Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of twist and the transforming growth factor β (TGF-β)-snail signaling axis

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26038-26056

  Chanmee, Theerawut ^a   Ontong, Pawared ^a   Mochizuki, Nobutoshi ^a   Kongtawelert, Prachya ^b   Konno, Kenjiro ^a   Itano, Naoki ^a  

^a KYOTO SANGYO UNIVERSITY   (Japan)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CYTOLOGY; DISEASES; HYALURONIC ACID; MOLLUSCS; STEM CELLS;

BREAST CANCER; CANCER CELLS; CANCER STEM CELLS; CELL STATE; HYALURONAN; HYALURONAN PRODUCTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

CELL SIGNALING;

CD24 ANTIGEN; HERMES ANTIGEN; HYALURONIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; GLUCURONOSYLTRANSFERASE; HAS2 PROTEIN, MOUSE; NUCLEAR PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TWIST1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GROWTH; CANCER STEM CELL; CARBOHYDRATE SYNTHESIS; CELL STRUCTURE; CELL SUBPOPULATION; CELL VIABILITY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE; GENE OVEREXPRESSION; GENE SILENCING; HAS2 GENE; HYALURONAN OVERPRODUCTION; INTRACELLULAR SIGNALING; MAMMOSPHERE FORMATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; PHENOTYPIC PLASTICITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STEM CELL EXPANSION; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL PROLIFERATION; ENZYME INDUCTION; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ANIMALS; CELL PROLIFERATION; ENZYME INDUCTION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GLUCURONOSYLTRANSFERASE; HUMANS; HYALURONIC ACID; MAMMARY NEOPLASMS, EXPERIMENTAL; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MICE, NUDE; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TWIST TRANSCRIPTION FACTOR;

EID: 84907270573     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.564120     Document Type: Article

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