Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia

World Journal of Biological Psychiatry

Volumn 15, Issue 7, 2014, Pages 525-533

  Choi, Soo Hee ^a   Lee, Hyeongrae ^b   Ku, Jeonghun ^b,c   Yoon, Kang Joon ^d   Kim, Jae Jin ^b  

^a Seoul National University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Keimyung University   (South Korea)

^d Kangnam St Mary's Hospital   (South Korea)

Author keywords

Anhedonia; Anterior cingulate cortex; Anticipatory pleasure; Caudate; Schizophrenia

Indexed keywords

ADULT; ANHEDONIA; ANTERIOR CINGULATE; ARTICLE; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; PERSONAL EXPERIENCE; SCHIZOPHRENIA; ANTICIPATION; CINGULATE GYRUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; YOUNG ADULT;

ADULT; ANHEDONIA; ANTICIPATION, PSYCHOLOGICAL; CAUDATE NUCLEUS; FEMALE; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PREFRONTAL CORTEX; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84907259093     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2013.819121     Document Type: Article

References (42)

1. Aghevli MA, Blanchard JJ, Horan WP. 2003. The expression and experience of emotion in schizophrenia: A study of social interactions. Psychiatry Res 119: 261-270.
2. Barch DM, Dowd EC. 2010. Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions. Schizophr Bull 36: 919-934.
3. Berridge KC, Robinson TE. 2003. Parsing reward. Trends Neurosci 26: 507-513.
4. Blanchard JJ, Mueser KT, Bellack AS. 1998. Anhedonia, positive and negative affect, and social functioning in schizophrenia. Schizophr Bull 24: 413-424.
5. Chapman LJ, Chapman JP, Raulin ML. 1976. Scales for physical and social anhedonia. J Abn Psychol 85: 374-382.
6. Cox RW. 1996. AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29: 162-173.
7. Crespo-Facorro B, Paradiso S, Andreasen NC, OLeary DS, Watkins GL, Ponto LL, et al. 2001. Neural mechanisms of anhedonia in schizophrenia: A PET study of response to unpleasant and pleasant odors. J Am Med Assoc 286: 427-435.
8. Dowd EC, Barch DM. 2010. Anhedonia and emotional experience in schizophrenia: Neural and behavioral indicators. Biol Psychiatry 67: 902-911.
9. Dowd EC, Barch DM. 2012. Pavlovian reward prediction and receipt in schizophrenia: Relationship to anhedonia. PLoS One 7: E35622.
10. First MB, Gibbon M, Spitzer RL, Williams JBW. 2002. Users Guide for the Structured Clinical Interview for DMS-IV-TR AxisíDisorders-Research Version (SCID-I for DSM-IV-TR). New York: New York State Psychiatric Institute.
11. Gard DE, Kring AM, Gard MG, Horan WP, Green MF. 2007. Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure. Schizophr Res 93: 253-260.
12. Gilbert SJ, Spengler S, Simons JS, Steele JD, Lawrie SM, Frith CD, et al. 2006. Functional specialization within rostral prefrontal cortex (area 10): A meta-Analysis. J Cogn Neurosci 18: 932-948.
13. Haruno M, Kuroda T, Doya K, Toyama K, Kimura M, Samejima K, et al. 2004. A neural correlate of reward-based behavioral learning in caudate nucleus: A functional magnetic resonance imaging study of a stochastic decision task. J Neurosci 24: 1660-1665.
14. Harvey P, Armony J, Malla A, Lepage M. 2010. Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia. J Psychiatr Res 44: 707-716.
15. Haut KM, Lim KO, MacDonald A. 2010. Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: Effects of practice, generalization, and specifi city. Neuropsychopharmacol 35: 1850-1859.
16. Hempel A, Hempel E, Schnknecht P, Stippich C, Schrder J. 2003. Impairment in basal limbic function in schizophrenia during affect recognition. Psychiatry Res 122: 115-124.
17. Herbener ES, Harrow M, Hill SK. 2005. Change in the relationship between anhedonia and functional Deficits over a 20-year period in individuals with schizophrenia. Schizophr Res 75: 97-105.
18. Horan WP, Green MF, Kring AM, Nuechterlein KH. 2006. Does anhedonia in schizophrenia refl ect faulty memory for subjectively experienced emotions? J Abn Psychol 115: 496-508.
19. Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE. Prigatano GP. 2002. Neural correlates of self-refl ection. Brain 125: 1808-1814.
20. Juckel G, Schlagenhauf F, Koslowski M, Wüstenberg T, Villringer A, Knutson B, et al. 2006. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 29: 409-416.
21. Kawagoe R, Takikawa Y, Hikosaka O. 2004. Reward-predicting activity of dopamine and caudate neurons-A possible mechanism of motivational control of saccadic eye movement. J Neurophysiol 91: 1013-1024.
22. Kay SR, Fiszbein A, Opler LA. 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
23. Kirsch P, Ronshausen S, Mier D, Gallhofer B. 2007. The infl uence of antipsychotic treatment on brain reward system reactivity in schizophrenia patients. Pharmacopsychiatry 40: 196-198.
24. Kring AM, Kerr SL, Smith DA, Neale JM. 1993. Flat affect in schizophrenia does not refl ect diminished subjective experience of emotion. J Abn Psychol 102: 507-517.
25. Kring AM, Neale JM. 1996. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion? J Abn Psychol 105: 249-257.
26. Lee JS, Chun JW, Kang JI, Kang DI, Park HJ, Kim JJ. 2012. Hippocampus and nucleus accumbens activity during neutral word recognition related to trait physical anhedonia in patients with schizophrenia: An fMRI study. Psychiatry Res: Neuroim 203: 46-53.
27. Lee JS, Park HJ, Chun JW, Seok JH, Park IH, Park B, et al. 2011. Neuroanatomical correlates of trait anhedonia in patients with schizophrenia: A voxel-based morphometric study. Neurosci Lett 489: 110-114.
28. Lindgren L, Westling G, Brulin C, Lehtipalo S, Andersson M, Nyberg L. 2012. Pleasant human touch is represented in pregenual anterior cingulate cortex. Neuroimage 59: 3427-3432.
29. ODoherty JP, Deichmann R, Critchley HD, Dolan RJ. 2002. Neural responses during anticipation of a primary taste reward. Neuron 33: 815-826.
30. Park IH, Kim JJ, Chun J, Jung YC, Seok JH, Park HJ, et al. 2009. Medial prefrontal default-mode hypoactivity affecting trait physical anhedonia in schizophrenia. Psychiatry Res 171: 155-165.
31. Phan KL, Wager T, Taylor SF, Liberzon I. 2002. Functional neuroanatomy of emotion: A meta-Analysis of emotion activation studies in PET and fMRI. Neuroimage 16: 331-348.
32. Reske M, Kellermann T, Habel U, Jon Shah N, Backes V, von Wilmsdorff M, et al. 2007. Stability of emotional dysfunctions? A long-Term fMRI study in fi rst-episode schizophrenia. J Psychiatr Res 41: 918-927.
33. Rolls ET, Grabenhorst F, Parris BA. 2008. Warm pleasant feelings in the brain. Neuroimage 41: 1504-1513.
34. Schlagenhauf F, Juckel G, Koslowski M, Kahnt T, Knutson B, Dembler T, et al. 2008. Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine . Psychopharmacol 196: 673-684.
35. Schlagenhauf F, Sterzer P, Schmack K, Ballmaier M, Rapp M, Wrase J, et al. 2009. Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions. Biol Psychiatry 65: 1032-1039.
36. Simon JJ, Biller A, Walther S, Roesch-Ely D, Stippich C, Weisbrod M, et al. 2010. Neural correlates of reward processing in schizophrenia-relationship to apathy and depression. Schizophr Res 118: 154-161.
37. Taylor SF, Phan KL, Britton JC, Liberzon I. 2005. Neural response to emotional salience in schizophrenia. Neuropsychopharmacol 30: 984-995.
38. Trémeau F, Antonius D, Cacioppo JT, Ziwich R, Jalbrzikowski M, Saccente E, et al. 2009. In support of Bleuler: Objective evidence for increased affective ambivalence in schizophrenia based upon evocative testing. Schizophr Res 107: 223-231.
39. Tricomi EM, Delgado MR, Fiez JA. 2004. Modulation of caudate activity by action contingency. Neuron 41: 281-292.
40. Ursu S, Kring AM, Gard MG, Minzenberg MJ, Yoon JH, Ragland JD, et al. 2011. Prefrontal cortical Deficits and impaired cognition-emotion interactions in schizophrenia. Am J Psychiatry 168: 276-285.
41. Vogt BA. 2005. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6: 533-544.
42. Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC. 1996. A unifi ed statistical approach for determining signifi cant signals in images of cerebral activation. Hum Brain Mapp 4: 58-73.