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Volumn 11, Issue 8, 2014, Pages 7993-8009

Antibiotic use and misuse during pregnancy and delivery: Benefits and risks

Author keywords

Antibiotics; Fetal; Infant; Morbidity; Neonatal; Pregnancy; Risk

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; ERYTHROMYCIN; METRONIDAZOLE; PLACEBO; ANTIINFECTIVE AGENT;

EID: 84907259761     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph110807993     Document Type: Review
Times cited : (95)

References (119)
  • 1
    • 33646814764 scopus 로고    scopus 로고
    • Antibiotic use in pregnancy and lactation: What is and is not known about teratogenic and toxic risks
    • Nahum, G.G.; Uhl, K.; Kennedy, D.L. Antibiotic use in pregnancy and lactation: What is and is not known about teratogenic and toxic risks. Obstet. Gynecol. 2006, 107, 1120-1138.
    • (2006) Obstet. Gynecol , vol.107 , pp. 1120-1138
    • Nahum, G.G.1    Uhl, K.2    Kennedy, D.L.3
  • 2
    • 84886915564 scopus 로고    scopus 로고
    • Are we using too many antibiotics during pregnancy?
    • Ledger, W.J.; Blaser, M.J. Are we using too many antibiotics during pregnancy? BJOG 2013, 120, 1450-1452.
    • (2013) BJOG , vol.120 , pp. 1450-1452
    • Ledger, W.J.1    Blaser, M.J.2
  • 3
    • 78649605964 scopus 로고    scopus 로고
    • Prevention of perinatal group B streptococcal disease-Revised guidelines from CDC, 2010
    • Verani, J.R.; McGee, L.; Schrag, S.J. Prevention of perinatal group B streptococcal disease-Revised guidelines from CDC, 2010. MMWR Recomm. Rep. 2010, 59, 1-36.
    • (2010) MMWR Recomm. Rep , vol.59 , pp. 1-36
    • Verani, J.R.1    McGee, L.2    Schrag, S.J.3
  • 6
    • 84875272832 scopus 로고    scopus 로고
    • Arriving too early
    • Marcos, Z. Arriving too early. Lancet Neurol. 2013, 12, 332-333.
    • (2013) Lancet Neurol , vol.12 , pp. 332-333
    • Marcos, Z.1
  • 8
    • 84872586238 scopus 로고    scopus 로고
    • Preventing preterm births: Analysis of trends and potential reductions with interventions in 39 countries with very high human development index
    • Chang, H.H.; Larson, J.; Blencowe, H.; Spong, C.Y.; Howson, C.P.; Cairns-Smith, S.; Lackritz, E.M.; Lee, S.K.; Mason, E.; Serazin, A.C.; et al. Preventing preterm births: Analysis of trends and potential reductions with interventions in 39 countries with very high human development index. Lancet 2013, 381, 223-234.
    • (2013) Lancet , vol.381 , pp. 223-234
    • Chang, H.H.1    Larson, J.2    Blencowe, H.3    Spong, C.Y.4    Howson, C.P.5    Cairns-Smith, S.6    Lackritz, E.M.7    Lee, S.K.8    Mason, E.9    Serazin, A.C.10
  • 9
    • 0037218995 scopus 로고    scopus 로고
    • Preterm premature rupture of the membranes
    • Mercer, B.M. Preterm premature rupture of the membranes. Obstet. Gynecol. 2003, 101, 178-193.
    • (2003) Obstet. Gynecol , vol.101 , pp. 178-193
    • Mercer, B.M.1
  • 10
    • 84891371339 scopus 로고    scopus 로고
    • Economic analysis of the costs associated with prematurity from a literature review
    • Soilly, A.L.; Lejeune, C.; Quantin, C.; Bejean, S.; Gouyon, J.B. Economic analysis of the costs associated with prematurity from a literature review. Public Health 2014, 128, 43-62.
    • (2014) Public Health , vol.128 , pp. 43-62
    • Soilly, A.L.1    Lejeune, C.2    Quantin, C.3    Bejean, S.4    Gouyon, J.B.5
  • 11
    • 0141990508 scopus 로고    scopus 로고
    • The cost of prematurity: Quantification by gestational age and birth weight
    • Gilbert, W.M.; Nesbitt, T.S.; Danielsen, B. The cost of prematurity: Quantification by gestational age and birth weight. Obstet. Gynecol. 2003, 102, 488-492.
    • (2003) Obstet. Gynecol , vol.102 , pp. 488-492
    • Gilbert, W.M.1    Nesbitt, T.S.2    Danielsen, B.3
  • 12
    • 77952765114 scopus 로고    scopus 로고
    • The enigma of spontaneous preterm birth
    • Takayama, J.I.; Matsuo, N. The enigma of spontaneous preterm birth. N. Engl. J. Med. 2010, 362, 2032-2033.
    • (2010) N. Engl. J. Med , vol.362 , pp. 2032-2033
    • Takayama, J.I.1    Matsuo, N.2
  • 13
    • 33748609380 scopus 로고    scopus 로고
    • Preterm birth due to maternal infection: Causative pathogens and modes of prevention
    • Pararas, M.V.; Skevaki, C.L.; Kafetzis, D.A. Preterm birth due to maternal infection: Causative pathogens and modes of prevention. Eur. J. Clin. Microbiol. Infect. Dis. 2006, 25, 562-569.
    • (2006) Eur. J. Clin. Microbiol. Infect. Dis , vol.25 , pp. 562-569
    • Pararas, M.V.1    Skevaki, C.L.2    Kafetzis, D.A.3
  • 16
    • 16644383429 scopus 로고    scopus 로고
    • A review of the role of proinflammatory cytokines in labor and noninfectious preterm labor
    • Farina, L.; Winkelman, C. A review of the role of proinflammatory cytokines in labor and noninfectious preterm labor. Biol. Res. Nurs. 2005, 6, 230-238.
