Evaluation of leptin and leptin receptor gene 3′ UTR polymorphisms in essential hypertension

Clinical and Experimental Hypertension

Volumn 36, Issue 6, 2014, Pages 419-425

  Nagalingam, Swapna ^a   Uppuluri, Mohana Vamsi ^a   Gunda, Padma ^a   Ravishanker, Usha ^b   Tirunilai, Padma ^a  

^a OSMANIA UNIVERSITY   (India)

^b Durga Bai Deshmukh Hospital and Research Centre   (India)

Author keywords

3 UTR polymorphism; Essential hypertension; Leptin gene; Leptin receptor gene

Indexed keywords

DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MICROSATELLITE DNA;

3' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA FLANKING REGION; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; FAMILY HISTORY; FEMALE; GENE AMPLIFICATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE REPEAT; OBESITY; SYSTOLIC BLOOD PRESSURE; TETRANUCLEOTIDE REPEAT; BLOOD PRESSURE; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; HYPERTENSION; INDIA; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALLELES; BLOOD PRESSURE; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; HYPERTENSION; INDIA; LEPTIN; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN;

EID: 84907019303     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.3109/10641963.2013.846356     Document Type: Article

References (39)

1. Kaufman JS, Durazo-Avizu RA, Rotimi CN, et al. Obesity and hypertension prevalence in populations of African origin: results from the International Collaborative Study on Hypertension in Blacks. Epidemiology 1996;7:398-405.
2. Stamler R, Stamler J, Riedlinger WF, et al. Weight and blood pressure: findings in hypertension screening of 1 million Americans. JAMA 1978;240:1607-10.
3. Kannel WB, Brand N, Skinner Jr JJ, et al. The relation of adiposity to blood pressure and development of hypertension. Ann Intern Med 1967;67:48-59.
4. Rumantir MS, Vaz M, Jennings GL, et al. Neural mechanisms in human obesity-related hypertension. J Hypertens 1999;17:1125-33.
5. Esler M. The sympathetic system and hypertension. Am J Hypertens 2000;13:99S-105S.
6. Rocchini AP, Katch V, Kveselis D, et al. Insulin and renal sodium retention in obese adolescents. Hypertension 1989;14:367-74.
7. Tuck ML. Obesity, the sympathetic nervous system, and essential hypertension. Hypertension 1992;19:167-77.
8. Rosmond R, Dallman MF, Bjorntorp P. Stress-related cortisol in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 1998;83:1853-9.
9. Freidman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-9.
10. Mantzoros CS, Flier JS. Leptin as a therapeutic agent: trials and tribulations. J Clin Endocrinol Metab 2000;85:400-2.
11. Woods AJ, Stock MJ. Leptin activation in hypothalamus. Nature 1996;81:745.
12. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999;130: 871-81.
13. Dunber JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997;46:2040-3.
14. Casto RM, Van Ness JM, Overton JM. Effects of central leptin administration on blood pressure in normotensive rats. Neurosci Lett 1998;246:29-32.
15. Shek E, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998;31(Pt 2):409-14.
16. Agata J, Masuda A, Takada M, et al. High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 1997;10: 1171-4.
17. Suter PM, Locher R, Häsler E, Vetter W. Is there a role for the ob gene product leptin in essential hypertension?. Am J Hypertens 1998;11:1305-11.
18. Takizawa H, Ura N, Saitoh S, et al. Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension. Clin Exp Hypertens 2001;23:357-68.
19. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83: 1263-71.
20. Zhang Y, Proneca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372: 425-32.
21. Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996;84: 491-5.
22. Maffei M, Fei H, Lee GH, et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995;92: 6957-60.
23. Considine RV, Considine EL, Williams CJ, et al. The hypothalamus leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996;19:992-4.
24. Lahiri DK, Nurnberger Jr JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic acids Res 1991;19:5444.
25. Shintani M, Ikegami H, Fujisawa T, et al. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab 2002;87:2909-12.
26. Chung WK, Power-Kehoe L, Chua M, et al. Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 1997;46:1509-11.
27. Moore JH, Gilbert JC, Tsai CT, et al. A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J Theor Biol 2006;241:252-61.
28. Aizawa-Abe M, Ogawa Y, Masuzaki H, et al. Patho-physiological role of leptin in obesity-related hypertension. J Clin Invest 2000; 105:1243-52.
29. Akhter Q, Masood A, Ashraf R, et al. Polymorphisms in the 30 UTR of the human leptin gene and their role in hypertension. Mol Med Report 2012;5:1058-62.
30. Maestrini S, Mencarelli M, Verti B, et al. Lack of association between the tetranucleotide repeat polymorphism in the 30-flanking region of the leptin gene and hypertension in severely obese patients. J Endocrinol Invest 2006;29:776-80.
31. Haynes WWG, Morgan DA, Walsh SA, et al. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100:270-8.
32. Karlson C, Lindell K, Ottoson M, et al. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 1998;83:3925-9.
33. Frederich RCJ, Kahn BB, Peach MJ, Flier JS. Tissue specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 1992;19:339-44.
34. Schorr U, Blaschke K, Turan S, et al. Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men. J Hypertens 1998;16:1475-14.
35. Suter PM, Locher R, Häsler E, Vetter W. Is there a role for the ob gene product leptin in essential hypertension?. Am J Hypertens 1998;11:1305-11.
36. Uçkaya G, Ozata M, Sonmez A, et al. Plasma leptin levels strongly correlate with plasma renin activity in patients with essential hypertension. Horm Metab Res 1999;31:435-8.
37. Aubert J, Darimont C, Safonova I, et al. Regulation by glucocorticoids of angiotensinogen gene expression and secretion in adipose cells. Biochem J 1997;328:701-6.
38. Jones BH, Standridge MK, Taylor JW, Moustaid N. Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am J Physiol 1997;273:R236-42.
39. Koletsky RJ, Ernsberger P. Phenotypic characterization of a genetically obese and hypertensive rat. Rat Genome 1996;2:10-22.