Ligand density at the surface of a nanoparticle and different uptake mechanism: Two important factors for successful siRNA delivery to liver endothelial cells

International Journal of Pharmaceutics

Volumn 475, Issue 1, 2014, Pages 227-237

  Akhter, Afsana ^a   Hayashi, Yasuhiro ^a   Sakurai, Yu ^a   Ohga, Noritaka ^a   Hida, Kyoko ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

ApoB 100; KLGR peptide; Liver sinusoidal endothelial cell; siRNA

Indexed keywords

LIGAND; NANOCARRIER; NANOPARTICLE; PEPTIDE DERIVATIVE; PLASMID DNA; SMALL INTERFERING RNA; LIPOSOME; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOSOL; DENSITY; ENDOSOME; ENDOTHELIUM CELL; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER SINUSOID; LIVER SINUSOIDAL ENDOTHELIAL CELL; MALE; NANODEVICE; NONHUMAN; CELL LINE; GENE TRANSFER; LIVER; METABOLISM;

CELL LINE; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; HUMANS; LIGANDS; LIPOSOMES; LIVER; NANOPARTICLES; PEPTIDES; RNA, SMALL INTERFERING;

EID: 84907207630     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.048     Document Type: Article

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