    • (2005) Biol. Res. Nurs , vol.6 , pp. 230-238
    • Farina, L.1    Winkelman, C.2
  • 17
    • 77955134176 scopus 로고    scopus 로고
    • Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: A systematic review
    • Wei, S.Q.; Fraser, W.; Luo, Z.C. Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: A systematic review. Obstet. Gynecol. 2010, 116, 393-401.
    • (2010) Obstet. Gynecol , vol.116 , pp. 393-401
    • Wei, S.Q.1    Fraser, W.2    Luo, Z.C.3
  • 18
    • 77949829611 scopus 로고    scopus 로고
    • Integrated review of cytokines in maternal, cord, and newborn blood: Part I-Associations with preterm birth
    • Lyon, D.; Cheng, C.Y.; Howland, L.; Rattican, D.; Jallo, N.; Pickler, R.; Brown, L.; McGrath, J. Integrated review of cytokines in maternal, cord, and newborn blood: Part I-Associations with preterm birth. Biol. Res. Nurs. 2010, 11, 371-376.
    • (2010) Biol. Res. Nurs , vol.11 , pp. 371-376
    • Lyon, D.1    Cheng, C.Y.2    Howland, L.3    Rattican, D.4    Jallo, N.5    Pickler, R.6    Brown, L.7    McGrath, J.8
  • 19
    • 0032005870 scopus 로고    scopus 로고
    • Maternal serum interleukin-6 concentration as a marker for impending preterm delivery
    • Murtha, A.P.; Greig, P.C.; Jimmerson, C.E.; Herbert, W.N. Maternal serum interleukin-6 concentration as a marker for impending preterm delivery. Obstet. Gynecol. 1998, 91, 161-164.
    • (1998) Obstet. Gynecol , vol.91 , pp. 161-164
    • Murtha, A.P.1    Greig, P.C.2    Jimmerson, C.E.3    Herbert, W.N.4
  • 20
    • 34547953208 scopus 로고    scopus 로고
    • Maternal serum proinflammatory cytokines in preterm labor with intact membranes: Neonatal outcome and histological associations
    • Torbe, A.; Czajka, R.; Kordek, A.; Rzepka, R.; Kwiatkowski, S.; Rudnicki, J. Maternal serum proinflammatory cytokines in preterm labor with intact membranes: Neonatal outcome and histological associations. Eur. Cytokine Netw. 2007, 18, 102-107.
    • (2007) Eur. Cytokine Netw , vol.18 , pp. 102-107
    • Torbe, A.1    Czajka, R.2    Kordek, A.3    Rzepka, R.4    Kwiatkowski, S.5    Rudnicki, J.6
  • 23
    • 80052225673 scopus 로고    scopus 로고
    • Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: A systematic review and metaanalysis
    • Lamont, R.F.; Nhan-Chang, C.L.; Sobel, J.D.; Workowski, K.; Conde-Agudelo, A.; Romero, R. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: A systematic review and metaanalysis. Amer. J. Obstet. Gynecol. 2011, 205, 177-190.
    • (2011) Amer. J. Obstet. Gynecol , vol.205 , pp. 177-190
    • Lamont, R.F.1    Nhan-Chang, C.L.2    Sobel, J.D.3    Workowski, K.4    Conde-Agudelo, A.5    Romero, R.6
  • 24
    • 0035978066 scopus 로고    scopus 로고
    • Broad-spectrum antibiotics for spontaneous preterm labour: The ORACLE II randomised trial. ORACLE Collaborative Group
    • Kenyon, S.L.; Taylor, D.J.; Tarnow-Mordi, W. Broad-spectrum antibiotics for spontaneous preterm labour: The ORACLE II randomised trial. ORACLE Collaborative Group. Lancet 2001, 357, 989-994.
    • (2001) Lancet , vol.357 , pp. 989-994
    • Kenyon, S.L.1    Taylor, D.J.2    Tarnow-Mordi, W.3
  • 25
    • 84897368232 scopus 로고    scopus 로고
    • Prophylactic antibiotics for inhibiting preterm labour with intact membranes
    • doi:10.1002/14651858.CD000246
    • Flenady, V.; Hawley, G.; Stock, O.M.; Kenyon, S.; Badawi, N. Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database Syst. Rev. 2013, 12, doi:10.1002/14651858.CD000246.
    • (2013) Cochrane Database Syst. Rev , vol.12
    • Flenady, V.1    Hawley, G.2    Stock, O.M.3    Kenyon, S.4    Badawi, N.5
  • 26
    • 53249154636 scopus 로고    scopus 로고
    • Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial
    • Kenyon, S.; Pike, K.; Jones, D.R.; Brocklehurst, P.; Marlow, N.; Salt, A.; Taylor, D.J. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 2008, 372, 1319-1327.
    • (2008) Lancet , vol.372 , pp. 1319-1327
    • Kenyon, S.1    Pike, K.2    Jones, D.R.3    Brocklehurst, P.4    Marlow, N.5    Salt, A.6    Taylor, D.J.7
  • 27
    • 0035978074 scopus 로고    scopus 로고
    • Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: The ORACLE I randomised trial
    • Kenyon, S.L.; Taylor, D.J.; Tarnow-Mordi, W. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: The ORACLE I randomised trial. Lancet 2001, 357, 979-988.
    • (2001) Lancet , vol.357 , pp. 979-988
    • Kenyon, S.L.1    Taylor, D.J.2    Tarnow-Mordi, W.3
  • 28
    • 84897368230 scopus 로고    scopus 로고
    • Antibiotics for preterm rupture of membranes
    • doi:10.1002/14651858.CD001058
    • Kenyon, S.; Boulvain, M.; Neilson, J.P. Antibiotics for preterm rupture of membranes. Cochrane Database Syst. Rev. 2013, 12, doi:10.1002/14651858.CD001058.
