Punica granatum: A review on its potential role in treating periodontal disease

Journal of Indian Society of Periodontology

Volumn 18, Issue 4, 2014, Pages 428-432

  Prasad, Divyashree ^a   Kunnaiah, Ravi ^a  

^a MES Dental College and Hospital   (India)

Author keywords

Gingivitis; Periodontal therapy; Periodontitis; Pomegranate; Punica granatum

Indexed keywords

EID: 84907016377     PISSN: 0972124X     EISSN: 09751580     Source Type: Journal    
DOI: 10.4103/0972-124X.138678     Document Type: Review

References (65)

1. Somu CA, Ravindra S, Ajith S, Ahmed MG. Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study. J Ayurveda Integr Med 2012;3:85-90.
2. Informational Paper: The pathogenesis of periodontal diseases. J Periodontol 1999;70:450-70.
3. Kornman KS. Mapping the pathogenesis of periodontitis: A New Look. J Periodontol 2008;79:1560-8.
4. Jolkovsky DL, Ciancio SG. Chemotherapeutic Agents. In: Takei HH, editor. Carranza's clinical periodontology. 10 th ed. Missouri: W.B. Saunders Company; 2006. p. 798-812.
5. Sangeetha J, Vijayalakshmi K. Antimicrobial activity of rind extracts of Punica granatum Linn. The Bioscan 2011;6:119-24.
6. Abdollahzdeh SH, Mashouf R, Mortazavi H, Moghaddam M, Roozbahani N, Vahedi M. Antibacterial and Antifungal activities of Punica granatum Peel extracts against Oral Pathogens. J Dent (Tehran) 2011;8:1-6.
7. Salgado AD, Maia JL, Pereira SL, de Lemos TL, Mota OM. Antiplaque and antigingivitis effects of a gel containing Punica granatum linn extract. A double-blind clinical study in humans. J Appl Oral Sci 2006;14:162-6.
8. Jurenka JS. Therapeutic applications of Pomegranate (Punica granatum L.): A review. Altern Med Rev 2008;13:128-44.
9. Bhandari PR. Pomegranate (Punica granatum L). Ancient seeds for modern cure? Review of potential therapeutic applications. Int J Nutr Pharmacol Neurol Dis 2012;2:171-84.
10. Viuda-Martos M, Fernández-López J, Pérez-Álvarez JA. Pomegranate and its many functional components as related to human health: A review. Compr Rev Food Sci Food Saf 2010;9:635-54.
11. Saxena A, Vikram NK. Role of selected Indian plants in management of type 2 diabetes: A review. J Altern Complement Med 2004;10:369-78.
12. Naqvi S, Khan MSY, Vohora SB. Anti-bacterial, anti-fungal and anthelmintic investigations on Indian medicinal plants. Fitoterapia 1991;62:221-8.
13. Prakash CVS, Prakash I. Bioactive Chemical Constituents from Pomegranate (Punica granatum) Juice, Seed and Peel-A Review. Int J Res Chem Environ 2011;1:1-18.
14. Miguel MG, Neves MA, Antunes MD. Pomegranate (Punica granatum L.): A medicinal plant with myriad biologic properties: A short review. J Med Plants Res 2010;4:2836-47.
15. Ishikawa I. Host Responses in periodontal diseases: A preview. Periodontol 2000 2007;43:9-13.
16. Arun N, Singh DP. Punica granatum: A review on pharmacological and therapeutic properties. IJPSR 2012;3:1240-5.
17. Gracious Ross R, Selvasubramanian S, Jayasundar S. Immunomodulatory activity of Punica granatum in rabbits-a preliminary study. J Ethnopharmacol 2001;78:85-7.
18. Koide M, Kinugawa S, Takahashi N, Udagawa N. Osteoclastic bone resorption induced by innate immune responses. Periodontol 2000 2010;54:235-46.
19. Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE 2 production in human chondrocytes in vitro. J Inflamm (Lond) 2008;5:9.
20. Pereira JV, Pereira MDSV, Higino JS, Sampio FC, Alves PM, Araujo CRF. Studies with the extract of the Punica granatum Linn.(Pomegranate): Antimicrobial effect "in vitro" and clinical evaluation of a toothpaste upon microorganisms of the oral biofilm. Journal of Dental Science 2005;20:262-9.
