Methylmalonic acid quantified in dried blood spots provides a precise, valid, and stable measure of functional vitamin b-12 status in healthy women

Journal of Nutrition

Volumn 144, Issue 10, 2014, Pages 1658-1663

  Schroder, Theresa H ^a   Quay, Teo A W ^a   Lamers, Yvonne ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID;

ADULT; BLOOD; CROSS-SECTIONAL STUDY; DIET RESTRICTION; DRIED BLOOD SPOT TESTING; FEMALE; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PROCEDURES; REPRODUCIBILITY; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

ADULT; CHROMATOGRAPHY, LIQUID; CROSS-SECTIONAL STUDIES; DRIED BLOOD SPOT TESTING; FASTING; FEMALE; HEALTHY VOLUNTEERS; HUMANS; LIMIT OF DETECTION; LINEAR MODELS; METHYLMALONIC ACID; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

EID: 84907257111     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.194829     Document Type: Article

References (28)

1. Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 2009;123:917-23.
2. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993;86:703-8.
3. Strand TA, Taneja S, Ueland PM, Refsum H, Bahl R, Schneede J, Sommerfelt H, Bhandari N. Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. Am J Clin Nutr 2013;97:310-7.
4. Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede J, Birks J, Ueland PM, Emmens K, Scott JM, et al. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clin Chem 2007;53:963-70.
5. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89:693S-6S.
6. Bailey RL, Carmel R, Green R, Pfeiffer CM, Cogswell ME, Osterloh JD, Sempos CT, Yetley EA. Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr 2011;94:552-61.
7. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
8. MacFarlane AJ, Greene-Finestone LS, Shi Y. Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey. Am J Clin Nutr 2011;94:1079-87.
9. Lamers Y. Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans. Curr Opin Clin Nutr Metab Care 2011;14:445-54.
10. Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr 2011;94:348S-58S.
11. Hoey L, Strain JJ, McNulty H. Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. Am J Clin Nutr 2009;89:1981S-96S.
12. Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011;94:313S-21S.
13. Guthrie R, Susi A. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 1963;32:338-43.
14. McDade TW, Williams S, Snodgrass JJ. What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography 2007;44:899-925.
15. Boerma JT, Holt E, Black R. Measurement of biomarkers in surveys in developing countries: opportunities and problems. Popul Dev Rev 2001;27:303-14.
16. Blom HJ, van Rooij A, Hogeveen M. A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2007;45:645-50.
17. Hempen C, Wanschers H, van der Sluijs Veer G. A fast liquid chromatographic tandem mass spectrometric method for the simultaneous determination of total homocysteine and methylmalonic acid. Anal Bioanal Chem 2008;391:263-70.
18. la Marca G, Malvagia S, Pasquini E, Innocenti M, Donati MA, Zammarchi E. Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry. Clin Chem 2007;53:1364-9.
19. Magera MJ, Helgeson JK, Matern D, Rinaldo P. Methylmalonic acid measured in plasma and urine by stable-isotope dilution and electrospray tandem mass spectrometry. Clin Chem 2000;46:1804-10.
20. Pedersen TL, Keyes WR, Shahab-Ferdows S, Allen LH, Newman JW. Methylmalonic acid quantification in low serum volumes by UPLC-MS/ MS. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879:1502-6.
21. Schmedes A, Brandslund I. Analysis ofmethylmalonic acid in plasma by liquid chromatography-tandem mass spectrometry. Clin Chem 2006;52:754-7.
22. Shigematsu Y, Hata I, Tajima G. Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria. J Inherit Metab Dis 2010;33:S283-8.
23. Turgeon CT, Magera MJ, Cuthbert CD, Loken PR, Gavrilov DK, Tortorelli S, Raymond KM, Oglesbee D, Rinaldo P, Matern D. Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. Clin Chem 2010;56:1686-95.
24. Windelberg A, Arseth O, Kvalheim G, Ueland PM. Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 2005;51:2103-9.
25. Bailey RL, Durazo-Arvizu RA, Carmel R, Green R, Pfeiffer CM, Sempos CT, Carriquiry A, Yetley EA. Modeling a methylmalonic acidderived change point for serum vitamin B-12 for adults in NHANES. Am J Clin Nutr 2013;98:460-7.
26. Chowdhury S, Banerjee R. Thermodynamic and kinetic characterization of Co2C bond homolysis catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase. Biochemistry 2000;39: 7998-8006.
27. Fenton WA, Hack AM, Willard HF, Gertler A, Rosenberg LE. Purification and properties of methylmalonyl coenzyme A mutase from human liver. Arch Biochem Biophys 1982;214: 815-23.
28. McCann MT, Thompson MM, Gueron IC, Lemieux B, Giguere R, Tuchman M. Methylmalonic acid quantification by stable isotope dilution gas chromatography-mass spectrometry from filter paper urine samples. Clin Chem 1996;42:910-4.