Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome

Molecular Medicine Reports

Volumn 10, Issue 5, 2014, Pages 2322-2326

  Mazzawi, Tarek ^a,b   Gundersen, Doris ^c   Hausken, Trygve ^b   El Salhy, Magdy ^a,b  

^a Stord Helse Fonna Hospital   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c Department of Research ^*  (Norway)

Author keywords

Chromogranin A; Computerized image analysis; Diet; Guts endocrine cells; Immunohistochemistry

Indexed keywords

CHROMOGRANIN A;

ADULT; ARTICLE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIET THERAPY; ENTEROENDOCRINE CELL; FEMALE; FOOD INTAKE; GASTROSCOPY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOCOMPETENT CELL; IRRITABLE COLON; MALE; OUTCOME ASSESSMENT; SECRETORY CELL; STOMACH ANTRUM; STOMACH BIOPSY; ADOLESCENT; AGED; CASE CONTROL STUDY; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH MUCOSA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHROMOGRANIN A; FEMALE; GASTRIC MUCOSA; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; PYLORIC ANTRUM; YOUNG ADULT;

EID: 84907199263     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2498     Document Type: Article

References (45)

1. Moran GW, Leslie FC, Levison SE, Worthington J and McLaughlin JT: Enteroendocrine cells: neglected players in gastrointestinal disorders? Therap Adv Gastroenterol 1: 51-60, 2008.
2. Moran-Ramos S, Tovar AR and Torres N: Diet: friend or foe of enteroendocrine cells - how it interacts with enteroendocrine cells. Adv Nutr 3: 8-20, 2012.
3. Buffa R, Capella C, Fontana P, Usellini L and Solcia E: Types of endocrine cells in the human colon and rectum. Cell Tissue Res 192: 227-240, 1978.
4. El-Salhy M: Irritable bowel syndrome: diagnosis and pathogenesis. World J Gastroenterol 18: 5151-5163, 2012.
5. El-Salhy M, Seim I, Chopin L, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: the role of gut neuroendocrine peptides. Front Biosci (Elite Ed) 4: 2783-2800, 2012.
6. Sandstrom O and El-Salhy M: Ageing and endocrine cells of human duodenum. Mech Ageing Dev 108: 39-48, 1999.
7. El-Salhy M: Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review). Int J Mol Med 24: 727-732, 2009.
8. Tolhurst G, Reimann F and Gribble FM: Intestinal sensing of nutrients. Handb Exp Pharmacol: 309-335, 2012.
9. Lee J, Cummings BP, Martin E, et al: Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol 302: R657-666, 2012.
10. Parker HE, Reimann F and Gribble FM: Molecular mechanisms underlying nutrient-stimulated incretin secretion. Expert Rev Mol Med 12: e1, 2010.
11. Raybould HE: Nutrient sensing in the gastrointestinal tract: possible role for nutrient transporters. J Physiol Biochem 64: 349-356, 2008.
12. San Gabriel A, Nakamura E, Uneyama H and Torii K: Taste, visceral information and exocrine reflexes with glutamate through umami receptors. J Med Invest 56 (Suppl): 209-217, 2009.
13. Rudholm T, Wallin B, Theodorsson E, Naslund E and Hellström PM: Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept 152: 8-12, 2009.
14. Sternini C, Anselmi L and Rozengurt E: Enteroendocrine cells: a site of taste in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 15: 73-78, 2008.
15. Sternini C: Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol 292: G457-461, 2007.
16. Buchan AM: Nutrient tasting and signaling mechanisms in the gut III. Endocrine cell recognition of luminal nutrients. Am J Physiol 277: G1103-G1107, 1999.
17. Montero-Hadjadje M, Elias S, Chevalier L, et al: Chromogranin A promotes peptide hormone sorting to mobile granules in constitutively and regulated secreting cells: role of conserved N-and C-terminal peptides. J Biol Chem 284: 12420-12431, 2009.
18. Shooshtarizadeh P, Zhang D, Chich JF, et al: The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity. Regul Pept 165: 102-110, 2010.
