Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis

Ophthalmology

Volumn 118, Issue 1, 2011, Pages 134-141

  Soheilian, Masoud ^a,b   Ramezani, Alireza ^a,b,c   Azimzadeh, Ahmad ^a,b   Sadoughi, Mohammad Mehdi ^a,b   Dehghan, Mohammad H ^a,b   Shahghadami, Reza ^a   Yaseri, Mehdi ^a   Peyman, Gholam A ^d  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Negah Eye Hospital   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; DEXAMETHASONE; FOLINIC ACID; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PREDNISOLONE; PYRIMETHAMINE; SULFADIAZINE;

ADULT; ARTICLE; BLOOD EXAMINATION; CHORIORETINOPATHY; CLINICAL TRIAL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE INFLAMMATION; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; RECURRENT DISEASE; THROMBOCYTOPENIA; TOXOPLASMOSIS; UNSPECIFIED SIDE EFFECT; VISUAL ACUITY; VITREOUS BODY;

ADULT; ANTIBODIES, PROTOZOAN; ANTIPROTOZOAL AGENTS; CLINDAMYCIN; DEXAMETHASONE; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOGLOBULIN M; INTRAVITREAL INJECTIONS; MALE; PREDNISOLONE; PROSPECTIVE STUDIES; PYRIMETHAMINE; SINGLE-BLIND METHOD; SULFADIAZINE; TOXOPLASMOSIS, OCULAR; TREATMENT OUTCOME; VISUAL ACUITY; YOUNG ADULT;

EID: 78650846839     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2010.04.020     Document Type: Article

References (30)

1. E.M. Dodds Ocular toxoplasmosis: clinical presentations, diagnosis and therapy Focal Points: Clinical Modules for Ophthalmologists 1999 American Academy of Ophthalmology San Francisco, CA 1 14
2. M. Soheilian, K. Heidari, and S. Yazdani Patterns of uveitis in a tertiary eye care center in Iran Ocul Immunol Inflamm 12 2004 297 310
3. A. Rothova, C. Meenken, and H.J. Buitenhuis Therapy for ocular toxoplasmosis Am J Ophthalmol 115 1993 517 523
4. G.N. Holland Reconsidering the pathogenesis of ocular toxoplasmosis Am J Ophthalmol 128 1999 502 505
5. K. Tabbara Toxoplasmosis W. Tasman, E. Jaeger, Duane's Clinical Ophthalmology 4 1995 LippincottRaven Philadelphia 1 21
6. E.S. Perkins Ocular toxoplasmosis Br J Ophthalmol 57 1973 1 17
7. W.G. Martin, G.C. Brown, and R.K. Parrish Ocular toxoplasmosis and visual field defects Am J Ophthalmol 90 1980 25 29
8. A. Hovakimyan, and E.T. Cunningham Jr Ocular toxoplasmosis Ophthalmol Clin North Am 15 2002 327 332
9. M.R. Stanford, S.E. See, L.V. Jones, and R.E. Gilbert Antibiotics for toxoplasmic retinochoroiditis: an evidence-based systematic review Ophthalmology 110 2003 926 931 quiz 312
10. M. Soheilian, M.M. Sadoughi, and M. Ghajarnia Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis Ophthalmology 112 2005 1876 1882
11. A. Rothova, L.E. Bosch-Driessen, N.H. van Loon, and W.F. Treffers Azithromycin for ocular toxoplasmosis Br J Ophthalmol 82 1998 1306 1308
12. J.S. Lopez, M.D. de Smet, and H. Masur Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome Am J Ophthalmol 113 1992 331 333
13. G.N. Holland, G.R. O'Conner, R. Belfort Jr, and J.S. Remington Toxoplasmosis J.S. Pepose, G.N. Holland, K.R. Wilhelmuis, Ocular Infection and Immunity 1996 Mosby St. Louis 1183 1223
14. K. Kishore, M.D. Conway, and G.A. Peyman Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis Ophthalmic Surg Lasers 32 2001 183 192
15. C.E. Martinez, D. Zhang, M.D. Conway, and G.A. Peyman Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine Int Ophthalmol 22 1998 85 88
16. L. Sobrin, L.I. Kump, and C.S. Foster Intravitreal clindamycin for toxoplasmic retinochoroiditis Retina 27 2007 952 957
17. R.A. Nozik Results of treatment of ocular toxoplasmosis with injectable corticosteroids Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol 83 1977 811 818
18. G.R. O'Connor Manifestations and management of ocular toxoplasmosis Bull N Y Acad Med 50 1974 192 210
19. B.S. Elkins, G.N. Holland, and E.M. Opremcak Ocular toxoplasmosis misdiagnosed as cytomegalovirus retinopathy in immunocompromised patients Ophthalmology 101 1994 499 507
20. J.G. Ferguson Jr Clindamycin therapy for toxoplasmosis Ann Ophthalmol 13 1981 95 100
21. J.T. Paquejt, and G.A. Peyman Intravitreal clindamycin phosphate in the treatment of vitreous infection Ophthalmic Surg 5 1974 34 39
22. G.A. Peyman, H.C. Charles, and K.R. Liu Intravitreal liposome- encapsulated drugs: a preliminary human report Int Ophthalmol 12 1988 175 182
23. J.J. Kanski Clinical ophthalmology 4th ed 1999 Butterworth-Heinemann Ltd Oxford 263 319
24. S.J. Kimura, P. Thygeson, and M.J. Hogan Signs and symptoms of uveitis II. Classification of the posterior manifestations of uveitis Am J Ophthalmol 47 1959 171 176
25. G.L. Mandell, and E. Coleman Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils Antimicrob Agents Chemother 45 2001 1794 1798
26. G.A. Peyman, P.J. Lee, and D. Seal Endophthalmitis Diagnosis and Management 2004 Taylor & Francis 81 100
27. G.R. O'Connor, and J.K. Frenkel Dangers of steroid treatment in toxoplasmosis Periocular injections and systemic therapy [editorial] Arch Ophthalmol 94 1976 213
28. J. Soto Clindamycin and pseudomembranous colitis Lancet 346 1995 249
29. V. Thamlikitkul, K. Danpakdi, and S. Chokloikaew Incidence of diarrhea and Clostridium difficile toxin in stools from hospitalized patients receiving clindamycin, beta-lactams, or nonantibiotic medications J Clin Gastroenterol 22 1996 161 163
30. B.S. Morgan, B. Larson, G.A. Peyman, and C.S. West Toxicity of antibiotic combinations for vitrectomy infusion fluid Ophthalmic Surg 10 1979 74 77