메뉴 건너뛰기




Volumn 4, Issue , 2014, Pages

DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; HISTONE DEACETYLASE 4; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; PROTEIN; PROTEIN C1Q; PROTEIN ITGB2; PROTEIN SPI1; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; COMPLEMENT COMPONENT C1Q; DNA;

EID: 84907342884     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2014.70     Document Type: Article
Times cited : (206)

References (50)
  • 2
    • 84860712363 scopus 로고    scopus 로고
    • Patterns and rates of exonic de novo mutations in autism spectrum disorders
    • Stevens C, Lin C-F, Cook EH Jr, Newsham I, Samocha KE, Zhao T et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 2012; 485: 242-245.
    • (2012) Nature , vol.485 , pp. 242-245
    • Stevens, C.1    Lin, C.-F.2    Cook Jr., E.H.3    Newsham, I.4    Samocha, K.E.5    Zhao, T.6
  • 3
    • 82255192290 scopus 로고    scopus 로고
    • The conundrums of understanding genetic risks for autism spectrum disorders
    • Levitt P, State MW. The conundrums of understanding genetic risks for autism spectrum disorders. Nat Neurosci 2011; 14: 1499-1506.
    • (2011) Nat Neurosci , vol.14 , pp. 1499-1506
    • Levitt, P.1    State, M.W.2
  • 4
    • 79952597943 scopus 로고    scopus 로고
    • Autism spectrum disorders and autistic traits: A decade of new twin studies
    • Ronald A, Hoekstra RA. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am J Med Genet B Neuropsychiatr Genet 2011; 156B: 255-274.
    • (2011) Am J Med Genet B Neuropsychiatr Genet , vol.156 B , pp. 255-274
    • Ronald, A.1    Hoekstra, R.A.2
  • 6
    • 70349856176 scopus 로고    scopus 로고
    • Diagnostic change and the increased prevalence of autism
    • King M, Bearman P. Diagnostic change and the increased prevalence of autism. Int J Epidemiol 2009; 38: 1224-1234.
    • (2009) Int J Epidemiol , vol.38 , pp. 1224-1234
    • King, M.1    Bearman, P.2
  • 7
    • 79954487837 scopus 로고    scopus 로고
    • Socioeconomic status and the increased prevalence of autism in California
    • Bearman PS, King MD. Socioeconomic status and the increased prevalence of autism in California. Am Sociol Rev 2011; 76: 320-346.
    • (2011) Am Sociol Rev , vol.76 , pp. 320-346
    • Bearman, P.S.1    King, M.D.2
  • 11
    • 79960118297 scopus 로고    scopus 로고
    • A genomic point-of-view on environmental factors influencing the human brain methylome
    • LaSalle JM. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics 2011; 6: 862-869.
    • (2011) Epigenetics , vol.6 , pp. 862-869
    • LaSalle, J.M.1
  • 12
    • 77958524817 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation in neurons: Enzymes, stimuli and signaling pathways
    • Riccio A. Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat Neurosci 2010; 13: 1330-1337.
    • (2010) Nat Neurosci , vol.13 , pp. 1330-1337
    • Riccio, A.1
  • 13
    • 84876686460 scopus 로고    scopus 로고
    • From neural development to cognition: Unexpected roles for chromatin
    • Ronan JL, Wu W, Crabtree GR. From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet 2013; 14: 347-359.
    • (2013) Nat Rev Genet , vol.14 , pp. 347-359
    • Ronan, J.L.1    Wu, W.2    Crabtree, G.R.3
  • 14
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl- CpG-binding protein 2
    • DOI 10.1038/13810
    • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999; 23: 185-188. (Pubitemid 29455390)
    • (1999) Nature Genetics , vol.23 , Issue.2 , pp. 185-188
    • Amir, R.E.1    Van Den, V.I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 15
    • 84897116665 scopus 로고    scopus 로고
    • Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    • Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC et al. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry 2013; 1-9.
