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Volumn 24, Issue 10, 2014, Pages 1067-1075

Deuterated drugs: Where are we now?

Author keywords

deuteration; metabolism; obviousness; patent

Indexed keywords

DEUTERATED DRUGS; DEUTERIUM; DRUG; UNCLASSIFIED DRUG;

EID: 84907262678     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2014.943184     Document Type: Review
Times cited : (145)

References (100)
  • 3
    • 79960986705 scopus 로고    scopus 로고
    • Deuterated drugs: Unexpectedly nonobvious
    • Buteau KC. Deuterated drugs: unexpectedly nonobvious. J High Tech L 2009; 10: 22
    • (2009) J High Tech L , vol.10 , pp. 22
    • Buteau, K.C.1
  • 4
    • 84900296719 scopus 로고    scopus 로고
    • Using deuterium in drug discovery: Leaving the label in the drug
    • Gant TG. Using deuterium in drug discovery: leaving the label in the drug. J Med Chem 2013; 57 (9): 3595-611
    • (2013) J Med Chem , vol.57 , Issue.9 , pp. 3595-3611
    • Gant, T.G.1
  • 5
    • 0022996558 scopus 로고
    • Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine
    • Darland GK, Hajdu R, Kropp H, et al. Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Drug Metab Dispos 1986; 14 (6): 668-73
    • (1986) Drug Metab Dispos , vol.14 , Issue.6 , pp. 668-673
    • Darland, G.K.1    Hajdu, R.2    Kropp, H.3
  • 11
    • 62649157778 scopus 로고    scopus 로고
    • Big interest in heavy drugs
    • Sanderson K. Big interest in heavy drugs. Nature 2009; 458 (7236): 269
    • (2009) Nature , vol.458 , Issue.7236 , pp. 269
    • Sanderson, K.1
  • 12
    • 84880994816 scopus 로고    scopus 로고
    • Heavy drugs draw heavy interest from pharma backers
    • Katsnelson A. Heavy drugs draw heavy interest from pharma backers. Nat Med 2013; 19 (6): 656
    • (2013) Nat Med , vol.19 , Issue.6 , pp. 656
    • Katsnelson, A.1
  • 14
    • 0022571936 scopus 로고
    • Effects of deuterium substitution on the catabolism of beta-phenylethylamine: An in vivo study
    • Dyck LE, Durden DA, Boulton AA. Effects of deuterium substitution on the catabolism of beta-phenylethylamine: an in vivo study. J Neurochem 1986; 46 (2): 399-404
    • (1986) J Neurochem , vol.46 , Issue.2 , pp. 399-404
    • Dyck, L.E.1    Durden, D.A.2    Boulton, A.A.3
  • 15
    • 0023900362 scopus 로고
    • Effect of deuterium substitution on the penetration of beta-phenylethylhydrazine into the rat brain
    • Dewar KM, Dyck LE, Durden DA, et al. Effect of deuterium substitution on the penetration of beta-phenylethylhydrazine into the rat brain. Biochem Pharmacol 1988; 37 (13): 2703-4
    • (1988) Biochem Pharmacol , vol.37 , Issue.13 , pp. 2703-2704
    • Dewar, K.M.1    Dyck, L.E.2    Durden, D.A.3
  • 16
    • 0022872115 scopus 로고
    • Effect of deuterium substitution on the disposition of intraperitoneal tryptamine
    • Dyck LE, Boulton AA. Effect of deuterium substitution on the disposition of intraperitoneal tryptamine. Biochem Pharmacol 1986; 35 (17): 2893-6
    • (1986) Biochem Pharmacol , vol.35 , Issue.17 , pp. 2893-2896
    • Dyck, L.E.1    Boulton, A.A.2
  • 21
    • 0032772532 scopus 로고    scopus 로고
    • Pharmacological uses and perspectives of heavy water and deuterated compounds
    • Kushner D, Baker A, Dunstall T. Pharmacological uses and perspectives of heavy water and deuterated compounds. Can J Physiol Pharmacol 1999; 77 (2): 79-88
    • (1999) Can J Physiol Pharmacol , vol.77 , Issue.2 , pp. 79-88
    • Kushner, D.1    Baker, A.2    Dunstall, T.3
  • 23
    • 0019580182 scopus 로고
    • The use of stable isotopes in pharmacological research
    • Baillie TA. The use of stable isotopes in pharmacological research. Pharmacol Rev 1981; 33 (2): 81-132
    • (1981) Pharmacol Rev , vol.33 , Issue.2 , pp. 81-132
    • Baillie, T.A.1
  • 24
    • 0031894162 scopus 로고    scopus 로고
    • Stable isotope techniques in early drug development: An economic evaluation
    • Browne TR. Stable isotope techniques in early drug development: an economic evaluation. J Clin Pharmacol 1998; 38 (3): 213-20
    • (1998) J Clin Pharmacol , vol.38 , Issue.3 , pp. 213-220
    • Browne, T.R.1
  • 25
    • 0023444951 scopus 로고
