Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice

Endocrinology (United States)

Volumn 155, Issue 10, 2014, Pages 4088-4093

  Ferrara, Alfonso Massimiliano ^a,e   Liao, Xiao Hui ^a   Gil Ibáñez, Pilar ^a,d   Bernal, Juan ^d   Weiss, Roy E ^a,b   Dumitrescu, Alexandra M ^a   Refetoff, Samuel ^a,b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d CSIC   (Spain)

^e VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE TYPE 1A3; DIIODOTHYROPROPIONIC ACID; KRUPPEL LIKE FACTOR; LEVOTHYROXINE; MONOCARBOXYLATE TRANSPORTER 8; PROPIONIC ACID DERIVATIVE; SONIC HEDGEHOG PROTEIN; THYROID HORMONE DERIVATIVE; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG; 3,5-DIIODOTHYROPROPIONIC ACID; CARRIER PROTEIN; DIIODOTHYRONINE; SLC16A2 PROTEIN, MOUSE; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TRANSPORT; EMBRYO; FEMALE; GENOTYPE; MALE; NONHUMAN; PLACENTAL TRANSFER; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT OUTCOME; ANIMAL; ANIMAL EMBRYO; BLOOD; DEFICIENCY; FETOMATERNAL TRANSFUSION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; NEWBORN; PLACENTA; PREGNANCY; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL TRANSPORT; DIIODOTHYRONINES; EMBRYO, MAMMALIAN; FEMALE; MALE; MATERNAL-FETAL EXCHANGE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; PLACENTA; PREGNANCY; PROPIONATES; THYROID HORMONES; THYROXINE; TISSUE DISTRIBUTION;

EID: 84907190430     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1085     Document Type: Article

References (20)

1. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S. Tissuespecific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology. 2006;147: 4036-4043.
2. Trajkovic M, Visser TJ, Mittag J, et al. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 1. J Clin Invest. 2007;117:627-635111
3. Bernal J. Thyroid hormones and brain development. Vitam Horm. 2005;71:95-122.
4. Dumitrescu AM, Refetoff S. The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta. 2013;1830:3987-4003.
5. Di Cosmo C, Liao XH, Ye Het al. Mct8-deficient mice have increased energy expenditure and reduced fat mass that is abrogated by normalization of serum T3 levels. Endocrinology. 2013;154: 4885-4895.
6. Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S. A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology. 2009; 150:4450-4458.
7. Verge CF, Konrad D, Cohen M, et al. Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency. J Clin Endocrinol Metab. 2012;97:4515-4523.
8. VisserWE,Visser TJ. Finding the way into the brain withoutMCT8. J Clin Endocrinol Metab. 2012;97:4362-4365.
9. Fu J, Refetoff S, Dumitrescu AM. Inherited defects of thyroid hormone-cell-membrane transport: Review of recent findings. Curr Opin Endocrinol Diabetes Obes. 2013;20:434-440.
10. Ferrara AM, Liao XH, Gil-Ibáñez P, et al. Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013;154:2533-2541.
11. Grijota-Martínez C, Díez D, Morreale de Escobar G, Bernal J, Morte B. Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 2. Endocrinology. 2011;152:1713-1721
12. Vié MP, Evrard C, Osty J, et al. Purification, molecular cloning, and functional expression of the human nicodinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein. Mol Endocrinol. 1997;11:1728-1736.
13. Horn S, Kersseboom S, Mayerl S, et al. Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. Endocrinology. 2013;154: 968-979.
14. Wémeau JL, Pigeyre M, Proust-Lemoine E, et al. Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8. J Clin Endocrinol Metab. 2008;93:2084-2088.
15. Filho HC, Marui S, Manna TD, et al. Novel mutation inMCT8gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities. Arq Bras Endocrinol Metabol. 2011;55:60-66.
16. Visser WE, Vrijmoeth P, Visser FE, Arts WF, van Toor H, Visser TJ. Identification, functional analysis, prevalence and treatment of monocarboxylate transporter 8 (MCT8) mutations in a cohort of adult patients with mental retardation. Clin Endocrinol (Oxf). 2013;78:310-315.
17. Zung A, Visser TJ, Uitterlinden AG, Rivadeneira F, Friesema EC. A child with a deletion in the monocarboxylate transporter 8 gene: 7-year follow-up and effects of thyroid hormone treatment. Eur J Endocrinol. 2011;165:823-830.
18. Hayashida CY, Duarte AJ, Sato AE, Yamashiro-Kanashiro EH. Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil. J Endocrinol Invest. 1990;13:937-941.
19. Taylor P, Bhatt S, Gouni R, Quinlan J, Robinson T. A Case of Propylthiouracil-Induced Hepatitis during Pregnancy. Eur Thyroid J. 2012;1:41-44.
20. Korelitz JJ, McNally DL, Masters MN, Li SX, Xu Y, Rivkees SA. Prevalence of thyrotoxicosis, antithyroid medication use, and complications among pregnant women in the United States. Thyroid. 2013;23:758-765.