메뉴 건너뛰기




Volumn 5, Issue 5, 2014, Pages 190-200

Adverse effects of testosterone replacement therapy: An update on the evidence and controversy

Author keywords

adverse effects; cardiovascular risk; mortality; prostate specific antigen; testosterone

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE;

EID: 84907212881     PISSN: 20420986     EISSN: 20420994     Source Type: Journal    
DOI: 10.1177/2042098614548680     Document Type: Review
Times cited : (75)

References (46)
  • 1
    • 84856200634 scopus 로고    scopus 로고
    • Prostate cancer screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up
    • Andriole G. Crawford E. Grubb III R. Buys S. Chia D. Church T. (2012) Prostate cancer screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst 104: 125–132.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 125-132
    • Andriole, G.1    Crawford, E.2    Grubb, R.3    Buys, S.4    Chia, D.5    Church, T.6
  • 4
    • 47549089695 scopus 로고    scopus 로고
    • The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing
    • Barrett-Connor E. Dam T. Stone K. Harrison S. Redline S. Orwoll E. (2008) The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing. J Clin Endocrinol Metab 93: 2602–2609.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2602-2609
    • Barrett-Connor, E.1    Dam, T.2    Stone, K.3    Harrison, S.4    Redline, S.5    Orwoll, E.6
  • 6
    • 84871753207 scopus 로고    scopus 로고
    • Risk factors associated with cardiovascular events during testosterone administration in older men with mobility limitation
    • Basaria S. Davda M. Travison T. Ulloor J. Singh R. Bhasin S. (2013) Risk factors associated with cardiovascular events during testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci 68: 153–160.
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , pp. 153-160
    • Basaria, S.1    Davda, M.2    Travison, T.3    Ulloor, J.4    Singh, R.5    Bhasin, S.6
  • 8
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
    • Bhasin S. Cunningham G. Hayes F. Matsumoto A. Snyder P. Swerdloff R. (2010) Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95: 2536–2559.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.2    Hayes, F.3    Matsumoto, A.4    Snyder, P.5    Swerdloff, R.6
  • 10
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    • Calof O. Singh A. Lee M. Kenny A. Urban R. Tenover J. (2005) Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol 60: 1451–1457.
    • (2005) J Gerontol , vol.60 , pp. 1451-1457
    • Calof, O.1    Singh, A.2    Lee, M.3    Kenny, A.4    Urban, R.5    Tenover, J.6
  • 12
    • 84897748400 scopus 로고    scopus 로고
    • Risks and benefits of late onset hypogonadism treatment: an expert opinion
    • Corona G. Vignozzi L. Sforza A. Maggi M. (2013) Risks and benefits of late onset hypogonadism treatment: an expert opinion. World J Mens Health 31: 103–125.
    • (2013) World J Mens Health , vol.31 , pp. 103-125
    • Corona, G.1    Vignozzi, L.2    Sforza, A.3    Maggi, M.4
  • 13
  • 14
    • 64249137805 scopus 로고    scopus 로고
    • Prostate-specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy
    • Coward R. Simhan J. Carson C. (2008) Prostate-specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy. BJU Int 103: 1179–1183.
    • (2008) BJU Int , vol.103 , pp. 1179-1183
    • Coward, R.1    Simhan, J.2    Carson, C.3
  • 16
    • 84899654297 scopus 로고    scopus 로고
    • Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men
    • Finkle W. Greenland S. Ridgeway G. Adams J. Frasco M. Cook M. (2014) Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. PLOS One 9: 1–7.
    • (2014) PLOS One , vol.9 , pp. 1-7
