Intranasal administration as a route for drug delivery to the brain: Evidence for a unique pathway for albumin

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 1, 2014, Pages 54-60

  Falcone, Joseph A ^a,b   Salameh, Therese S ^a,b   Yi, Xiang ^b,c   Cordy, Benjamin J ^b   Mortell, William G ^b   Kabanov, Alexander V ^c,d   Banks, William A ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALBUMIN I 125; BOVINE SERUM ALBUMIN; IODINE 125; LEPTIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; DRUG VEHICLE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD LEVEL; BRAIN LEVEL; BRAIN REGION; CAVEOLA; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG UPTAKE; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; OLFACTORY BULB; OLFACTORY CORTEX; PARIETAL CORTEX; RADIOACTIVITY; TRANSCYTOSIS; ANIMAL; BRAIN; DRUG EFFECTS; INTRANASAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; LEPTIN; MALE; MICE; PHARMACEUTICAL VEHICLES; SERUM ALBUMIN, BOVINE; TETRADECANOYLPHORBOL ACETATE; TISSUE DISTRIBUTION;

EID: 84907164680     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.216705     Document Type: Article

References (41)

1. Banks WA and Broadwell RD (1994) Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments. J Neurochem 62:2404-2419.
2. Banks WA, During MJ, and Niehoff ML (2004) Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration. J Pharmacol Exp Ther 309:469-475.
3. Banks WA, Morley JE, Niehoff ML, and Mattern C (2009) Delivery of testosterone to the brain by intranasal administration: comparison to intravenous testosterone. J Drug Target 17:91-97.
4. Benedict C, Frey WH, 2nd, Schiöth HB, Schultes B, Born J, and Hallschmid M (2011) Intranasal insulin as a therapeutic option in the treatment of cognitive impairments. Exp Gerontol 46:112-115.
5. Bergson P, Lipkind G, Lee SP, Duban M-E, and Hanck DA (2011) Verapamil block of T-type calcium channels. Mol Pharmacol 79:411-419.
6. Charlton ST, Whetstone J, Fayinka ST, Read KD, Illum L, and Davis SS (2008) Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model. Pharm Res 25:1531-1543.
7. Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, Arbuckle M, Callaghan M, Tsai E, and Plymate SR, et al. (2012) Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 69:29-38.
8. Dhuria SV, Hanson LR, and Frey WH, 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99: 1654-1673.
9. Elsadek B and Kratz F (2012) Impact of albumin on drug delivery: new applications on the horizon. J Control Release 157:4-28.
10. Farr SA, Banks WA, and Morley JE (2006) Effects of leptin on memory processing. Peptides 27:1420-1425.
11. Frey WH, II (2002) Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord. J Drug Deliv Sci Technol 2:46-49.
12. Glowinski J and Iversen LL (1966) Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 13:655-669.
13. Greenwood FC, Hunter WM, and Glover JS (1963) The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochem J 89:114-123.
14. Guillot FL and Audus KL (1990) Angiotensin peptide regulation of fluid-phase endocytosis in brain microvessel endothelial cell monolayers. J Cereb Blood Flow Metab 10:827-834.
15. Hastings RH, Wright JR, Albertine KH, Ciriales R, and Matthay MA (1994) Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol 266:L544-L552.
16. Hiruma H, Shimizu K, Takenami T, Sugie H, and Kawakami T (2008) Effects of clonidine on lidocaine-induced inhibition of axonal transport in cultured mouse dorsal root ganglion neurones. Br J Anaesth 101:659-665.
17. Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, and Benveniste H (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299-1309.
18. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, et al. (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 4:147ra111.
19. Knutson VP, Ronnett GV, and Lane MD (1983) Rapid, reversible internalization of cell surface insulin receptors: correlation with insulin-induced down-regulation. J Biol Chem 258:12139-12142.
20. Kratz F (2008) Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 132:171-183.
21. Kratz F and Elsadek B (2012) Clinical impact of serum proteins on drug delivery. J Control Release 161:429-445.
22. Lavoie PA, Khazen T, and Filion PR (1989) Mechanisms of the inhibition of fast axonal transport by local anesthetics. Neuropharmacology 28:175-181.
23. Lochhead JJ and Thorne RG (2012a) Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev 64:614-628.
24. Lohmann C, Krischke M, Wegener J, and Galla HJ (2004) Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinasedependent and -independent pathways. Brain Res 995:184-196.
25. Migliore MM, Vyas TK, Campbell RB, Amiji MM, and Waszczak BL (2010) Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations. J Pharm Sci 99: 1745-1761.
26. Nonaka N, Farr SA, Nakamachi T, Morley JE, Nakamura M, Shioda S, and Banks WA (2012) Intranasal administration of PACAP: uptake by brain and regional brain targeting with cyclodextrins. Peptides 36:168-175.
27. Pardridge WM, Eisenberg J, and Cefalu WT (1985) Absence of albumin receptor on brain capillaries in vivo or in vitro. Am J Physiol 249:E264-E267.
28. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, and Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543.
29. Reger MA, Watson GS, Green PS, Baker LD, Cholerton B, Fishel MA, Plymate SR, Cherrier MM, Schellenberg GD, and Frey WH, 2nd, et al. (2008) Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloidbeta in memory-impaired older adults. J Alzheimers Dis 13:323-331.
30. Schinkel AH (1999) P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36:179-194.
31. Schnitzer JE (1992) gp60 is an albumin-binding glycoprotein expressed by continuous endothelium involved in albumin transcytosis. Am J Physiol 262: H246-H254.
32. Schnitzer JE, Oh P, Pinney E, and Allard J (1994) Filipin-sensitive caveolaemediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol 127:1217-1232.
33. Schulz C, Paulus K, Jöhren O, and Lehnert H (2012) Intranasal leptin reduces appetite and induces weight loss in rats with diet-induced obesity (DIO). Endocrinology 153: 143-153.
34. Searl TJ and Silinsky EM (2000) The phosphatidylinositol 4-kinase inhibitor phenylarsine oxide blocks evoked neurotransmitter release by reducing calcium entry through N-type calcium channels. Br J Pharmacol 130:418-424.
35. Stamatovic SM, Keep RF, and Andjelkovic AV (2008) Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol 6:179-192.
36. Thorne RG, Pronk GJ, Padmanabhan V, and Frey WH, 2nd (2004) Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127: 481-496.
37. Tiruppathi C, Song W, Bergenfeldt M, Sass P, and Malik AB (1997) Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway. J Biol Chem 272:25968-25975.
38. Toker A (1998) The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr Opin Cell Biol 10:254-261.
39. Veening JG and Olivier B (2013) Intranasal administration of oxytocin: behavioral and clinical effects, a review. Neurosci Biobehav Rev 37:1445-1465.
40. Wiedemann C, Schafer T, Burger MM and Sihra TS (1998) An essential role for a small synaptic vesicle-associated phosphatidylinositol 4-kinase in neurotransmitter release. J Neurosci 18:5594-5602.
41. Wu-Zhang AX and Newton AC (2013) Protein kinase C pharmacology: refining the toolbox. Biochem J 452:195-209.