    • (2013) Cochrane Database Syst. Rev , vol.12
    • Kenyon, S.1    Boulvain, M.2    Neilson, J.P.3
  • 29
    • 84874815789 scopus 로고    scopus 로고
    • Antibiotics for treating bacterial vaginosis in pregnancy
    • doi:10.1002/14651858.CD000262.pub4
    • Brocklehurst, P.; Gordon, A.; Heatley, E.; Milan, S.J. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst. Rev. 2013, 1, doi:10.1002/14651858.CD000262.pub4.
    • (2013) Cochrane Database Syst. Rev , vol.1
    • Brocklehurst, P.1    Gordon, A.2    Heatley, E.3    Milan, S.J.4
  • 31
    • 12244295449 scopus 로고    scopus 로고
    • Should asymptomatic bacteriuria be screened in pregnancy?
    • Uncu, Y.; Uncu, G.; Esmer, A.; Bilgel, N. Should asymptomatic bacteriuria be screened in pregnancy? Clin. Exp. Obstet. Gynecol. 2002, 29, 281-285.
    • (2002) Clin. Exp. Obstet. Gynecol , vol.29 , pp. 281-285
    • Uncu, Y.1    Uncu, G.2    Esmer, A.3    Bilgel, N.4
  • 34
    • 15944393187 scopus 로고    scopus 로고
    • Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: A systematic review
    • Okun, N.; Gronau, K.A.; Hannah, M.E. Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: A systematic review. Obstet. Gynecol. 2005, 105, 857-868.
    • (2005) Obstet. Gynecol , vol.105 , pp. 857-868
    • Okun, N.1    Gronau, K.A.2    Hannah, M.E.3
  • 35
    • 84887895722 scopus 로고    scopus 로고
    • Infection and antibiotics in the aetiology, prediction and prevention of preterm birth
    • Oliver, R.S.; Lamont, R.F. Infection and antibiotics in the aetiology, prediction and prevention of preterm birth. J. Obstet. Gynaecol. 2013, 33, 768-775.
    • (2013) J. Obstet. Gynaecol , vol.33 , pp. 768-775
    • Oliver, R.S.1    Lamont, R.F.2
  • 37
    • 0037999040 scopus 로고    scopus 로고
    • National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes
    • Mercer, B.M.; Goldenberg, R.L.; Das, A.F.; Thurnau, G.R.; Bendon, R.W.; Miodovnik, M.; Ramsey, R.D.; Rabello, Y.A.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes. Semin. Perinatol. 2003, 27, 217-230.
    • (2003) Semin. Perinatol , vol.27 , pp. 217-230
    • Mercer, B.M.1    Goldenberg, R.L.2    Das, A.F.3    Thurnau, G.R.4    Bendon, R.W.5    Miodovnik, M.6    Ramsey, R.D.7    Rabello, Y.A.8
  • 38
    • 0029985124 scopus 로고    scopus 로고
    • Neonatal early onset group B streptococcal infection. A nine-year retrospective study in a tertiary care hospital
    • Adriaanse, A.H.; Lagendijk, I.; Muytjens, H.L.; Nijhuis, J.G.; Kollee, L.-A. Neonatal early onset group B streptococcal infection. A nine-year retrospective study in a tertiary care hospital. J. Perinat. Med. 1996, 24, 531-538.
    • (1996) J. Perinat. Med , vol.24 , pp. 531-538
    • Adriaanse, A.H.1    Lagendijk, I.2    Muytjens, H.L.3    Nijhuis, J.G.4    Kollee, L.-A.5
  • 40
    • 0034755850 scopus 로고    scopus 로고
    • Early-onset neonatal sepsis in the era of group B streptococcal prevention
    • Baltimore, R.S.; Huie, S.M.; Meek, J.I.; Schuchat, A.; O'Brien, K.L. Early-onset neonatal sepsis in the era of group B streptococcal prevention. Pediatrics 2001, 108, 1094-1098.
    • (2001) Pediatrics , vol.108 , pp. 1094-1098
    • Baltimore, R.S.1    Huie, S.M.2    Meek, J.I.3    Schuchat, A.4    O'Brien, K.L.5
  • 42
    • 84861532134 scopus 로고    scopus 로고
    • Clinical sepsis in neonates and young infants, United States, 1988-2006
    • Lukacs, S.L.; Schrag, S.J. Clinical sepsis in neonates and young infants, United States, 1988-2006. J. Pediatr. 2012, 160, 960-965.
    • (2012) J. Pediatr , vol.160 , pp. 960-965
    • Lukacs, S.L.1    Schrag, S.J.2
  • 44
    • 0022922663 scopus 로고
    • The carrier state: Group B streptococcus
    • Easmon, C.S. The carrier state: Group B streptococcus. J. Antimicrob. Chemother. 1986, 18, S59-S65.
    • (1986) J. Antimicrob. Chemother , vol.18
    • Easmon, C.S.1
  • 45
    • 67651124647 scopus 로고    scopus 로고
    • Diagnostic accuracy of a rapid real-time polymerase chain reaction assay for universal intrapartum group B streptococcus screening
    • El Helali, N.; Nguyen, J.C.; Ly, A.; Giovangrandi, Y.; Trinquart, L. Diagnostic accuracy of a rapid real-time polymerase chain reaction assay for universal intrapartum group B streptococcus screening. Clin. Infect. Dis. 2009, 49, 417-423.
    • (2009) Clin. Infect. Dis , vol.49 , pp. 417-423
    • El Helali, N.1    Nguyen, J.C.2    Ly, A.3    Giovangrandi, Y.4    Trinquart, L.5
  • 46
    • 0036709933 scopus 로고    scopus 로고
    • Intrapartum antibiotic prophylaxis 2: Positive predictive value of antenatal group B streptococci cultures and antibiotic susceptibility of clinical isolates
    • Edwards, R.K.; Clark, P.; Duff, P. Intrapartum antibiotic prophylaxis 2: Positive predictive value of antenatal group B streptococci cultures and antibiotic susceptibility of clinical isolates. Obstet. Gynecol. 2002, 100, 540-544.