    • Finkle, W.1    Greenland, S.2    Ridgeway, G.3    Adams, J.4    Frasco, M.5    Cook, M.6
  • 17
    • 44349169518 scopus 로고    scopus 로고
    • Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey
    • Hall S. Araujo A. Esche G. Williams R. Clark R. Travison T. (2008) Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey. Arch Intern Med 168: 1070–1076.
    • (2008) Arch Intern Med , vol.168 , pp. 1070-1076
    • Hall, S.1    Araujo, A.2    Esche, G.3    Williams, R.4    Clark, R.5    Travison, T.6
  • 19
    • 84866682572 scopus 로고    scopus 로고
    • Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial
    • Hoyos C. Killick R. Yee B. Grunstein R. Liu P. (2012a) Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial. Clin Endocrinol (Oxf) 7: 599–607.
    • (2012) Clin Endocrinol (Oxf) , vol.7 , pp. 599-607
    • Hoyos, C.1    Killick, R.2    Yee, B.3    Grunstein, R.4    Liu, P.5
  • 20
    • 84866672073 scopus 로고    scopus 로고
    • Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
    • Hoyos C. Yee B. Phillips C. Machan E. Grunstein R. Liu P. (2012b) Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial. Eur J Endocrinol 167: 531–541.
    • (2012) Eur J Endocrinol , vol.167 , pp. 531-541
    • Hoyos, C.1    Yee, B.2    Phillips, C.3    Machan, E.4    Grunstein, R.5    Liu, P.6
  • 22
    • 84880923151 scopus 로고    scopus 로고
    • Use of testosterone replacement therapy in the United States and its effect on subsequent prostate cancer outcomes
    • Kaplan A. Hu J. (2013) Use of testosterone replacement therapy in the United States and its effect on subsequent prostate cancer outcomes. Urology 82: 321–326.
    • (2013) Urology , vol.82 , pp. 321-326
    • Kaplan, A.1    Hu, J.2
  • 23
    • 84877815412 scopus 로고    scopus 로고
    • The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo-controlled trial
    • Killick R. Wang D. Hoyos C. Yee B. Grunstein R. Liu P. (2013) The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo-controlled trial. J Sleep Res 22: 331–336.
    • (2013) J Sleep Res , vol.22 , pp. 331-336
    • Killick, R.1    Wang, D.2    Hoyos, C.3    Yee, B.4    Grunstein, R.5    Liu, P.6
  • 24
    • 84878730065 scopus 로고    scopus 로고
    • Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men
    • Maggio M. Snyder P. Ceda G. Milaneschi Y. Luci M. Cattabiani C. (2013) Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men. Andrology 1: 24–28.
    • (2013) Andrology , vol.1 , pp. 24-28
    • Maggio, M.1    Snyder, P.2    Ceda, G.3    Milaneschi, Y.4    Luci, M.5    Cattabiani, C.6
  • 25
    • 12944266970 scopus 로고    scopus 로고
    • Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study
    • Mohr B. Guay A. O–Donnell A. McKinlay J. (2005) Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study. Clin Endocrinol 62: 64–73.
    • (2005) Clin Endocrinol , vol.62 , pp. 64-73
    • Mohr, B.1    Guay, A.2    O–Donnell, A.3    McKinlay, J.4
  • 26
    • 79957514411 scopus 로고    scopus 로고
    • Testosterone and prostate cancer: what are the risks for middle-aged men?
    • Morgentaler A. (2011) Testosterone and prostate cancer: what are the risks for middle-aged men? Urol Clin N Am 38: 119–124.
    • (2011) Urol Clin N Am , vol.38 , pp. 119-124
    • Morgentaler, A.1
  • 27
    • 57649176913 scopus 로고    scopus 로고
    • Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth
    • Morgentaler A. Traish A. (2008) Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. Eur Urol 55: 310–321.
    • (2008) Eur Urol , vol.55 , pp. 310-321
    • Morgentaler, A.1    Traish, A.2
  • 28
    • 33745108447 scopus 로고    scopus 로고
