Mitigation of experimental radiation nephropathy by renin-equivalent doses of angiotensin converting enzyme inhibitors

International Journal of Radiation Biology

Volumn 90, Issue 9, 2014, Pages 762-768

  Moulder, John E ^a   Cohen, Eric P ^a,b   Fish, Brian L ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

ACE inhibitors; Captopril; Mitigation; Plasma renin activity; Radiation nephropathy; Total body irradiation

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; FOSINOPRIL; LISINOPRIL; RAMIPRIL; BIOLOGICAL MARKER; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; KIDNEY DISEASE; MALE; NONHUMAN; PLASMA RENIN ACTIVITY; RADIATION; RADIATION INJURY; RADIATION NEPHROPATHY; RADIATION PNEUMONIA; RAT; UREMIA; WHOLE BODY RADIATION; ACE INHIBITORS; ANIMAL; BLOOD; CALIBRATION; CHEMISTRY; KIDNEY; METABOLISM; MITIGATION; RADIATION EXPOSURE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ACE INHIBITORS; CAPTOPRIL; MITIGATION; PLASMA RENIN ACTIVITY; RADIATION NEPHROPATHY; TOTAL BODY IRRADIATION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW TRANSPLANTATION; CALIBRATION; CAPTOPRIL; ENALAPRIL; FOSINOPRIL; KIDNEY; KIDNEY DISEASES; LISINOPRIL; MALE; RADIATION INJURIES; RAMIPRIL; RATS; RENIN; RENIN-ANGIOTENSIN SYSTEM; WHOLE-BODY IRRADIATION;

EID: 84907045097     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2014.938375     Document Type: Article

References (42)