    • (2013) Mol Psychiatry , pp. 1-9
    • Wong, C.C.Y.1    Meaburn, E.L.2    Ronald, A.3    Price, T.S.4    Jeffries, A.R.5    Schalkwyk, L.C.6
  • 17
    • 84863247768 scopus 로고    scopus 로고
    • Epigenetic signatures of autism: Trimethylated H3K4 landscapes in prefrontal neurons
    • Shulha HP, Lin CL, Guo Y, Lessard A, Akbarian S, Virgil D et al. Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons. Arch Gen Psychiatry 2012; 69: 314-324.
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 314-324
    • Shulha, H.P.1    Lin, C.L.2    Guo, Y.3    Lessard, A.4    Akbarian, S.5    Virgil, D.6
  • 19
    • 84901254866 scopus 로고    scopus 로고
    • The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism
    • Di Martino A, Yan C-G, Li Q, Denio E, Castellanos FX, Alaerts K et al. The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol Psychiatry 2013; 1-9.
    • (2013) Mol Psychiatry , pp. 1-9
    • Di Martino, A.1    Yan, C.-G.2    Li, Q.3    Denio, E.4    Castellanos, F.X.5    Alaerts, K.6
  • 20
    • 68149141820 scopus 로고    scopus 로고
    • Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults
    • Di Martino A, Shehzad Z, Kelly C, Roy AK, Gee DG, Uddin LQ et al. Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults. Am J Psychiatry 2009; 166 : 891-899.
    • (2009) Am J Psychiatry , vol.166 , pp. 891-899
    • Di Martino, A.1    Shehzad, Z.2    Kelly, C.3    Roy, A.K.4    Gee, D.G.5    Uddin, L.Q.6
  • 21
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6
  • 23
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    • Chen Y, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 2013; 8: 203-209.
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.1    Lemire, M.2    Choufani, S.3    Butcher, D.T.4    Grafodatskaya, D.5    Zanke, B.W.6
  • 24
    • 84862266444 scopus 로고    scopus 로고
    • Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation
    • Tost J, Touleimat N. Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics 2012; 4: 325-341.
    • (2012) Epigenomics , vol.4 , pp. 325-341
    • Tost, J.1    Touleimat, N.2
  • 25
    • 40449141013 scopus 로고    scopus 로고
    • What is principal component analysis?
    • DOI 10.1038/nbt0308-303, PII NBT0308303
    • Ringnér M. What is principal component analysis? Nat Biotechnol 2008; 26: 303-304. (Pubitemid 351355122)
    • (2008) Nature Biotechnology , vol.26 , Issue.3 , pp. 303-304
    • Ringner, M.1
  • 27
    • 79959262465 scopus 로고    scopus 로고
    • Transcriptomic analysis of autistic brain reveals convergent molecular pathology
    • Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 2011; 474: 380-384.
    • (2011) Nature , vol.474 , pp. 380-384
    • Voineagu, I.1    Wang, X.2    Johnston, P.3    Lowe, J.K.4    Tian, Y.5    Horvath, S.6
  • 28
    • 84875700729 scopus 로고    scopus 로고
    • A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
    • Guintivano J, Aryee MJ, Kaminsky ZA. A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression. Epigenetics 2013; 8: 290-302.
    • (2013) Epigenetics , vol.8 , pp. 290-302
    • Guintivano, J.1    Aryee, M.J.2    Kaminsky, Z.A.3
  • 29
    • 84869046060 scopus 로고    scopus 로고
    • HDAC4 governs a transcriptional program essential for synaptic plasticity and memory
    • Sando R, Gounko N, Pieraut S, Liao L, Yates J, Maximov A. HDAC4 governs a transcriptional program essential for synaptic plasticity and memory. Cell 2012; 151: 821-834.
    • (2012) Cell , vol.151 , pp. 821-834
    • Sando, R.1    Gounko, N.2    Pieraut, S.3    Liao, L.4    Yates, J.5    Maximov, A.6
  • 30
    • 77955584378 scopus 로고    scopus 로고
    • Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems
    • Williams SR, Aldred MA, Der Kaloustian VM, Halal F, Gowans G, McLeod DR et al. Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems. Am J Hum Genet 2010; 87: 219-228.