    • (2002) Obstet. Gynecol , vol.100 , pp. 540-544
    • Edwards, R.K.1    Clark, P.2    Duff, P.3
  • 47
    • 0034935024 scopus 로고    scopus 로고
    • Choosing a strategy to prevent neonatal early-onset group B streptococcal sepsis: Economic evaluation
    • Stan, C.M.; Boulvain, M.; Bovier, P.A.; Auckenthaler, R.; Berner, M.; Irion, O. Choosing a strategy to prevent neonatal early-onset group B streptococcal sepsis: Economic evaluation. BJOG 2001, 108, 840-847.
    • (2001) BJOG , vol.108 , pp. 840-847
    • Stan, C.M.1    Boulvain, M.2    Bovier, P.A.3    Auckenthaler, R.4    Berner, M.5    Irion, O.6
  • 48
    • 77958147117 scopus 로고    scopus 로고
    • The accuracy of late third-trimester antenatal screening for group B streptococcus in predicting colonization at delivery
    • Towers, C.V.; Rumney, P.J.; Asrat, T.; Preslicka, C.; Ghamsary, M.G.; Nageotte, M.P. The accuracy of late third-trimester antenatal screening for group B streptococcus in predicting colonization at delivery. Amer. J. Perinatol. 2010, 27, 785-790.
    • (2010) Amer. J. Perinatol , vol.27 , pp. 785-790
    • Towers, C.V.1    Rumney, P.J.2    Asrat, T.3    Preslicka, C.4    Ghamsary, M.G.5    Nageotte, M.P.6
  • 49
    • 25144465574 scopus 로고    scopus 로고
    • Early-onset group B streptococcal disease in the era of maternal screening
    • Puopolo, K.M.; Madoff, L.C.; Eichenwald, E.C. Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics 2005, 115, 1240-1246.
    • (2005) Pediatrics , vol.115 , pp. 1240-1246
    • Puopolo, K.M.1    Madoff, L.C.2    Eichenwald, E.C.3
  • 50
    • 84940290390 scopus 로고    scopus 로고
    • Antenatal Care. NICE Clinical Guideline, Available online: (accessed on 5 August 2014)
    • Antenatal Care. NICE Clinical Guideline. Available online: http://www.nice.org.uk/guidance/CG62 (accessed on 5 August 2014).
  • 51
    • 84940258190 scopus 로고    scopus 로고
    • The prevention of early-onset neonatal group b streptococcal disease
    • Royal College of Obstetricians and Gynaecologists
    • Royal College of Obstetricians and Gynaecologists. The prevention of early-onset neonatal group b streptococcal disease. Green-top Guidel. 2012, 36, 1-13.
    • (2012) Green-top Guidel , vol.36 , pp. 1-13
  • 55
    • 0034692557 scopus 로고    scopus 로고
    • Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
    • Wu, Y.W.; Colford, J.M., Jr. Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis. JAMA 2000, 284, 1417-1424.
    • (2000) JAMA , vol.284 , pp. 1417-1424
    • Wu, Y.W.1    Colford Jr., J.M.2
  • 56
    • 84872315496 scopus 로고    scopus 로고
    • Chorioamnionitis as a risk factor for necrotizing enterocolitis: A systematic review and meta-analysis
    • Been, J.V.; Lievense, S.; Zimmermann, L.J.; Kramer, B.W.; Wolfs, T.G. Chorioamnionitis as a risk factor for necrotizing enterocolitis: A systematic review and meta-analysis. J. Pediatr. 2013, 162, 236-242.
    • (2013) J. Pediatr , vol.162 , pp. 236-242
    • Been, J.V.1    Lievense, S.2    Zimmermann, L.J.3    Kramer, B.W.4    Wolfs, T.G.5
  • 57
    • 0024157149 scopus 로고
    • A randomized trial of intrapartum vs. immediate postpartum treatment of women with intra-amniotic infection
    • Gibbs, R.S.; Dinsmoor, M.J.; Newton, E.R.; Ramamurthy, R.S. A randomized trial of intrapartum vs. immediate postpartum treatment of women with intra-amniotic infection. Obstet. Gynecol. 1988, 72, 823-828.
    • (1988) Obstet. Gynecol , vol.72 , pp. 823-828
    • Gibbs, R.S.1    Dinsmoor, M.J.2    Newton, E.R.3    Ramamurthy, R.S.4
  • 58
    • 0023470621 scopus 로고
    • A comparison of intrapartum vs. immediate postpartum treatment of intra-amniotic infection
    • Sperling, R.S.; Ramamurthy, R.S.; Gibbs, R.S. A comparison of intrapartum vs. immediate postpartum treatment of intra-amniotic infection. Obstet. Gynecol. 1987, 70, 861-865.
    • (1987) Obstet. Gynecol , vol.70 , pp. 861-865
    • Sperling, R.S.1    Ramamurthy, R.S.2    Gibbs, R.S.3
  • 59
    • 0023835548 scopus 로고
    • Maternal morbidity following cesarean section: Effect of infection control and preventive use of antibiotics
    • Hirsch, H.A.; Niehues, U. Maternal morbidity following cesarean section: Effect of infection control and preventive use of antibiotics. Geburtshilfe Frauenheilkd. 1988, 48, 1-7.
    • (1988) Geburtshilfe Frauenheilkd , vol.48 , pp. 1-7
    • Hirsch, H.A.1    Niehues, U.2
  • 61
    • 0021032192 scopus 로고
    • The use of prophylactic antibiotics in patients undergoing emergency primary cesarean section
    • Wallace, R.L.; Yonekura, M.L. The use of prophylactic antibiotics in patients undergoing emergency primary cesarean section. Amer. J. Obstet. Gynecol. 1983, 147, 533-536.
