri, K.2    Kishi, H.3    Muraguchi, A.4
  • 40
    • 0033588547 scopus 로고    scopus 로고
    • Selection and expansion of CD8alpha/alpha(1) Tcell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules
    • Park S.H., Guy-Grand D., Lemonnier F.A., Wang C.R., Bendelac A., Jabri B. Selection and expansion of CD8alpha/alpha(1) Tcell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J.Exp. Med. 1999, 190:885-890.
    • (1999) J.Exp. Med. , vol.190 , pp. 885-890
    • Park, S.H.1    Guy-Grand, D.2    Lemonnier, F.A.3    Wang, C.R.4    Bendelac, A.5    Jabri, B.6
  • 43
    • 0035575989 scopus 로고    scopus 로고
    • TCR/self-antigen interactions drive double-negative Tcell peripheral expansion and differentiation into suppressor cells
    • Priatel J.J., Utting O., Teh H.S. TCR/self-antigen interactions drive double-negative Tcell peripheral expansion and differentiation into suppressor cells. J.Immunol. 2001, 167:6188-6194.
    • (2001) J.Immunol. , vol.167 , pp. 6188-6194
    • Priatel, J.J.1    Utting, O.2    Teh, H.S.3
  • 44
    • 0028170171 scopus 로고
    • Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of Tcells
    • Regnault A., Cumano A., Vassalli P., Guy-Grand D., Kourilsky P. Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of Tcells. J.Exp. Med. 1994, 180:1345-1358.
    • (1994) J.Exp. Med. , vol.180 , pp. 1345-1358
    • Regnault, A.1    Cumano, A.2    Vassalli, P.3    Guy-Grand, D.4    Kourilsky, P.5
  • 45
    • 0025974008 scopus 로고
    • The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial Tcell receptor alpha/beta+ lymphocytes reveals a major extrathymic pathway of Tcell differentiation
    • Rocha B., Vassalli P., Guy-Grand D. The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial Tcell receptor alpha/beta+ lymphocytes reveals a major extrathymic pathway of Tcell differentiation. J.Exp. Med. 1991, 173:483-486.
    • (1991) J.Exp. Med. , vol.173 , pp. 483-486
    • Rocha, B.1    Vassalli, P.2    Guy-Grand, D.3
  • 47
    • 73949158437 scopus 로고    scopus 로고
    • Proteases in MHC class I presentation and cross-presentation
    • Rock K.L., Farfán-Arribas D.J., Shen L. Proteases in MHC class I presentation and cross-presentation. J.Immunol. 2010, 184:9-15.
    • (2010) J.Immunol. , vol.184 , pp. 9-15
    • Rock, K.L.1    Farfán-Arribas, D.J.2    Shen, L.3
  • 48
    • 0034741125 scopus 로고    scopus 로고
    • Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE)
    • Shires J., Theodoridis E., Hayday A.C. Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 2001, 15:419-434.
    • (2001) Immunity , vol.15 , pp. 419-434
    • Shires, J.1    Theodoridis, E.2    Hayday, A.C.3
  • 50
    • 0027787572 scopus 로고
    • T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas
    • Sydora B.C., Mixter P.F., Houlden B., Hershberg R., Levy R., Comay M., Bluestone J., Kronenberg M. T-cell receptor gamma delta diversity and specificity of intestinal intraepithelial lymphocytes: analysis of IEL-derived hybridomas. Cell. Immunol. 1993, 152:305-322.
    • (1993) Cell. Immunol. , vol.152 , pp. 305-322
    • Sydora, B.C.1    Mixter, P.F.2    Houlden, B.3    Hershberg, R.4    Levy, R.5    Comay, M.6    Bluestone, J.7    Kronenberg, M.8
  • 51
  • 52
    • 34250173017 scopus 로고    scopus 로고
    • A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins
    • Tiwari N., Garbi N., Reinheckel T., Moldenhauer G., Hämmerling G.J., Momburg F. A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins. J.Immunol. 2007, 178:7932-7942.
    • (2007) J.Immunol. , vol.178 , pp. 7932-7942
    • Tiwari, N.1    Garbi, N.2    Reinheckel, T.3    Moldenhauer, G.4    Hämmerling, G.J.5    Momburg, F.6
  • 54
    • 0026059298 scopus 로고
    • An unusual lineage of alpha/beta Tcells that contains autoreactive cells
    • von Boehmer H., Kirberg J., Rocha B. An unusual lineage of alpha/beta Tcells that contains autoreactive cells. J.Exp. Med. 1991, 174:1001-1008.
    • (1991) J.Exp. Med. , vol.174 , pp. 1001-1008
    • von Boehmer, H.1    Kirberg, J.2    Rocha, B.3
  • 56
    • 2942640089 scopus 로고    scopus 로고
    • Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells
    • Yamagata T., Mathis D., Benoist C. Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat. Immunol. 2004, 5:597-605.
    • (2004) Nat. Immunol. , vol.5 , pp. 597-605
    • Yamagata, T.1    Mathis, D.2    Benoist, C.3


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