    • (2010) Am J Hum Genet , vol.87 , pp. 219-228
    • Williams, S.R.1    Aldred, M.A.2    Der Kaloustian, V.M.3    Halal, F.4    Gowans, G.5    McLeod, D.R.6
  • 31
    • 84878004354 scopus 로고    scopus 로고
    • Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance
    • Martino D, Loke YJ, Gordon L, Ollikainen M, Cruickshank MN, Saffery R et al. Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol 2013; 14: R42.
    • (2013) Genome Biol , vol.14
    • Martino, D.1    Loke, Y.J.2    Gordon, L.3    Ollikainen, M.4    Cruickshank, M.N.5    Saffery, R.6
  • 34
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: Roles in mammalian development
    • Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet 2013; 14: 204-220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 35
    • 84873322584 scopus 로고    scopus 로고
    • Peripheral and central inflammation in autism spectrum disorders
    • Depino AM. Peripheral and central inflammation in autism spectrum disorders. Mol Cell Neurosci 2013; 53: 69-76.
    • (2013) Mol Cell Neurosci , vol.53 , pp. 69-76
    • Depino, A.M.1
  • 36
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    • Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 2013; 16: 273-280.
    • (2013) Nat Neurosci , vol.16 , pp. 273-280
    • Kierdorf, K.1    Erny, D.2    Goldmann, T.3    Sander, V.4    Schulz, C.5    Perdiguero, E.G.6
  • 37
    • 84861123981 scopus 로고    scopus 로고
    • IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype
    • Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T et al. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep 2012; 1: 334-340.
    • (2012) Cell Rep , vol.1 , pp. 334-340
    • Masuda, T.1    Tsuda, M.2    Yoshinaga, R.3    Tozaki-Saitoh, H.4    Ozato, K.5    Tamura, T.6
  • 38
  • 39
    • 84876939061 scopus 로고    scopus 로고
    • Layer V cortical neurons require microglial support for survival during postnatal development
    • Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 2013; 16: 543-551.
    • (2013) Nat. Neurosci. , vol.16 , pp. 543-551
    • Ueno, M.1    Fujita, Y.2    Tanaka, T.3    Nakamura, Y.4    Kikuta, J.5    Ishii, M.6
  • 40
    • 84872176512 scopus 로고    scopus 로고
    • Microglia: New roles for the synaptic stripper
    • Kettenmann H, Kirchhoff F, Verkhratsky A. Microglia: new roles for the synaptic stripper. Neuron 2013; 77 : 10-18.
    • (2013) Neuron , vol.77 , pp. 10-18
    • Kettenmann, H.1    Kirchhoff, F.2    Verkhratsky, A.3
  • 42
    • 84896692474 scopus 로고    scopus 로고
    • Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
    • Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F et al. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci 2014; 17: 400-406.
    • (2014) Nat Neurosci , vol.17 , pp. 400-406
    • Zhan, Y.1    Paolicelli, R.C.2    Sforazzini, F.3    Weinhard, L.4    Bolasco, G.5    Pagani, F.6
  • 44
  • 46
    • 84892516407 scopus 로고    scopus 로고
    • Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3
    • Perez-Alcazar M, Daborg J, Stokowska A, Wasling P, Björefeldt A, Kalm M et al. Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3. Exp Neurol 2014; 253: 154-164.
    • (2014) Exp Neurol , vol.253 , pp. 154-164
    • Perez-Alcazar, M.1    Daborg, J.2    Stokowska, A.3    Wasling, P.4    Björefeldt, A.5    Kalm, M.6
  • 47
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-alpha
    • Stellwagen D, Malenka RC. Synaptic scaling mediated by glial TNF-alpha. Nature 2006; 440: 1054-1059.
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 49
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 2010; 13: 423-430.
    • (2010) Nat Neurosci , vol.13 , pp. 423-430
    • Feng, J.1    Zhou, Y.2    Campbell, S.L.3    Le, T.4    Li, E.5    Sweatt, J.D.6
  • 50
    • 84892595268 scopus 로고    scopus 로고
    • Prenatal poly(I:C) exposure and other developmental immune activation models in rodent systems
    • Meyer U. Prenatal poly(I:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry 2013; 1-9.
    • (2013) Biol Psychiatry , pp. 1-9
    • Meyer, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.