    • Prevalence of hypogonadism in males aged at least 45 years: the HIM study
    • Mulligan T. Frick M. Zuraw Q. Stemhagen A. McWhirter C. (2006) Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract 60: 762–769.
    • (2006) Int J Clin Pract , vol.60 , pp. 762-769
    • Mulligan, T.1    Frick, M.2    Zuraw, Q.3    Stemhagen, A.4    McWhirter, C.5
  • 29
    • 84888251991 scopus 로고    scopus 로고
    • Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes
    • Muraleedharan V. Marsh H. Kapoor D. Channer K. Hones T. (2013) Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. Eur J Endocrinol 169: 725–733.
    • (2013) Eur J Endocrinol , vol.169 , pp. 725-733
    • Muraleedharan, V.1    Marsh, H.2    Kapoor, D.3    Channer, K.4    Hones, T.5
  • 30
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in men with low serum T
    • Page S. Amory J. Bowman F. Anawalt B. Matsumoto A. Bremner W. (2005) Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in men with low serum T. J Clin Endocrinol Metab 90: 1502–1510.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.1    Amory, J.2    Bowman, F.3    Anawalt, B.4    Matsumoto, A.5    Bremner, W.6
  • 31
    • 79958287449 scopus 로고    scopus 로고
    • Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy
    • Page S. Hirano L. Gilchriest J. Dighe M. Amory J. Marck B. (2011) Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy. J Urol 186: 191–197.
    • (2011) J Urol , vol.186 , pp. 191-197
    • Page, S.1    Hirano, L.2    Gilchriest, J.3    Dighe, M.4    Amory, J.5    Marck, B.6
  • 32
    • 84888645327 scopus 로고    scopus 로고
    • Testosterone supplementation does not worsen lower urinary tract symptoms
    • Pearl J. Berhanu D. Francois N. Masson P. Zargaroff S. Cashy J. (2013) Testosterone supplementation does not worsen lower urinary tract symptoms. J Urol 190: 1828–1833.
    • (2013) J Urol , vol.190 , pp. 1828-1833
    • Pearl, J.1    Berhanu, D.2    Francois, N.3    Masson, P.4    Zargaroff, S.5    Cashy, J.6
  • 33
    • 84876927454 scopus 로고    scopus 로고
    • Prostate-specific antigen (PSA) concentrations in hypogonadal men during 6 years of transdermal testosterone treatment
    • Raynaud J. Gardette J. Rollet J. Legros J. (2013) Prostate-specific antigen (PSA) concentrations in hypogonadal men during 6 years of transdermal testosterone treatment. BJU Int 111: 880–890.
    • (2013) BJU Int , vol.111 , pp. 880-890
    • Raynaud, J.1    Gardette, J.2    Rollet, J.3    Legros, J.4
  • 34
    • 0042836843 scopus 로고    scopus 로고
    • Hypogonadism and erectile dysfunction: the role for testosterone therapy
    • (Suppl. 4)
    • Shabsigh R. (2003) Hypogonadism and erectile dysfunction: the role for testosterone therapy. Int J Impot Res 15(Suppl. 4): S9–S13.
    • (2003) Int J Impot Res , vol.15 , pp. S9-S13
    • Shabsigh, R.1
  • 35
    • 79751520081 scopus 로고    scopus 로고
    • Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study
    • Shigehara K. Sugimoto K. Konaka H. Iijima M. Fukushima M. Maeda Y. (2011) Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study. The Aging Male 14: 53–58.
    • (2011) The Aging Male , vol.14 , pp. 53-58
    • Shigehara, K.1    Sugimoto, K.2    Konaka, H.3    Iijima, M.4    Fukushima, M.5    Maeda, Y.6
  • 38
    • 65549102804 scopus 로고    scopus 로고
    • Endogenous sex hormone levels in men are not associated with risk of venous thromboembolism: the Tromso study
    • Svartberg J. Braekkan S. Laughlin G. Hansen J. (2009) Endogenous sex hormone levels in men are not associated with risk of venous thromboembolism: the Tromso study. Eur J Endocrinol 160: 833–838.
    • (2009) Eur J Endocrinol , vol.160 , pp. 833-838