1. Arthur JM , Hill EG , Alge JL , Lewis EC , Neely BA , Janech MG , Tumlin JA , Chawla LS , Shaw AD . 2014. Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery . Kidney Int 85 : 431-438 .
2. Athyros VG , Mikhailidis DP , Kakafi ka AI , Tziomalos K , Karagiannis A . 2007 . Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: Is oral renin inhibition the solution? Expert Opin Pharmacother 8: 529-535.
3. Berger R , Kuchling G , Frey B , Kozanly I , Pacher R , Stanek B . 2000 . ACE inhibitor dosage at the time of listing predicts survival . J Heart Lung Transplant 19 : 127-133 .
4. Brown NJ , Vaughan DE . 1998 . Angiotensin-converting enzyme inhibitors . Circulation 97 : 1411-1420 .
5. Brownlee KA . 1965. Simple linear regression. In: Statistical theory and methodology in science and engineering , 2nd ed . New York: John Wiley & Sons, Inc. pp 605-611.
6. Brunner HR, Laragh JH, Baer L , Newton MA , Goodwin FT , Krakoff LR , Bard RH , Buhler FR . 1972 . Essential hypertension: Renin and aldosterone, heart attack and stroke . New Eng J Med 286: 441-449.
7. Cohen EP , Bedi M , Irving AA , Jacobs ER , Tomic R , Klein JP , Lawton CA , Moulder JE . 2012 . Mitigation of late renal and pulmonary injury after hematopoietic stem cell transplantation . Int J Rad Oncol Biol Phys 83 : 292-296 .
8. Cohen EP , Fish BL , Moulder JE . 2002 . The renin-angiotensin system in experimental radiation nephropathy . J Lab Clin Med 139 : 251-257 .
9. Cohen EP , Fish BL , Moulder JE . 2010 . Mitigation of radiation injuries via suppression of the renin-angiotensin system: Emphasis on radiation nephropathy. Cur Drug Targets 11: 1423-1429.
10. Cohen EP , Joines MM , Moulder JE . 2008 . Prevention and treatment of radiation injuries-the role of the renin-angiotensin system . In: Rubin P , Constine LS , Mark LB , Okunieff P , editors . Late Effects of cancer treatment on normal tissues . Heidelberg, Germany: Springer-Verlag . pp 69-76.
11. Cohen EP , Molteni A , Hill P , Fish BL , Ward WF , Moulder JE , Carone FA . 1996 . Captopril preserves function and ultrastructure in experimental radiation nephropathy. Lab Invest 75: 349-360.
12. Cohen EP , Moulder JE , Fish BL , Hill P . 1994 . Prophylaxis of experimental bone marrow transplant nephropathy . J Lab Clin Med 124 : 371-380 .
13. Cravedi P , Ruggenenti P , Remuzzi G . 2007. Intensifi ed inhibition of renin-angiotensin system: A way to improve renal protection? Cur Hyper Rep 9: 430-436.
14. Cushman DW , Wang FL , Fung WC , Grover GJ , Harvey CM, Scalese RJ , Mitch SL , DeForrest JM . 1989a . Comparisons in vitro, ex vivo , and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE) . Brit J Clin Pharmacol 28(Suppl. 2): 115S-130S .
15. Cushman DW , Wang FL , Fung WC , Harvey CM , DeForrest JM . 1989b . Diff erentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs . Amer J Hypertens 2: 294-306.
16. Cushman WC , Evans GW , Byington RP , Goff DC , Grimm RH , Cutler JA , Simons-Morton DG , Basile JN , Corson MA , Probstfi eld JL , Katz L , Peterson KA , Friedewald WT , Buse JB , Bigger JT , Gerstein HC , Ismail-Beigi F . 2010. Effects of intensive bloodpressure control in type 2 diabetes mellitus . New Engl J Med 362 : 1575-1585 .
17. Ferguson RK , Turini GA , Brunner HR, Gavras H, McKinstry DN . 1977. A specifi c orally active inhibitor of angiotensin-converting enzyme in man . Lancet 309 : 775-778 .
18. Friereich EJ , Gehan EA , Rall DP , Schmidt LH , Skipper HE . 1966 . Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man . Cancer Chemo Rep 50 : 219-244 .
19. Furberg CD , Pitt B . 2001 . Are all angiotensin-converting enzyme inhibitors interchangeable? J Amer Coll Cardiol 37: 1456-1460.
20. Garg R, Yusuf S . 1995. Overview of randomized trials of angiotensinconverting enzyme inhibitors on mortality and morbidity in patients with heart failure . JAMA 273 : 1450-1456 .
21. Graves PR, Siddiqui F , Anscher MS , Movsas B . 2010. Radiation pulmonary toxicity: From mechanisms to management . Sem Rad Oncol 20 : 201-207 .
22. Jenrow KA , Brown SL , Liu J , Kolozsvary A , Kim JH . 2010. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus . Radiat Oncol 5: Article 6.
23. Kharofa JR , Cohen EP , Tomic R , Xiang Q , Gore E . 2012 . Decreased risk of radiation pneumonitis with incidental concurrent use of angiotensin-converting enzyme inhibitors and thoracic radiation therapy. Int J Rad Oncol Biol Phys 84: 238-243.
24. Kma L , Gao F , Fish BL , Moulder JE , Jacobs ER , Medhora M . 2012 . Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax . J Rad Res 32: 10-17.
25. Kovesdy CP , Bleyer AJ , Molnar MZ , Ma JZ , Sim JJ , Cushman WC , Quarles LD , Kalantar-Zadeh K . 2013 . Blood pressure and mortality in U.S. veterans with chronic kidney disease: A cohort study . Ann Int Med 159 : 233-242 .
26. Lee ET , Desu MM . 1972. A computer program for comparing K samples with right-censored data . Comp Prog Biomed 2 : 315-321 .
27. Lenarczyk M , Lam V , Jensen E , Fish BL , Su J , Kaprowski S , Komoriwski RA , Harmann L , Migrino RQ , Li XA , Hopewell JW , Moulder JE , Baker JE . 2013 . Cardiac injury following 10 Gy total body irradiation: Indirect role of Effects on abdominal organs . Radiat Res 180 : 247-258 .
28. Ma CM , Coff ey CW , DeWerd LA , Liu C , Nath R , Seltzer SM , Seuntjens JP . 2001 . AAPM protocol for 40-300 kV x-ray beam dosimetry in radiotherapy and radiobiology . Med Phys 28: 868-893.
29. Molteni A , Moulder JE , Cohen EP , Ward WF , Fish BL , Taylor JM , Wolfe LF , Brizio-Molteni L , Veno P . 2000 . Control of radiationinduced pneumopathy and lung fi brosis by angiotensin converting enzyme inhibitors and an angiotensin II type 1 receptor blocker . Int J Radiat Biol 76: 523-532.
30. Moulder JE . 2014 . The 2013 Dade W. Moeller Lecture: Medical countermeasures against radiological terrorism . Health Phys 107: 164-171.
31. Moulder JE , Cohen EP , Fish BL . 2011 . Captopril and losartan for mitigation of renal injury caused by single-dose total body irradiation . Radiat Res 175: 29-36.
32. Moulder JE , Cohen EP , Fish BL , Hill P . 1993 . Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme . Radiat Res 136: 404-407.
33. Moulder JE , Fish BL . 1989 . Late toxicity of total body irradiation with bone marrow transplantation in a rat model . Int J Rad Oncol Biol Phys 16: 1501-1509.
34. Moulder JE , Robbins MEC , Cohen EP , Hopewell JW , Ward WF . 1998. Pharmacologic modifi cation of radiation-induced late normal tissue injury. Cancer Treat Res 93: 129-151.
35. Moulder JE, Rockwell S . 1984. Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data . Int J Rad Oncol Biol Phys 10: 695-712.
36. Pacher R , Stanek B , Globits S , Berger R , H ü lsmann M , Wutte M , Frey B , Schuller M , Hartter E , Ogris E . 1996 . Effects of two diff erent enalapril dosages on clinical, haemodynamic and neurohumoral response of patients with severe congestive heart failure . Eur Heart J 17 : 1223-1232 .
37. Reagan-Shaw S , Nihal M, Ahmad N . 2008. Dose translation from animal to human studies revisited . FASEB J 22 : 659-661 .
38. Ricketts ML , Stewart PM . 1999. Regulation of 11 ə -hydroxysteroid dehydrogenase type 2 by diuretics and the renin-angiotensinaldosterone axis . Clin Sci (Lond) 96 : 669-675 .
39. Riddle MC , McDaniel PA . 1994. Renal 11 beta-hydroxysteroid dehydrogenase activity is enhanced by ramipril and captopril . J Clin Endocrinol Metab 78: 830-834.
40. Robbins MEC , Hopewell JW . 1986. Physiological factors eff ecting renal radiation tolerance: A guide to the treatment of late Effects . Br J Cancer 53(Suppl. VII): 265-267.
41. Sealey JE , Laragh JH . 1977 . How to do a plasma renin assay . Cardiovasc Med 2 : 1079-1092 .
42. Ward WF , Molteni A , Kim YT , Ts ' ao C . 1989. Structure-function analysis of angiotensin-converting enzyme inhibitors as modifi ers of radiation-induced pulmonary endothelial dysfunction in rats . Brit J Radiol 62: 348-354.