    • (1983) Amer. J. Obstet. Gynecol , vol.147 , pp. 533-536
    • Wallace, R.L.1    Yonekura, M.L.2
  • 62
    • 0020059570 scopus 로고
    • Prophylactic antibiotics for cesarean section: Comparison of high-and low-risk patients for endomyometritis
    • Apuzzio, J.J.; Reyelt, C.; Pelosi, M.; Sen, P.; Louria, D.B. Prophylactic antibiotics for cesarean section: Comparison of high-and low-risk patients for endomyometritis. Obstet. Gynecol. 1982, 59, 693-698.
    • (1982) Obstet. Gynecol , vol.59 , pp. 693-698
    • Apuzzio, J.J.1    Reyelt, C.2    Pelosi, M.3    Sen, P.4    Louria, D.B.5
  • 63
    • 8544284810 scopus 로고    scopus 로고
    • Prophylactic antibiotics for non-laboring patients with intact membranes undergoing cesarean delivery: An economic analysis
    • Chelmow, D.; Hennesy, M.; Evantash, E.G. Prophylactic antibiotics for non-laboring patients with intact membranes undergoing cesarean delivery: An economic analysis. Amer. J. Obstet. Gynecol. 2004, 191, 1661-1665.
    • (2004) Amer. J. Obstet. Gynecol , vol.191 , pp. 1661-1665
    • Chelmow, D.1    Hennesy, M.2    Evantash, E.G.3
  • 64
    • 77950905671 scopus 로고    scopus 로고
    • Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section
    • doi:10.1002/14651858.CD007482.pub2
    • Smaill, F.M.; Gyte, G.M. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database Syst. Rev. 2010, doi:10.1002/14651858.CD007482.pub2.
    • (2010) Cochrane Database Syst. Rev
    • Smaill, F.M.1    Gyte, G.M.2
  • 66
    • 84871860682 scopus 로고    scopus 로고
    • Preprocedure antibiotics reduce infection after cesarean delivery
    • doi:10.1097/01.NAJ.0000422237.25309.8b
    • Rosenberg, K. Preprocedure antibiotics reduce infection after cesarean delivery. Amer. J. Nurs. 2012, 112, doi:10.1097/01.NAJ.0000422237.25309.8b.
    • (2012) Amer. J. Nurs , vol.112
    • Rosenberg, K.1
  • 67
    • 84876814243 scopus 로고    scopus 로고
    • Prophylactic administration of cefazolin prior to skin incision vs. antibiotics at cord clamping in preventing postcesarean infectious morbidity: A systematic review and meta-analysis of randomized controlled trials
    • Sun, J.; Ding, M.; Liu, J.; Li, Y.; Sun, X.; Liu, T.; Chen, Y.; Liu, J. Prophylactic administration of cefazolin prior to skin incision vs. antibiotics at cord clamping in preventing postcesarean infectious morbidity: A systematic review and meta-analysis of randomized controlled trials. Gynecol. Obstet. Investig. 2013, 75, 175-178.
    • (2013) Gynecol. Obstet. Investig , vol.75 , pp. 175-178
    • Sun, J.1    Ding, M.2    Liu, J.3    Li, Y.4    Sun, X.5    Liu, T.6    Chen, Y.7    Liu, J.8
  • 68
    • 84885018958 scopus 로고    scopus 로고
    • Timing of prophylactic antibiotic at cesarean section: A double-blinded, randomized trial
    • Francis, C.; Mumford, M.; Strand, M.L.; Moore, E.S.; Strand, E.A. Timing of prophylactic antibiotic at cesarean section: A double-blinded, randomized trial. J. Perinatol. 2013, 33, 759-762.
    • (2013) J. Perinatol , vol.33 , pp. 759-762
    • Francis, C.1    Mumford, M.2    Strand, M.L.3    Moore, E.S.4    Strand, E.A.5
  • 69
    • 84555187143 scopus 로고    scopus 로고
    • Antibiotic prophylaxis before surgery vs. after cord clamping in elective cesarean delivery: A double-blind, prospective, randomized, placebo-controlled trial
    • Witt, A.; Doner, M.; Petricevic, L.; Berger, A.; Germann, P.; Heinze, G.; Tempfer, C. Antibiotic prophylaxis before surgery vs. after cord clamping in elective cesarean delivery: A double-blind, prospective, randomized, placebo-controlled trial. Arch. Surg. 2011, 146, 1404-1409.
    • (2011) Arch. Surg , vol.146 , pp. 1404-1409
    • Witt, A.1    Doner, M.2    Petricevic, L.3    Berger, A.4    Germann, P.5    Heinze, G.6    Tempfer, C.7
  • 71
    • 84883306154 scopus 로고    scopus 로고
    • Should prophylactic antibiotics be routinely given to a mother before a cesarean birth?
    • Capitulo, K.L.; Klein, V.R.; Wright, M. Should prophylactic antibiotics be routinely given to a mother before a cesarean birth? Amer. J. Matern. Child. Nurs. 2013, 38, 266-267.
    • (2013) Amer. J. Matern. Child. Nurs , vol.38 , pp. 266-267
    • Capitulo, K.L.1    Klein, V.R.2    Wright, M.3
  • 73
    • 0032870087 scopus 로고    scopus 로고
    • Change in antibiotic resistance of group B streptococcus: Impact on intrapartum management
    • Morales, W.J.; Dickey, S.S.; Bornick, P.; Lim, D.V. Change in antibiotic resistance of group B streptococcus: Impact on intrapartum management. Amer. J. Obstet. Gynecol. 1999, 181, 310-314.
    • (1999) Amer. J. Obstet. Gynecol , vol.181 , pp. 310-314
    • Morales, W.J.1    Dickey, S.S.2    Bornick, P.3    Lim, D.V.4
  • 74
    • 1542513796 scopus 로고    scopus 로고
    • Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin
    • Heelan, J.S.; Hasenbein, M.E.; McAdam, A.J. Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin. J. Clin. Microbiol. 2004, 42, 1263-1264.