    • Svartberg, J.1    Braekkan, S.2    Laughlin, G.3    Hansen, J.4
  • 39
    • 84877707872 scopus 로고    scopus 로고
    • Efficacy and safety of long-acting intramuscular testosterone undecanoate in aging men: a randomized controlled study
    • Tan W. Low W. Ng C. Tan W. Tong S. Ho C. (2013) Efficacy and safety of long-acting intramuscular testosterone undecanoate in aging men: a randomized controlled study. BJU Int 111: 1130–1140.
    • (2013) BJU Int , vol.111 , pp. 1130-1140
    • Tan, W.1    Low, W.2    Ng, C.3    Tan, W.4    Tong, S.5    Ho, C.6
  • 40
    • 84895429600 scopus 로고    scopus 로고
    • Death by testosterone? We think not!
    • Traish A. Guay A. Morgentaler A. (2014) Death by testosterone? We think not! J Sex Med 11: 624–629.
    • (2014) J Sex Med , vol.11 , pp. 624-629
    • Traish, A.1    Guay, A.2    Morgentaler, A.3
  • 41
    • 84896689377 scopus 로고    scopus 로고
    • Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study
    • Traish A. Haider A. Doros G. Saad F. (2013) Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study. Int J Clin Pract 68: 314–329.
    • (2013) Int J Clin Pract , vol.68 , pp. 314-329
    • Traish, A.1    Haider, A.2    Doros, G.3    Saad, F.4
  • 42
    • 84887056433 scopus 로고    scopus 로고
    • Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels
    • Vigen R. O–Donnell C. Baron A. Grunwald G. Maddox T. Bradley S. (2013) Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 310: 1829–1836.
    • (2013) JAMA , vol.310 , pp. 1829-1836
    • Vigen, R.1    O–Donnell, C.2    Baron, A.3    Grunwald, G.4    Maddox, T.5    Bradley, S.6
  • 43
    • 47549107694 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    • Wu F. Tajar A. Pye S. Silman A. Finn J. O–Neill T. (2008) Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 93: 2737–2745.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2737-2745
    • Wu, F.1    Tajar, A.2    Pye, S.3    Silman, A.4    Finn, J.5    O–Neill, T.6
  • 44
    • 84876176964 scopus 로고    scopus 로고
    • Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
    • Xu L. Freeman G. Cowling B. Schooling C. (2013) Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med 11: 108.
    • (2013) BMC Med , vol.11 , pp. 108
    • Xu, L.1    Freeman, G.2    Cowling, B.3    Schooling, C.4
  • 45
    • 84900011854 scopus 로고    scopus 로고
    • Lower urinary tract symptoms improve with testosterone replacement therapy in men with late-onset hypogonadism: 5-year prospective, observational and longitudinal registry study
    • Yassin D. El Douaihy Y. Yassin A. Kashanian J. Shabsigh R. Hammerer P. (2014) Lower urinary tract symptoms improve with testosterone replacement therapy in men with late-onset hypogonadism: 5-year prospective, observational and longitudinal registry study. World J Urol 32: 1049–1054.
    • (2014) World J Urol , vol.32 , pp. 1049-1054
    • Yassin, D.1    El Douaihy, Y.2    Yassin, A.3    Kashanian, J.4    Shabsigh, R.5    Hammerer, P.6
  • 46
    • 84873060080 scopus 로고    scopus 로고
    • IPASS: A study on the tolerability and effectiveness of injectable testosterone undecanoate for the treatment of male hypogonadism in a worldwide sample of 1,438 men
    • Zitzmann M. Mattern A. Hanisch J. Gooren L. Jones H. Maggi M. (2013) IPASS: A study on the tolerability and effectiveness of injectable testosterone undecanoate for the treatment of male hypogonadism in a worldwide sample of 1,438 men. J Sex Med 10: 579–588.
    • (2013) J Sex Med , vol.10 , pp. 579-588
    • Zitzmann, M.1    Mattern, A.2    Hanisch, J.3    Gooren, L.4    Jones, H.5    Maggi, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.