21. Bhadbhade SJ, Acharya AB, Rodrigues SV, Thakur SL. The antiplaque efficacy of pomegranate mouthrinse. Quintessence Int 2011;42:29-36.
22. Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol 2003;5:106-15.
23. Sastravaha G, Gassmann G, Sangtherapitikul P, Grimm WD. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol 2005;7:70-9.
24. DiSilvestro RA, DiSilvestro DJ, DiSilvestro DJ. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res 2009;23:1123-7.
25. Nomura Y, Tamaki Y, Tanaka T, Arakawa H, Tsurumoto A, Kirimura K, et al. Screening of periodontitis with salivary enzyme tests. J Oral Sci 2006;48:177-83.
26. Narhi TO, Tenovuo J, Ainamo A, Vilja P. Antimicrobial factors, sialic acid, and protein concentration in whole saliva of the elderly. Scan J Den Res 1994;102:120-5.
27. Badria FA, Zidan OA. Natural products for dental caries prevention. J Med Food 2004;7:381-4.
28. Pereira JV, Silva SC, Filho LS, Higino JS. Antimicrobial activity of hyroalcoholic extract of Punica granatum Linn. on plaque forming microorganisms. Periodontics Rev 2001;12:57-64.
29. Pereira JV, Pereira MSV, Sampo FC, Sampio MCC, Alves PM, Araujo CRF, et al. In vitro antibacterial and adherence effect of the extract of Punica granatum Linn. upon dental biofilm microorganisms. J. Braz. Pharmacogn 2006;16:88-93.
30. Menezes SM, Cordeiro LN, Viana GS. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother 2006;6:79-92.
31. Vahabi S, Najafi E, Alizadeh S. In vitro antimicrobial effects of some herbal essences against oral pathogens. J Med Plants Res 2011;5:4870-8.
32. Kote S, Kote S, Nagesh L. Effect of pomegranate juice on dental plaque microorganisms (Streptococci and Lactobacilli). Anc Sci Life 2011;31:49-51.
33. Ahuja S, Dodwad V, Kukreja BJ, Mehra P, Kukreja P. A comparative evaluation of efficacy of Punica granatum and chlorhexidine on plaque and gingivitis. J Int Clin Dent Res Organ 2011;3:29-32.
34. Mazumdar M, Chatterjee A, Majumdar S, Chandrika M, Patki PS. Evaluation of the safety and efficacy of complete care herbal toothpaste in controlling dental plaque, gingival bleeding and periodontal diseases. J Homeop Ayurv Med 2013;2:124.
35. Dye BA, Kruszon-Moran D, McQuillan G. The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States. Am J Public Health 2002;92:1809-15.
36. Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, et al. High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J Periodontol 2003;74:129-34.
37. Gebara EC, Pannuti C, Faria CM, Chehter L, Mayer MP, Lima LA. Prevalence of Helicobacter pylori detected by polymerase chain reaction in the oral cavity of periodontitis patients. Oral Microbiol Immunol 2004;19:277-80.
38. Riggio MP, Lennon A. Identification by PCR of Helicobacter pylori in subgingival plaque of adult periodontitis patients. J Med Microbiol 1999;48:317-22.
39. Hajimahmoodi M, Shams-Ardakani M, Saniee P, Siavoshi F, Mehrabani M, Hosseinzadeh H, et al. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori. Nat Prod Res 2011;25:1059-66.
40. El-Sherbini GT, Shoukry NM. In vitro effect of pomegranate peel extract on Trichomonas tenax. Life Sci J 2012;9:791-7.
41. Nema N, Arjariya S, Bairagi S, Jha M, Kharya MD. In vivo topical wound healing activity of Punica granatum peel extracts on rats. American Journal of Phytomedicine and Clinical Therapeutics 2013;1:195-200.
42. Singer AJ, Clark RA. Cutaneous wound healing. N Eng J Med 1999;341:738-46.
43. Yan H, Peng KJ, Wang QL, Gu ZY, Lu YQ, Zhao J, et al. Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan-induced diabetic rats. Chin Med J (Engl) 2013;126:1700-6.