    • (2004) J. Clin. Microbiol , vol.42 , pp. 1263-1264
    • Heelan, J.S.1    Hasenbein, M.E.2    McAdam, A.J.3
  • 75
    • 84932184094 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation, hemoperitoneum, and reversible ischemic neurological deficit complicating anaphylaxis to prophylactic antibiotics during cesarean delivery: A case report and review of literature
    • Borahay, M.A.; Harirah, H.M.; Olson, G.; Kilic, G.S.; Karipcin, S.; Hankins, G.D. Disseminated intravascular coagulation, hemoperitoneum, and reversible ischemic neurological deficit complicating anaphylaxis to prophylactic antibiotics during cesarean delivery: A case report and review of literature. AJP Rep. 2011, 1, 15-20.
    • (2011) AJP Rep , vol.1 , pp. 15-20
    • Borahay, M.A.1    Harirah, H.M.2    Olson, G.3    Kilic, G.S.4    Karipcin, S.5    Hankins, G.D.6
  • 76
    • 42149153924 scopus 로고    scopus 로고
    • Antibiotic prophylaxis in cesarean section causing anaphylaxis and intrauterine fetal death
    • Sengupta, A.; Kohli, J.-K. Antibiotic prophylaxis in cesarean section causing anaphylaxis and intrauterine fetal death. J. Obstet. Gynaecol. Res. 2008, 34, 252-254.
    • (2008) J. Obstet. Gynaecol. Res , vol.34 , pp. 252-254
    • Sengupta, A.1    Kohli, J.-K.2
  • 77
    • 76749091424 scopus 로고    scopus 로고
    • Anaphylaxis in the obstetric patient: Analysis of a statewide hospital discharge database
    • Mulla, Z.D.; Ebrahim, M.S.; Gonzalez, J.L. Anaphylaxis in the obstetric patient: Analysis of a statewide hospital discharge database. Ann. Allergy Asthma Immunol. 2010, 104, 55-59.
    • (2010) Ann. Allergy Asthma Immunol , vol.104 , pp. 55-59
    • Mulla, Z.D.1    Ebrahim, M.S.2    Gonzalez, J.L.3
  • 78
    • 84872694123 scopus 로고    scopus 로고
    • Anaphylaxis in pregnancy: A rare cause of neonatal mortality
    • doi:10.1136/bcr-2012-007055
    • Berenguer, A.; Couto, A.; Brites, V.; Fernandes, R. Anaphylaxis in pregnancy: A rare cause of neonatal mortality. BMJ Case Rep. 2013, 2013, doi:10.1136/bcr-2012-007055.
    • (2013) BMJ Case Rep , vol.2013
    • Berenguer, A.1    Couto, A.2    Brites, V.3    Fernandes, R.4
  • 80
    • 78049494788 scopus 로고    scopus 로고
    • Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome
    • doi:10.1371/journal.pone.0009836
    • Jakobsson, H.E.; Jernberg, C.; Andersson, A.F.; Sjolund-Karlsson, M.; Jansson, J.K.; Engstrand, L. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS One 2010, 5, doi:10.1371/journal.pone.0009836.
    • (2010) PLoS One , vol.5
    • Jakobsson, H.E.1    Jernberg, C.2    Andersson, A.F.3    Sjolund-Karlsson, M.4    Jansson, J.K.5    Engstrand, L.6
  • 81
    • 33745500997 scopus 로고    scopus 로고
    • Could peripartum antibiotics have delayed health consequences for the infant?
    • Bedford Russell, A.R.; Murch, S.H. Could peripartum antibiotics have delayed health consequences for the infant? BJOG 2006, 113, 758-765.
    • (2006) BJOG , vol.113 , pp. 758-765
    • Bedford Russell, A.R.1    Murch, S.H.2
  • 82
    • 42949150974 scopus 로고    scopus 로고
    • Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis
    • Bizzarro, M.J.; Dembry, L.M.; Baltimore, R.S.; Gallagher, P.G. Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics 2008, 121, 689-696.
    • (2008) Pediatrics , vol.121 , pp. 689-696
    • Bizzarro, M.J.1    Dembry, L.M.2    Baltimore, R.S.3    Gallagher, P.G.4
  • 83
    • 72049089858 scopus 로고    scopus 로고
    • Silent mysteries: Epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease
    • Martino, D.J.; Prescott, S.L. Silent mysteries: Epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease. Allergy 2010, 65, 7-15.
    • (2010) Allergy , vol.65 , pp. 7-15
    • Martino, D.J.1    Prescott, S.L.2
  • 84
    • 33646482235 scopus 로고    scopus 로고
    • The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study
    • Jedrychowski, W.; Galas, A.; Whyatt, R.; Perera, F. The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study. Int. J. Occup. Med. Environ. Health 2006, 19, 70-76.
    • (2006) Int. J. Occup. Med. Environ. Health , vol.19 , pp. 70-76
    • Jedrychowski, W.1    Galas, A.2    Whyatt, R.3    Perera, F.4
  • 85
    • 79958058103 scopus 로고    scopus 로고
    • Atopic dermatitis and the hygiene hypothesis revisited
    • Flohr, C.; Yeo, L. Atopic dermatitis and the hygiene hypothesis revisited. Curr. Probl. Dermatol. 2011, 41, 1-34.
    • (2011) Curr. Probl. Dermatol , vol.41 , pp. 1-34
    • Flohr, C.1    Yeo, L.2
  • 86
    • 33644828006 scopus 로고    scopus 로고
    • Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: An effect of hygienic lifestyle?
    • Adlerberth, I.; Lindberg, E.; Aberg, N.; Hesselmar, B.; Saalman, R.; Strannegard, I.L.; Wold, A.E. Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: An effect of hygienic lifestyle? Pediatr. Res. 2006, 59, 96-101.
