Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children

American Journal of Epidemiology

Volumn 173, Issue 3, 2011, Pages 310-318

  Risnes, Kari R ^a,b,c   Belanger, Kathleen ^a   Murk, William ^a   Bracken, Michael B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

anti bacterial agents; asthma; child; cohort studies; hypersensitivity

Indexed keywords

ANTIBIOTIC AGENT;

ALLERGY; ANTIBIOTICS; ASTHMA; CHILD HEALTH; RISK FACTOR;

AGE; ANTIBIOTIC THERAPY; ARTICLE; ASTHMA; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EXPOSURE; DRUG USE; FAMILY HISTORY; FEMALE; HUMAN; INFANT; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; RESPIRATORY TRACT ALLERGY; RISK; SKIN TEST; STATISTICAL ANALYSIS; UNITED STATES;

ADULT; ANTI-BACTERIAL AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMORBIDITY; FEMALE; HUMANS; HYPERSENSITIVITY; INFANT; INFANT, NEWBORN; INTERVIEWS AS TOPIC; LOGISTIC MODELS; MALE; NEW ENGLAND; PREGNANCY; RISK FACTORS; SKIN TESTS; UNITED STATES; YOUNG ADULT;

UNITED STATES;

BACTERIA (MICROORGANISMS);

EID: 79251477530     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwq400     Document Type: Article

References (42)

1. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med. 2006;355(21):2226-2235.
2. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299(6710):1259-1260.
3. Schaub B, Lauener R, von Mutius E. The many faces of the hygiene hypothesis. J Allergy Clin Immunol. 2006;117(5): 969-977, quiz 978.
4. Holt PG, van den Biggelaar AH. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the role of infections in allergy: atopic asthma as a paradigm. Clin Exp Immunol. 2010;160(1):22-26.
5. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet. 1999;354(suppl 2):SII12-SII15.
6. Nyquist AC, Gonzales R, Steiner JF, et al. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA. 1998;279(11):875-877. (Pubitemid 28185554)
7. Cohet C, Cheng S, MacDonald C, et al. Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood. J Epidemiol Community Health. 2004;58(10):852-857.
8. Ahn KM, Lee MS, Hong SJ, et al. Fever, use of antibiotics, and acute gastroenteritis during infancy as risk factors for the development of asthma in Korean school-age children. J Asthma. 2005;42(9):745-750.
9. McKeever TM, Lewis SA, Smith C, et al. Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database. J Allergy Clin Immunol. 2002;109(1):43-50.
10. Kozyrskyj AL, Ernst P, Becker AB. Increased risk of childhood asthma from antibiotic use in early life. Chest. 2007;131(6):1753-1759.
11. Martel MJ, Rey E, Malo JL, et al. Determinants of the incidence of childhood asthma: a two-stage case-control study. Am J Epidemiol. 2009;169(2):195-205.
12. Marra F, Marra CA, Richardson K, et al. Antibiotic use in children is associated with increased risk of asthma. Pediatrics. 2009;123(3):1003-1010.
13. Mai XM, Kull I, Wickman M, et al. Antibiotic use in early life and development of allergic diseases: respiratory infection as the explanation. Clin Exp Allergy. 2010;40(8):1230-1237.
14. Marra F, Lynd L, Coombes M, et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis. Chest. 2006;129(3):610-618.
15. Celedón JC, Litonjua AA, Ryan L, et al. Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years. Am J Respir Crit Care Med. 2002;166(1):72-75.
16. Kusel MM, de Klerk N, Holt PG, et al. Antibiotic use in the first year of life and risk of atopic disease in early childhood. Clin Exp Allergy. 2008;38(12):1921-1928.
17. Kang EM, Lundsberg LS, Illuzzi JL, et al. Prenatal exposure to acetaminophen and asthma in children. Obstet Gynecol. 2009; 114(6):1295-1306.
18. Bracken MB, Triche EW, Belanger K, et al. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstet Gynecol. 2003;102(4):739-752.
19. Belanger K, Hellenbrand ME, Holford TR, et al. Effect of pregnancy on maternal asthma symptoms and medication use. Obstet Gynecol. 2010;115(3):559-567.
20. Salas M, Hofman A, Stricker BH. Confounding by indication: an example of variation in the use of epidemiologic terminology. Am J Epidemiol. 1999;149(11):981-983.
21. Tamim H, Monfared AA, LeLorier J. Application of lag-time into exposure definitions to control for protopathic bias. Pharmacoepidemiol Drug Saf. 2007;16(3):250-258.
22. Celedón JC, Fuhlbrigge A, Rifas-Shiman S, et al. Antibiotic use in the first year of life and asthma in early childhood. Clin Exp Allergy. 2004;34(7):1011-1016.
23. Harlow SD, Linet MS. Agreement between questionnaire data and medical records. The evidence for accuracy of recall. Am J Epidemiol. 1989;129(2):233-248.
24. Pless CE, Pless IB. How well they remember. The accuracy of parent reports. Arch Pediatr Adolesc Med. 1995;149(5):553-538.
25. Nicholas C, Wegienka G, Havstad S, et al. How accurately do young adults recall childhood pets? A validation study. Am J Epidemiol. 2009;170(3):388-392.
26. Kjellman NI, Croner S, Gustafsson PM. Development of asthma in children. Allerg Immunol (Paris). 1991;23(8):351-357.
27. Øien T, Storrø O, Johnsen R. Assessing atopic disease in children two to six years old: reliability of a revised questionnaire. Prim Care Respir J. 2008;17(3):164-168.
28. Droste JH, Wieringa MH, Weyler JJ, et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy. 2000;30(11):1547-1553.
29. Platts-Mills TA, Woodfolk JA, Sporik RB. Con: the increase in asthma cannot be ascribed to cleanliness. Am J Respir Crit Care Med. 2001;164(7):1107-1108, discussion 1108-1109.
30. Björkstén B. The hygiene hypothesis: do we still believe in it? Nestle Nutr Workshop Ser Pediatr Program. 2009;64:11-18, discussion 18-22.
31. von Mutius E. Pro: the increase in asthma can be ascribed to cleanliness. Am J Respir Crit Care Med. 2001;164(7): 1106-1107, discussion 1108-1109.
32. Ribeiro-do-Couto LM, Boeije LC, Kroon JS, et al. High IL-13 production by human neonatal T cells: neonate immune system regulator? Eur J Immunol. 2001;31(11):3394-3402.
33. Prescott SL. Early origins of allergic disease: a review of processes and influences during early immune development. Curr Opin Allergy Clin Immunol. 2003;3(2):125-132.
34. von Mutius E. Allergies, infections and the hygiene hypothesis- the epidemiological evidence. Immunobiology. 2007;212(6): 433-439.
35. Holt PG, Clough JB, Holt BJ, et al. Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence. Clin Exp Allergy. 1992;22(12):1093-1099.
36. Prescott SL, Macaubas C, Smallacombe T, et al. Development of allergen-specific T-cell memory in atopic and normal children. Lancet. 1999;353(9148):196-200.
37. Stille CJ, Andrade SE, Huang SS, et al. Increased use of second-generation macrolide antibiotics for children in nine health plans in the United States. Pediatrics. 2004;114(5): 1206-1211.
38. Illi S, von Mutius E, Lau S, et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ. 2001;322(7283):390-395. (Pubitemid 32193268)
39. von Mutius E, Illi S, Hirsch T, et al. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur Respir J. 1999;14(1):4-11.
40. Akdis CA, Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol. 2009;123(4):735-746, quiz 747-748.
41. Stevenson MD, Sellins S, Grube E, et al. Aeroallergen sensi-tization in healthy children: racial and socioeconomic correlates. J Pediatr. 2007;151(2):187-191.
42. Hamilton RG. Clinical laboratory assessment of immediate-type hypersensitivity. J Allergy Clin Immunol. 2010;125(2 suppl. 2):S284-S296.