-
1
-
-
2042534735
-
Telomere length homeostasis is achieved via a switch between telomeraseextendible and-nonextendible states
-
Teixeira MT, Arneric M, Sperisen P, et al. Telomere length homeostasis is achieved via a switch between telomeraseextendible and-nonextendible states. Cell 2004;117:323.
-
(2004)
Cell
, vol.117
, pp. 323
-
-
Teixeira, M.T.1
Arneric, M.2
Sperisen, P.3
-
2
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M, Dunlop MG, et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990;346:86.
-
(1990)
Nature
, vol.346
, pp. 86
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
-
3
-
-
0026735646
-
Telomere endreplication problem and cell aging
-
Levy MZ, Allsopp RC, Futcher AB, et al. Telomere endreplication problem and cell aging. J Mol Biol 1992;225: 951.
-
(1992)
J Mol Biol
, vol.225
, pp. 951
-
-
Levy, M.Z.1
Allsopp, R.C.2
Futcher, A.B.3
-
4
-
-
0842346436
-
Beginning to understand the end of the chromosome
-
Cech TR. Beginning to understand the end of the chromosome. Cell 2004;116:273.
-
(2004)
Cell
, vol.116
, pp. 273
-
-
Cech, T.R.1
-
5
-
-
56649115881
-
Epigenetic regulation of telomeres in human cancer
-
Vera E, Canela A, Fraga MF, et al. Epigenetic regulation of telomeres in human cancer. Oncogene 2008;27:6817.
-
(2008)
Oncogene
, vol.27
, pp. 6817
-
-
Vera, E.1
Canela, A.2
Fraga, M.F.3
-
6
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011.
-
(1994)
Science
, vol.266
, pp. 2011
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
-
7
-
-
33745679352
-
Telomerase therapeutics for cancer: Challenges and new directions
-
Shay JW, Wright WE. Telomerase therapeutics for cancer: Challenges and new directions. Nat Rev Drug Discov 2006; 5:577.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 577
-
-
Shay, J.W.1
Wright, W.E.2
-
9
-
-
33947317206
-
The epigenetic regulation of mammalian telomeres
-
Blasco MA. The epigenetic regulation of mammalian telomeres. Nat Rev Genet 2007;8:299.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 299
-
-
Blasco, M.A.1
-
10
-
-
49749139661
-
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
-
Kyo S, Takakura M, Fujiwara T, et al. Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci 2008;99:1528.
-
(2008)
Cancer Sci
, vol.99
, pp. 1528
-
-
Kyo, S.1
Takakura, M.2
Fujiwara, T.3
-
11
-
-
5444238109
-
Genetic and epigenetic modulation of telomerase activity in development and disease
-
Liu L, Lai S, Andrews LG, et al. Genetic and epigenetic modulation of telomerase activity in development and disease. Gene 2004;340:1.
-
(2004)
Gene
, vol.340
, pp. 1
-
-
Liu, L.1
Lai, S.2
Andrews, L.G.3
-
12
-
-
0041630614
-
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells
-
Lopatina NG, Poole JC, Saldanha SN, et al. Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. Biochem Biophys Res Commun 2003;306:650.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 650
-
-
Lopatina, N.G.1
Poole, J.C.2
Saldanha, S.N.3
-
13
-
-
46049103996
-
Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
-
Kikuno N, Shiina H, Urakami S, et al. Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. Int J Cancer 2008; 123:552.
-
(2008)
Int J Cancer
, vol.123
, pp. 552
-
-
Kikuno, N.1
Shiina, H.2
Urakami, S.3
-
14
-
-
77955352742
-
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
-
Meeran SM, Patel SN, Tollefsbol TO. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One 2010;5:e11457.
-
(2010)
PLoS One
, vol.5
, pp. e11457
-
-
Meeran, S.M.1
Patel, S.N.2
Tollefsbol, T.O.3
-
15
-
-
0033953573
-
Methylation of the human telomerase gene CpG island
-
Dessain SK, Yu H, Reddel RR, et al. Methylation of the human telomerase gene CpG island. Cancer Res 2000; 60:537.
-
(2000)
Cancer Res
, vol.60
, pp. 537
-
-
Dessain, S.K.1
Yu, H.2
Reddel, R.R.3
-
16
-
-
84861661655
-
Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death
-
Pettigrew KA, Armstrong RN, Colyer HA, et al. Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death. Genes Chromosomes Cancer 2012;51:768.
-
(2012)
Genes Chromosomes Cancer
, vol.51
, pp. 768
-
-
Pettigrew, K.A.1
Armstrong, R.N.2
Colyer, H.A.3
-
17
-
-
3342913667
-
Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation
-
Liu L, Saldanha SN, Pate MS, et al. Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation. Genes Chromosomes Cancer 2004;41:26.
-
(2004)
Genes Chromosomes Cancer
, vol.41
, pp. 26
-
-
Liu, L.1
Saldanha, S.N.2
Pate, M.S.3
-
18
-
-
79955399989
-
Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
-
Hutajulu SH, Indrasari SR, Indrawati LP, et al. Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population. Mol Cancer 2011;10:48.