    • (2006) Pediatr. Res , vol.59 , pp. 96-101
    • Adlerberth, I.1    Lindberg, E.2    Aberg, N.3    Hesselmar, B.4    Saalman, R.5    Strannegard, I.L.6    Wold, A.E.7
  • 87
    • 79957883289 scopus 로고    scopus 로고
    • Prenatal or early-life exposure to antibiotics and risk of childhood asthma: A systematic review
    • Murk, W.; Risnes, K.R.; Bracken, M.B. Prenatal or early-life exposure to antibiotics and risk of childhood asthma: A systematic review. Pediatrics 2011, 127, 1125-1138.
    • (2011) Pediatrics , vol.127 , pp. 1125-1138
    • Murk, W.1    Risnes, K.R.2    Bracken, M.B.3
  • 89
    • 79251477530 scopus 로고    scopus 로고
    • Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1401 U.S. children
    • Risnes, K.R.; Belanger, K.; Murk, W.; Bracken, M.B. Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1401 U.S. children. Amer. J. Epidemiol. 2011, 173, 310-318.
    • (2011) Amer. J. Epidemiol , vol.173 , pp. 310-318
    • Risnes, K.R.1    Belanger, K.2    Murk, W.3    Bracken, M.B.4
  • 94
    • 0037310149 scopus 로고    scopus 로고
    • Hazards of widespread use of erythromycin for preterm prelabour rupture of membranes
    • doi:10.1016/S0140-6736(03)12420-8
    • Tan, S.; Holliman, R.; Russell, A.R. Hazards of widespread use of erythromycin for preterm prelabour rupture of membranes. Lancet 2003, 361, doi:10.1016/S0140-6736(03)12420-8.
    • (2003) Lancet , vol.361
    • Tan, S.1    Holliman, R.2    Russell, A.R.3
  • 95
    • 34547568707 scopus 로고    scopus 로고
    • Detection of erythromycin and clindamycin resistance genes in Group B Streptococcal clinical isolates and cervicovaginal-rectal swabs
    • Gygax, S.E.; Schuyler, J.A.; Trama, J.P.; Mordechai, E.; Adelson, M.E. Detection of erythromycin and clindamycin resistance genes in Group B Streptococcal clinical isolates and cervicovaginal-rectal swabs. Microb. Drug Resist. 2007, 13, 119-123.
    • (2007) Microb. Drug Resist , vol.13 , pp. 119-123
    • Gygax, S.E.1    Schuyler, J.A.2    Trama, J.P.3    Mordechai, E.4    Adelson, M.E.5
  • 97
    • 0031794906 scopus 로고    scopus 로고
    • Potential consequences of widespread antepartal use of ampicillin
    • Towers, C.V.; Carr, M.H.; Padilla, G.; Asrat, T. Potential consequences of widespread antepartal use of ampicillin. Amer. J. Obstet. Gynecol. 1998, 179, 879-883.
    • (1998) Amer. J. Obstet. Gynecol , vol.179 , pp. 879-883
    • Towers, C.V.1    Carr, M.H.2    Padilla, G.3    Asrat, T.4
  • 98
    • 0035080547 scopus 로고    scopus 로고
    • Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: A meta-analysis
    • Chelmow, D.; Ruehli, M.S.; Huang, E. Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: A meta-analysis. Amer. J. Obstet. Gynecol. 2001, 184, 656-661.
    • (2001) Amer. J. Obstet. Gynecol , vol.184 , pp. 656-661
    • Chelmow, D.1    Ruehli, M.S.2    Huang, E.3
  • 99
    • 0025124385 scopus 로고
    • Preventive antibiotics in emergency cesarean section. A prospective comparison of benzylpenicillin and ampicillin plus cloxacillin
    • Fredriksson, A.; Thomassen, P. Preventive antibiotics in emergency cesarean section. A prospective comparison of benzylpenicillin and ampicillin plus cloxacillin. Tidsskr. Nor. Laegeforen. 1990, 110, 348-350.
    • (1990) Tidsskr. Nor. Laegeforen , vol.110 , pp. 348-350
    • Fredriksson, A.1    Thomassen, P.2
  • 102
    • 79954949868 scopus 로고    scopus 로고
    • Intrapartum Group B streptococcus detection by rapid polymerase chain reaction assay for the prevention of neonatal sepsis
    • De Tejada, B.M.; Pfister, R.E.; Renzi, G.; Francois, P.; Irion, O.; Boulvain, M.; Schrenzel, J. Intrapartum Group B streptococcus detection by rapid polymerase chain reaction assay for the prevention of neonatal sepsis. Clin. Microbiol. Infect. 2011, 17, 1786-1791.
    • (2011) Clin. Microbiol. Infect , vol.17 , pp. 1786-1791
    • De Tejada, B.M.1    Pfister, R.E.2    Renzi, G.3    Francois, P.4    Irion, O.5    Boulvain, M.6    Schrenzel, J.7
  • 103
    • 78650358586 scopus 로고    scopus 로고
    • Intrapartum tests for group B streptococcus: Accuracy and acceptability of screening
    • Daniels, J.P.; Gray, J.; Pattison, H.M.; Gray, R.; Hills, R.K.; Khan, K.S. Intrapartum tests for group B streptococcus: Accuracy and acceptability of screening. BJOG 2011, 118, 257-265.
    • (2011) BJOG , vol.118 , pp. 257-265
    • Daniels, J.P.1    Gray, J.2    Pattison, H.M.3    Gray, R.4    Hills, R.K.5    Khan, K.S.6
  • 104
    • 4644315386 scopus 로고    scopus 로고
    • Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus colonization in pregnant women
    • Davies, H.D.; Miller, M.A.; Faro, S.; Gregson, D.; Kehl, S.C.; Jordan, J.A. Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus colonization in pregnant women. Clin. Infect. Dis. 2004, 39, 1129-1135.