44. Hayouni EA, Miled K, Boubaker S, Bellasfar Z, Abedrabba M, Iwaski H, et al. Hydroalcoholic extract based-ointment form Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine 2011;18:976-84.
45. Morgan C, Nigam Y. Naturally derived factors and their role in the promotion of angiogenesis for the healing of chronic wounds. Angiogenesis 2013;16:493-502.
46. Quirynen M, Teughels W, Haake SK, Newman MG. Microbiology of Periodontal Diseases. In: Giannobile WV, editor. Carranza clinical periodontology. 10 th ed. Missouri, W.B. Saunders Company; 2006. p. 134-69.
47. Howell AB, D'Souza DH. The Pomegranate: Effects on bacteria and viruses that influence human health. Evid Based Complement Alternat Med 2013;2013:606212.
48. Koh KH, Tham FY. Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. J Microbiol Immunol Infect 2011;44:144-8.
49. Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira D. The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int J Food Microbiol 2010;140:175-82.
50. Stamatova I, Meurman JH. Probiotics and periodontal disease. Periodontol 2000 2009;51:141-51.
51. Twetman S, Derawi B, Keller M, Ekstrand K, Yucel-Lindberg T, Stecksen-Blicks C. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontol Scand 2009;67:19-24.
52. Staab B, Eick S, Knöfler G, Jentsch H. The influence of probiotic milk drink on the development of gingivitis: A pilot study. J Clin Periodontol 2009;36:850-6.
53. Stamatova I, Meurman JH. Probiotics: Health benefits in the mouth. Am J Dent 2009;22:329-38.
54. Braga LC, Leite AA, Xavier KG, Takahashi JA, Bemquerer MP, Chartone-Souza E, et al. Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus. Can J Microbiol 2005;51:541-7.
55. Dey D, Debnath S, Hazra S, Ghosh S, Ray R, Hazra B. Pomegranate pericarp extract enhances the antibacterial activity of ciprofloxacin against extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL) producing gram-negative bacilli. Food Chem Toxicol 2012;50:4302-9.
56. Ghalayani P, Zolfaghary B, Farhad AR, Tavangar A, Soleymani B. The efficacy of Punica granatum extract in the management of reccurent apthous stomatitis. J Res Pharm Pract 2013;2:88-92.
57. Hekmatian E, Shadmehr E, Asghari G. Effect of pomegranate peel extract lozenge on gag reflex in dental patients. Journal of Isfahan Dental School 2011;7:229-35.
58. Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses 2003;46:192-6.
59. de Oliveira JR, de Castro VC, das Gracas Figueiredo Vilela P, Camargo SE, Carvalho CA, Jorge AO, et al. Cytotoxicity of Brazilian plant extracts against oral microorganisms of interest to dentistry. BMC Complement Altern Med 2013;13:208.
60. Vasconcelos LC, Sampaio FC, Sampaio MC, Pereira Mdo S, Higino JS, Peixoto MH. Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S.mutans, S.mitis and C. albicans. Braz Dent J 2006;17:223-7.
61. Subramaniam P, Dwivedi S, Uma E, Girish Babu KL. Effect of pomegranate and aloe vera extract on streptococcus mutans: An in vitro study. Dent Hypotheses 2012;3:99-105.
62. Viladomiu M, Hontecillas R, Lu P, Bassaganya-Riera J. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. Evid Based Complement Alternat Med 2013;2013:789764.
63. Nagata M, Hidaka M, Sekiya H, Kawano Y, Yamasaki K, Okumura M, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5.
64. Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, et al. Effects of pomegranate juice on human cytochrome P450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8.
65. Faria A, Monteiro R, Azevedo I, Calhau C. Pomegranate juice effects on cytochrome P450S expression: In vivo studies. J Med Food 2007;10:643-9.