Effects of low-dose estrogen replacement during childhood on pubertal development and gonadotropin concentrations in patients with turner syndrome: Results of a randomized, double-blind, placebo-controlled clinical trial

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 9, 2014, Pages E1754-E1764

  Quigley, Charmian A ^a   Wan, Xiaohai ^b   Garg, Sipi ^c   Kowal, Karen ^d   Cutler, Gordon B ^e   Ross, Judith L ^d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c GCE Solutions Inc   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e Gordon Cutler Consultancy   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ETHINYLESTRADIOL; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; PLACEBO;

ARTICLE; BODY HEIGHT; BONE AGE; BREAST DEVELOPMENT; CHILD; CHROMOSOME MOSAICISM; CLINICAL ASSESSMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; EARLY CHILDHOOD INTERVENTION; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; HUMAN; INTERVENTION STUDY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MENARCHE; MENSTRUATION; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PUBERTY; RANDOMIZED CONTROLLED TRIAL; TURNER SYNDROME; UNITED STATES; VAGINA BLEEDING; ADOLESCENT; BLOOD; BREAST; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HORMONE SUBSTITUTION; KAPLAN MEIER METHOD; PATHOPHYSIOLOGY; PROCEDURES; SECRETION (PROCESS); TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; BODY HEIGHT; BREAST; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GONADOTROPINS; HORMONE REPLACEMENT THERAPY; HUMANS; KAPLAN-MEIER ESTIMATE; MENARCHE; PLACEBOS; PUBERTY; TREATMENT OUTCOME; TURNER SYNDROME; YOUNG ADULT;

EID: 84907219508     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4518     Document Type: Article

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