    • (2004) Clin. Infect. Dis , vol.39 , pp. 1129-1135
    • Davies, H.D.1    Miller, M.A.2    Faro, S.3    Gregson, D.4    Kehl, S.C.5    Jordan, J.A.6
  • 105
    • 34648816811 scopus 로고    scopus 로고
    • A comparison of a new rapid real-time polymerase chain reaction system to traditional culture in determining group B streptococcus colonization
    • Gavino, M.; Wang, E. A comparison of a new rapid real-time polymerase chain reaction system to traditional culture in determining group B streptococcus colonization. Amer. J. Obstet. Gynecol. 2007, 197, 1-4.
    • (2007) Amer. J. Obstet. Gynecol , vol.197 , pp. 1-4
    • Gavino, M.1    Wang, E.2
  • 106
    • 84859032345 scopus 로고    scopus 로고
    • Cost and effectiveness of intrapartum group B streptococcus polymerase chain reaction screening for term deliveries
    • El Helali, N.; Giovangrandi, Y.; Guyot, K.; Chevet, K.; Gutmann, L.; Durand-Zaleski, I. Cost and effectiveness of intrapartum group B streptococcus polymerase chain reaction screening for term deliveries. Obstet. Gynecol. 2012, 119, 822-829.
    • (2012) Obstet. Gynecol , vol.119 , pp. 822-829
    • El Helali, N.1    Giovangrandi, Y.2    Guyot, K.3    Chevet, K.4    Gutmann, L.5    Durand-Zaleski, I.6
  • 107
    • 0035746490 scopus 로고    scopus 로고
    • ORACLE-Antibiotics for preterm prelabour rupture of the membranes: Short-term and long-term outcomes
    • Kenyon, S.; Taylor, D.J.; Tarnow-Mordi, W.O. ORACLE-Antibiotics for preterm prelabour rupture of the membranes: Short-term and long-term outcomes. Acta Paediatr. Suppl. 2002, 91, 12-15.
    • (2002) Acta Paediatr. Suppl , vol.91 , pp. 12-15
    • Kenyon, S.1    Taylor, D.J.2    Tarnow-Mordi, W.O.3
  • 109
    • 33646799120 scopus 로고    scopus 로고
    • ACOG Practice Bulletin. Vaginitis
    • ACOG Practice Bulletin. Vaginitis. Obstet. Gynecol. 2006, 107, 1195-1206.
    • (2006) Obstet. Gynecol , vol.107 , pp. 1195-1206
  • 110
    • 0031454303 scopus 로고    scopus 로고
    • Vaginitis
    • Sobel, J.D. Vaginitis. N. Engl. J. Med. 1997, 337, 1896-1903.
    • (1997) N. Engl. J. Med , vol.337 , pp. 1896-1903
    • Sobel, J.D.1
  • 111
    • 27944450150 scopus 로고    scopus 로고
    • Advances in diagnosing vaginitis: Development of a new algorithm
    • Nyirjesy, P.; Sobel, J.D. Advances in diagnosing vaginitis: Development of a new algorithm. Curr. Infect. Dis. Rep. 2005, 7, 458-462.
    • (2005) Curr. Infect. Dis. Rep , vol.7 , pp. 458-462
    • Nyirjesy, P.1    Sobel, J.D.2
  • 113
    • 77953510768 scopus 로고    scopus 로고
    • Diagnosis and management of clinical chorioamnionitis
    • Tita, A.T.; Andrews, W.W. Diagnosis and management of clinical chorioamnionitis. Clin. Perinatol. 2010, 37, 339-354.
    • (2010) Clin. Perinatol , vol.37 , pp. 339-354
    • Tita, A.T.1    Andrews, W.W.2
  • 114
    • 0033808636 scopus 로고    scopus 로고
    • Association between epidural analgesia and intrapartum fever
    • Gonen, R.; Korobochka, R.; Degani, S.; Gaitini, L. Association between epidural analgesia and intrapartum fever. Amer. J. Perinatol. 2000, 17, 127-130.
    • (2000) Amer. J. Perinatol , vol.17 , pp. 127-130
    • Gonen, R.1    Korobochka, R.2    Degani, S.3    Gaitini, L.4
  • 115
    • 33750287271 scopus 로고    scopus 로고
    • Risk factors for maternal intrapartum fever and short-term neonatal outcome
    • Maayan-Metzger, A.; Mazkereth, R.; Shani, A.; Kuint, J. Risk factors for maternal intrapartum fever and short-term neonatal outcome. Fetal Pediatr. Pathol. 2006, 25, 169-177.
    • (2006) Fetal Pediatr. Pathol , vol.25 , pp. 169-177
    • Maayan-Metzger, A.1    Mazkereth, R.2    Shani, A.3    Kuint, J.4
  • 117
    • 0023243013 scopus 로고
    • Short course of antibiotics for post-cesarean section endometritis
    • Cabbad, M.; Sijin, O.; Minkoff, H. Short course of antibiotics for post-cesarean section endometritis. Amer. J. Obstet. Gynecol. 1987, 157, 908-909.
    • (1987) Amer. J. Obstet. Gynecol , vol.157 , pp. 908-909
    • Cabbad, M.1    Sijin, O.2    Minkoff, H.3
  • 118
    • 0242543058 scopus 로고    scopus 로고
    • Single additional dose postpartum therapy for women with chorioamnionitis
    • Edwards, R.K.; Duff, P. Single additional dose postpartum therapy for women with chorioamnionitis. Obstet. Gynecol. 2003, 102, 957-961.
    • (2003) Obstet. Gynecol , vol.102 , pp. 957-961
    • Edwards, R.K.1    Duff, P.2
  • 119
    • 0030666343 scopus 로고    scopus 로고
    • Randomized trial of single-dose vs. multiple-dose cefotetan for the postpartum treatment of intrapartum chorioamnionitis
    • Chapman, S.J.; Owen, J. Randomized trial of single-dose vs. multiple-dose cefotetan for the postpartum treatment of intrapartum chorioamnionitis. Amer. J. Obstet. Gynecol. 1997, 177, 831-834.
    • (1997) Amer. J. Obstet. Gynecol , vol.177 , pp. 831-834
    • Chapman, S.J.1    Owen, J.2


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