First enzymatic galactosylation of acyclic nucleoside drugs by β-galactosidase: Synthesis of water-soluble β-D-galactosidic prodrugs

Biotechnology and Bioprocess Engineering

Volumn 19, Issue 4, 2014, Pages 586-591

  Yan, Li Qiang ^a   Li, Ning ^a   Zong, Min Hua ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

acyclic nucleosides; enzyme substrate recognition; glycosylation; prodrugs; galactosidase

Indexed keywords

AIR CUSHION VEHICLES; ANTIVIRAL AGENTS; BIOCHEMISTRY; BIOMOLECULES; ENZYMES; GLYCOSYLATION; MAMMALS; MOLAR RATIO; SUBSTRATES; VIRUSES;

ACYCLIC NUCLEOSIDES; ENZYMATIC SYNTHESIS; ENZYME SUBSTRATES; GALACTOSIDASES; NUCLEOSIDE ANALOGS; ORAL BIOAVAILABILITIES; PRODRUGS; TRANSGALACTOSYLATION;

DRUG DELIVERY;

GALACTOSIDE; I2 DEXTRO GALACTOSIDIC PRODRUG; I2 GALACTOSIDASE; NUCLEOSIDE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY;

EID: 84907245432     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-013-0823-1     Document Type: Article

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