    • Study of deuterium isotope effects on protein binding by gas chromatography/mass spectrometry Caffeine and deuterated isotopomers
    • Cherrah Y, Falconnet J, Desage M, et al. Study of deuterium isotope effects on protein binding by gas chromatography/mass spectrometry. Caffeine and deuterated isotopomers. Biol Mass Spectrom 1987; 14 (11): 653-7
    • (1987) Biol Mass Spectrom , vol.14 , Issue.11 , pp. 653-657
    • Cherrah, Y.1    Falconnet, J.2    Desage, M.3
  • 26
    • 0023835315 scopus 로고
    • Synthesis of deuterium-labelled elliptinium and its use in metabolic studies
    • Gouyette A. Synthesis of deuterium-labelled elliptinium and its use in metabolic studies. Biol Mass Spectrom 1988; 15 (5): 243-7
    • (1988) Biol Mass Spectrom , vol.15 , Issue.5 , pp. 243-247
    • Gouyette, A.1
  • 27
    • 0020427034 scopus 로고
    • The application of stable isotopes in biomedical research
    • Haskins N. The application of stable isotopes in biomedical research. Biol Mass Spectrom 1982; 9 (7): 269-77
    • (1982) Biol Mass Spectrom , vol.9 , Issue.7 , pp. 269-277
    • Haskins, N.1
  • 28
    • 0033324606 scopus 로고    scopus 로고
    • Moricizine bioavailability via simultaneous, dual, stable isotope administration: Bioequivalence implications
    • Pieniaszek HJ, Mayersohn M, Adams MP, et al. Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications. J Clin Pharmacol 1999; 39 (8): 817-25
    • (1999) J Clin Pharmacol , vol.39 , Issue.8 , pp. 817-825
    • Pieniaszek, H.J.1    Mayersohn, M.2    Adams, M.P.3
  • 29
    • 0027703593 scopus 로고
    • Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10) diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewest
    • Tonn G, Mutlib A, Abbott F, et al. Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10) diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewest. Biol Mass Spectrom 1993; 22 (11): 633-42
    • (1993) Biol Mass Spectrom , vol.22 , Issue.11 , pp. 633-642
    • Tonn, G.1    Mutlib, A.2    Abbott, F.3
  • 30
    • 0022639059 scopus 로고
    • The application of stable isotopes to studies of drug bioavailability and bioequivalence
    • Wolen RL. The application of stable isotopes to studies of drug bioavailability and bioequivalence. J Clin Pharmacol 1986; 26 (6): 419-24
    • (1986) J Clin Pharmacol , vol.26 , Issue.6 , pp. 419-424
    • Wolen, R.L.1
  • 34
    • 3142566595 scopus 로고
    • Investigations into the chemistry of thermodynamically unstable species. the direct polymerization of vinyl alcohol, the enolic tautomer of acetaldehyde
    • Cederstav AK, Novak BM. Investigations into the chemistry of thermodynamically unstable species. The direct polymerization of vinyl alcohol, the enolic tautomer of acetaldehyde. J Am Chem Soc 1994; 116 (9): 4073-4
    • (1994) J Am Chem Soc , vol.116 , Issue.9 , pp. 4073-4074
    • Cederstav, A.K.1    Novak, B.M.2
  • 35
    • 84892489056 scopus 로고    scopus 로고
    • A randomized phase i evaluation of CTP-499, a novel deuterium-containing drug candidate for diabetic nephropathy
    • Braman V, Graham P, Cheng C, et al. A randomized phase I evaluation of CTP-499, a novel deuterium-containing drug candidate for diabetic nephropathy. Clinical Pharmacology in Drug Development 2013; 2 (1): 53-66
    • (2013) Clinical Pharmacology in Drug Development , vol.2 , Issue.1 , pp. 53-66
    • Braman, V.1    Graham, P.2    Cheng, C.3
  • 36
    • 84857383845 scopus 로고    scopus 로고
    • Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs
    • Sharma R, Strelevitz TJ, Gao H, et al. Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs. Drug Metab Dispos 2012; 40 (3): 625-34
    • (2012) Drug Metab Dispos , vol.40 , Issue.3 , pp. 625-634
    • Sharma, R.1    Strelevitz, T.J.2    Gao, H.3
  • 37
    • 84877797463 scopus 로고    scopus 로고
    • The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite CGP74588
    • Manley PW, Blasco F, Mestan J, et al. The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588. Bioorg Med Chem 2013; 21 (11): 3231-9
    • (2013) Bioorg Med Chem , vol.21 , Issue.11 , pp. 3231-3239
    • Manley, P.W.1    Blasco, F.2    Mestan, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.