Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Yang, Weiwei ^a   Li, Qinghua ^a   Pan, Zhifang ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; UNCLASSIFIED DRUG; COLLAGEN; DRUG COMBINATION; LAMININ; LYSOPHOSPHOLIPID; MAP2K1 PROTEIN, HUMAN; MAP2K2 PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN; MATRIGEL; PROTEIN KINASE INHIBITOR; PROTEOGLYCAN; S1PR1 PROTEIN, HUMAN; SMALL INTERFERING RNA; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ARTICLE; CELL INVASION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TROPHOBLAST; UPREGULATION; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOASSAY; CELL MOTION; CHEMISTRY; CYTOLOGY; DIFFUSION CHAMBER; DRUG COMBINATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

BIOLOGICAL ASSAY; CELL LINE; CELL MOVEMENT; COLLAGEN; DIFFUSION CHAMBERS, CULTURE; DRUG COMBINATIONS; GENE EXPRESSION REGULATION; HUMANS; LAMININ; LYSOPHOSPHOLIPIDS; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MATRIX METALLOPROTEINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE INHIBITORS; PROTEOGLYCANS; RECEPTORS, LYSOSPHINGOLIPID; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHINGOSINE; TROPHOBLASTS;

EID: 84907096996     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106725     Document Type: Article

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