ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation

Free Radical Biology and Medicine

Volumn 76, Issue , 2014, Pages 147-162

  Kotla, Sivareddy ^a   Singh, Nikhlesh K ^a   Traylor, James G ^b   Wayne Orr, A ^b   Rao, Gadiparthi N ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

CD36; Foam cell; ROS; STAT1; Syk

Indexed keywords

CD36 ANTIGEN; FOCAL ADHESION KINASE 2; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYICOSATETRAENOIC ACID; INTERLEUKIN 17; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN KINASE SYK; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT1 PROTEIN; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; STAT6 PROTEIN; TRIACYLGLYCEROL; XANTHINE OXIDASE; 12-15-LIPOXYGENASE; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; APOLIPOPROTEIN E; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; LIPID; MESSENGER RNA; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BINDING SITE; CELL SURFACE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FOAM CELL; HUMAN; HUMAN TISSUE; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; ANIMAL; CELL CULTURE; CHEMISTRY; CHROMATIN IMMUNOPRECIPITATION; CORONARY ARTERY DISEASE; CYTOLOGY; DRUG EFFECTS; GEL MOBILITY SHIFT ASSAY; GENETICS; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD36; APOLIPOPROTEINS E; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CORONARY ARTERY DISEASE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FOAM CELLS; FOCAL ADHESION KINASE 2; HYDROXYEICOSATETRAENOIC ACIDS; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, KNOCKOUT; NADPH OXIDASE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 84907224934     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.08.007     Document Type: Article

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