Safety and efficacy of intra-articular injection of tranexamic acid in total knee arthroplasty

Orthopedics

Volumn 37, Issue 9, 2014, Pages e775-e782

  Zhang, Yuan ^a   Fu, Xin ^b   Liu, Wen Xing ^a   Li, Yao Min ^b   Ma, Xin Long ^a,b   Li, Zhi Jun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Internal Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLOOD TRANSFUSION; COMPRESSION STOCKING; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; HEMOGLOBIN BLOOD LEVEL; HUMAN; KINESIOTHERAPY; LUNG EMBOLISM; META ANALYSIS; OPERATIVE BLOOD LOSS; PEROPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SURGICAL DRAINAGE; SYSTEMATIC REVIEW; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME; WALKING AID; BLOOD LOSS, SURGICAL; INTRAARTICULAR DRUG ADMINISTRATION; KNEE ARTHROPLASTY;

ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; HUMANS; INJECTIONS, INTRA-ARTICULAR; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANEXAMIC ACID;

EID: 84907280313     PISSN: 01477447     EISSN: 19382367     Source Type: Journal    
DOI: 10.3928/01477447-20140825-53     Document Type: Review

References (40)

1. Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am. 1999; 81(1):2-10.
2. Slappendel R. Risks associated with blood transfusion after total knee arthroplasty. J Arthroplasty. 2005; 20(3):407.
3. Bong MR, Patel V, Chang E, Issack PS, Hebert R, Di Cesare PE. Risks associated with blood transfusion after total knee arthroplasty. J Arthroplasty. 2004; 19(3):281-287.
4. Kalairajah Y, Simpson D, Cossey AJ, Verrall GM, Spriggins AJ. Blood loss after total knee replacement: effects of computer-assisted surgery. J Bone Joint Surg Br. 2005; 87(11):1480-1482.
5. Fiebig E. Safety of the blood supply. Clin Orthop Relat Res. 1998; (357):6-18.
6. Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009; 113(15):3406-3417.
7. Li B, Wen Y, Wu H, Qian Q, Lin X, Zhao H. The effect of tourniquet use on hidden blood loss in total knee arthroplasty. Int Orthop. 2009; 33(5):1263-1268.
8. Benoni G, Carlsson A, Petersson C, Fredin H. Does tranexamic acid reduce blood loss in knee arthroplasty? Am J Knee Surg. 1995; 8(3):88-92.
9. Delanois RE, Mont MA. Does tranexamic acid reduce blood loss in total knee arthroplasty? Commentary on an article by X. Aguilera, MD, et al: "Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty: a randomized controlled clinical trial." J Bone Joint Surg Am. 2013; 95(22):e179.
10. Akizuki S, Yasukawa Y, Takizawa T. A new method of hemostasis for cementless total knee arthroplasty. Bull Hosp Jt Dis. 1997; 56(4):222-224.
11. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth. 2003; 90(5):596-599.
12. Hiippala S, Strid L, Wennerstrand M, et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth. 1995; 74(5):534-537.
13. Veien M, Sorensen JV, Madsen F, Juelsgaard P. Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand. 2002; 46(10):1206-1211.
14. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res. 2009; 123(5):687-696.
15. Orpen NM, Little C, Walker G, Crawfurd EJ. Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee. 2006; 13(2):106-110.
16. Li ZJ, Fu X, Xing D, Zhang HF, Zang JC, Ma XL. Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J. 2013; 22(9):1950-1957.
17. Ishida K, Tsumura N, Kitagawa A, et al. Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop. 2011; 35(11):1639-1645.
18. Sa-Ngasoongsong P, Channoom T, Kawinwonggowit V, et al. Postoperative blood loss reduction in computer-assisted surgery total knee replacement by low dose intra-articular tranexamic acid injection together with 2-hour clamp drain: a prospective tripleblinded randomized controlled trial. Orthop Rev (Pavia). 2011; 3(2):e12.
19. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414):557-560.
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-188.
21. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med. 1997; 127(9):820-826.
22. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700.
23. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009; 339:b2535.
24. Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A. Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. J Arthroplasty. 2012; 27(1):105-108.
25. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res. 2012; 470(9):2605-2612.
26. Wong J, Abrishami A, El Beheiry H, et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am. 2010; 92(15):2503-2513.
27. Alshryda S, Mason J, Vaghela M, et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K). J Bone Joint Surg Am. 2013; 95(21):1961-1968.
28. Georgiadis AG, Muh SJ, Silverton CD, Weir RM, Laker MW. A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty. J Arthroplasty. 2013; 28(8 suppl):78-82.
29. Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON. Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2012; 20(12):2494-2501.
30. Seo JG, Moon YW, Park SH, Kim SM, Ko KR. The comparative efficacies of intraarticular and IV tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2013; 21(8):1869-1874.
31. Arnold DM, Fergusson DA, Chan AK, et al. Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin. Anesth Analg. 2006; 102(3):731-737.
32. Zufferey P, Merquiol F, Laporte S, et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology. 2006; 105(5):1034-1046.
33. Alshryda S, Sarda P, Sukeik M, Nargol A, Blenkinsopp J, Mason JM. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br. 2011; 93(12):1577-1585.
34. Charoencholvanich K, Siriwattanasakul P. Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clin Orthop Relat Res. 2011; 469(10):2874-2880.
35. Cid J, Lozano M. Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion. 2005; 45(8):1302-1307.
36. Behrman MJ, Keim HA. Perioperative red blood cell salvage in spine surgery: a prospective analysis. Clin Orthop Relat Res. 1992; (278):51-57.
37. Nuttall GA, Horlocker TT, Santrach PJ, Oliver WC Jr, Dekutoski MB, Bryant S. Predictors of blood transfusions in spinal instrumentation and fusion surgery. Spine (Phila Pa 1976). 2000; 25(5):596-601.
38. Tate DE Jr, Friedman RJ. Blood conservation in spinal surgery: review of current techniques. Spine (Phila Pa 1976). 1992; 17(12):1450-1456.
39. Mutsuzaki H, Ikeda K. Intra-articular injection of tranexamic acid via a drain plus drainclamping to reduce blood loss in cementless total knee arthroplasty. J Orthop Surg Res. 2012; 7:32.
40. Gillette BP, DeSimone LJ, Trousdale RT, Pagnano MW, Sierra RJ. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty. Clin Orthop Relat Res. 2013; 471(1):150-154.