Moricizine bioavailability via simultaneous, dual, stable isotope administration: Bioequivalence implications

Journal of Clinical Pharmacology

Volumn 39, Issue 8, 1999, Pages 817-825

  Pieniaszek H J , Jr ^a   Mayersohn, M ^a   Adams, M P ^a   Reinhart, R J ^a   Barrett, J S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORACIZINE;

ADULT; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISPOSITION; FIRST PASS EFFECT; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MALE; NORMAL HUMAN; VARIANCE;

EID: 0033324606     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912709922008489     Document Type: Article

References (21)

1. Antiarrhythmic agents and their use in theapy
2. Disposition of moricizine (Ethmozine) in healthy subjects after oral administration of radiolabeled drug
3. Bioavailability of Ethmozine with oral administration (translation)
4. Influence of food on the oral absorption and bioavailability of moricizine
5. Bioavailability of imipramine tablets relative to stable isotope internal standard increasing the power of bioavailability tests
6. Application of stable labeled drugs in clinical investigations
7. 6-labeled moricizine in human plasma using thermospray liquid chromatography-mass spectrometry
8. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability
9. Presentation of variation for sample size planning in bioequivalence studies
10. Sample size determination for the two one-sided tests procedure in bioequivalence
11. Pharmacokinetic interactions of moricizine and diltiazem in healthy volunteers
12. Metabolism of drugs and other xenobiotics in gut lumen and wall
13. A tracer interaction method for nonlinear pharmacokinetics analysis: Application to evaluation of nonlinear elimination
14. Stable isotopes in clinical pharmacokinetic investigations: Advantages and disadvantages
15. Single-dose pharmacokinetics of terodiline, including a stable isotope technique for improvement of statistical evaluations
16. The application of stable isotopes to studies of drug bioavailability and bioequivalence
17. Use of stable isotopes technique to evaluate the bioavailability of a pharmaceutical form of magnesium in man
18. Absorption and bioequivalence
19. The statistical analysis of data from bioequivalence studies using stable isotopes
20. Stable isotope techniques in early drug development: An economic evaluation