19. El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: diagnosis, pathogenesis and treatment options. Nova Science Publishers, Inc., New York, 2012.
20. Taupenot L, Harper KL and O'Connor DT: The chromogranin-secretogranin family. N Engl J Med 348: 1134-1149, 2003.
21. Wiedenmann B and Huttner WB: Synaptophysin and chromogranins/secretogranins - widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis. Virchows Arch B Cell Pathol Incl Mol Pathol 58: 95-121, 1989.
22. Deftos LJ: Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev 12: 181-187, 1991.
23. El-Salhy M, Gilja OH and Hausken T: Chromogranin A cells in the stomach of patients with sporadic irritable bowel syndrome. Mol Med Rep (In press).
24. El-Salhy M, Hatlebakk JG, Gundersen D and Hausken T: Endocrine cells in the gastric oxyntic mucosa of patients with irritable bowel syndrome. World J Gastroenterol 6: 176-185, 2014.
25. Mazzawi T, Hausken T, Gundersen D and El-Salhy M: Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome. Mol Med Rep 8: 845-852, 2013.
26. Ostgaard H, Hausken T, Gundersen D and El-Salhy M: Diet and effects of diet management on quality of life and symptoms in patients with irritable bowel syndrome. Mol Med Rep 5: 1382-1390, 2012.
27. Spiller RC: Inflammation as a basis for functional GI disorders. Best Pract Res Clin Gastroenterol 18: 641-661, 2004.
28. El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG and Hausken T: Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome. (In press).
29. Spiller R, Aziz Q, Creed F, et al: Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 56: 1770-1798, 2007.
30. El-Salhy M, Mazzawi T, Gundersen D and Hausken T: Chromogranin A cell density in the rectum of patients with irritable bowel syndrome. Mol Med Rep 6: 1223-1225, 2012.
31. Enck P, Klosterhalfen S and Kruis W: Determination of placebo effect in irritable bowel syndrome. Dtsch Med Wochenschr 130: 1934-1937, 2005 (In German).
32. El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG and Hausken T: Is irritable bowel syndrome an organic disorder? World J Gastroenterol 20: 384-400, 2014.
33. El-Salhy M, Hatlebakk JG, Gilja OH and Hausken T: Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment. Expert Rev Gastroenterol Hepatol 8: 435-443, 2014.
34. Barker N and Clevers H: Tracking down the stem cells of the intestine: strategies to identify adult stem cells. Gastroenterology 133: 1755-1760, 2007.
35. Barker N, van de Wetering M and Clevers H: The intestinal stem cell. Genes Dev 22: 1856-1864, 2008.
36. Barker N, van Es JH, Kuipers J, et al: Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007, 2007.
37. Korinek V, Barker N, Moerer P, et al: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19: 379-383, 1998.
38. Cheng H and Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat 141: 537-561, 1974.
39. Fontaine J, Le Lièvre C and Le Douarin NM: What is the developmental fate of the neural crest cells which migrate into the pancreas in the avian embryo? Gen Comp Endocrinol 33: 394-404, 1977.
40. Le Douarin NM and Teillet MA: The migration of neural crest cells to the wall of the digestive tract in avian embryo. J Embryol Exp Morphol 30: 31-48, 1973.
41. Rawdon BB and Andrew A: Origin and differentiation of gut endocrine cells. Histol Histopathol 8: 567-580, 1993.
42. Hoffman J, Kuhnert F, Davis CR and Kuo CJ: Wnts as essential growth factors for the adult small intestine and colon. Cell Cycle 3: 554-557, 2004.
43. May CL and Kaestner KH: Gut endocrine cell development. Mol Cell Endocrinol 323: 70-75, 2010.
44. Inokuchi H, Fujimoto S and Kawai K: Cellular kinetics of gastrointestinal mucosa, with special reference to gut endocrine cells. Arch Histol Jpn 46: 137-157, 1983.
45. Höcker M and Wiedenmann B: Molecular mechanisms of enteroendocrine differentiation. Ann NY Acad Sci 859: 160-174, 1998.