Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26584-26596

  Yoshida, Carolina Andrea ^a   Kawane, Tetsuya ^a   Moriishi, Takeshi ^a   Purushothaman, Anurag ^b,f   Miyazaki, Toshihiro ^a   Komori, Hisato ^a   Mori, Masako ^a   Qin, Xin ^a   Hashimoto, Ayako ^a,c   Sugahara, Kazuyuki ^b,d   Yamana, Kei ^e   Takada, Kenji ^c   Komori, Toshihisa ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Proteoglycan Signaling and Therapeutics Research Group Faculty of Advanced Life Science Frontier Research Center for Post Genomic Science and Technology   (Japan)

^e TEIJIN LTD   (Japan)

^f University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; ENZYMES; ESTERIFICATION; GLYCOSYLATION; POLYSACCHARIDES;

CHONDROCYTE PROLIFERATION; CHONDROCYTES; D-GALACTOSAMINE; GLYCOSAMINOGLYCANS; O-GLYCOSYLATION; OVER-EXPRESSION; PHYSIOLOGICAL ROLES; PROTEOGLYCANS;

GLYCOPROTEINS;

AGGRECAN; CHONDROITIN SULFATE; GLYCOSAMINOGLYCAN; MUCIN; N ACETYLGALACTOSAMINE; PLANT LECTIN; SERINE; TN ANTIGEN; TRANSFERASE; UNCLASSIFIED DRUG; XYLOSE; XYLOSYLTRANSFERASE; AGC1 PROTEIN, MOUSE; N ACETYLGALACTOSAMINYLTRANSFERASE; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; RUNX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL CYCLE; CELL MATURATION; CELL PROLIFERATION; COL2A1 GENE; CONTROLLED STUDY; DWARFISM; EMBRYO; ENCHONDRAL OSSIFICATION; FEMALE; GALNT3 GENE; GENE; GENE OVEREXPRESSION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; TRANSGENIC MOUSE; VICIA; VICIA VILLOSA; 129 MOUSE; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; CARTILAGE; CELL CULTURE; GENE EXPRESSION; GENETICS; GLYCOSYLATION; GROWTH PLATE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PROTEIN PROCESSING;

AGGRECANS; ANIMALS; APOPTOSIS; CARTILAGE; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; CHONDROITIN SULFATES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DWARFISM; FEMALE; GENE EXPRESSION; GLYCOSYLATION; GROWTH PLATE; MALE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; N-ACETYLGALACTOSAMINYLTRANSFERASES; OSTEOGENESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84907212636     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.555987     Document Type: Article

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