-
(2011)
Mol Cancer
, vol.10
, pp. 48
-
-
Hutajulu, S.H.1
Indrasari, S.R.2
Indrawati, L.P.3
-
20
-
-
0017816107
-
An epidemiologic and clinical study of nasopharyngeal carcinoma
-
Ho JH. An epidemiologic and clinical study of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1978;4: 182.
-
(1978)
Int J Radiat Oncol Biol Phys
, vol.4
, pp. 182
-
-
Ho, J.H.1
-
21
-
-
0037455826
-
Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20-year period (1980-99): An encouraging reduction in both incidence and mortality
-
Lee WM, Foo W, Mang O, et al. Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20-year period (1980-99): An encouraging reduction in both incidence and mortality. Int J Cancer 2003;103: 680.
-
(2003)
Int J Cancer
, vol.103
, pp. 680
-
-
Lee, W.M.1
Foo, W.2
Mang, O.3
-
22
-
-
0036433743
-
Genetic and epigenetic changes in nasopharyngeal carcinoma
-
Lo KW, Huang DP. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002;12: 451.
-
(2002)
Semin Cancer Biol
, vol.12
, pp. 451
-
-
Lo, K.W.1
Huang, D.P.2
-
23
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007;128:683.
-
(2007)
Cell
, vol.128
, pp. 683
-
-
Jones, P.A.1
Baylin, S.B.2
-
24
-
-
47549106723
-
Nasopharyngeal carcinoma- review of the molecular mechanisms of tumorigenesis
-
Chou J, Lin YC, Kim J, et al. Nasopharyngeal carcinoma- review of the molecular mechanisms of tumorigenesis. Head Neck 2008;30:946.
-
(2008)
Head Neck
, vol.30
, pp. 946
-
-
Chou, J.1
Lin, Y.C.2
Kim, J.3
-
25
-
-
34548631786
-
Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments
-
Tao Q, Chan AT. Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments. Expert Rev Mol Med 2007;9:1.
-
(2007)
Expert Rev Mol Med
, vol.9
, pp. 1
-
-
Tao, Q.1
Chan, A.T.2
-
26
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415
-
-
Jones, P.A.1
Baylin, S.B.2
-
27
-
-
0041861033
-
Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine
-
Enright BP, Kubota C, Yang X, et al. Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. Biol Reprod 2003;69:896.
-
(2003)
Biol Reprod
, vol.69
, pp. 896
-
-
Enright, B.P.1
Kubota, C.2
Yang, X.3
-
28
-
-
67449084948
-
Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms
-
Li Y, Liu L, Andrews LG, et al. Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int J Cancer 2009;125:286.
-
(2009)
Int J Cancer
, vol.125
, pp. 286
-
-
Li, Y.1
Liu, L.2
Andrews, L.G.3
-
29
-
-
0036142690
-
CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia
-
Bechter OE, Eisterer W, Dlaska M, et al. CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia. Exp Hematol 2002;30:26.
-
(2002)
Exp Hematol
, vol.30
, pp. 26
-
-
Bechter, O.E.1
Eisterer, W.2
Dlaska, M.3
-
30
-
-
0141788590
-
Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres
-
Guilleret I, Benhattar J. Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres. Exp Cell Res 2003;289:326.
-
(2003)
Exp Cell Res
, vol.289
, pp. 326
-
-
Guilleret, I.1
Benhattar, J.2
-
31
-
-
0033082526
-
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
-
Takakura M, Kyo S, Kanaya T, et al. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999;59:551.
-
(1999)
Cancer Res
, vol.59
, pp. 551
-
-
Takakura, M.1
Kyo, S.2
Kanaya, T.3
-
32
-
-
34047137148
-
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
-
Renaud S, Loukinov D, Abdullaev Z, et al. Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res 2007;35:1245.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 1245
-
-
Renaud, S.1
Loukinov, D.2
Abdullaev, Z.3
-
33
-
-
0034644120
-
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
-
Kanduri C, Pant V, Loukinov D, et al. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol 2000;10:853.
-
(2000)
Curr Biol
, vol.10
, pp. 853
-
-
Kanduri, C.1
Pant, V.2
Loukinov, D.3
-
34
-
-
16844379244
-
Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells
-
Kumakura S, Tsutsui TW, Yagisawa J, et al. Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. Cancer Res 2005;65:2778.
-
(2005)
Cancer Res
, vol.65
, pp. 2778
-
-
Kumakura, S.1
Tsutsui, T.W.2
Yagisawa, J.3
-
35
-
-
33846422373
-
HTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site
-
Zinn RL, Pruitt K, Eguchi S, et al. HTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Res 2007;67:194.
-
(2007)
Cancer Res
, vol.67
, pp. 194
-
-
Zinn, R.L.1
Pruitt, K.2
Eguchi, S.3
-
36
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995;269:1236.
-
(1995)
Science
, vol.269
, pp. 1236
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
-
37
-
-
59249101446
-
Short telomeres initiate telomere recombination in primary and tumor cells
-
Morrish TA, Greider CW. Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet 2009;5:e1000357.
-
(2009)
PLoS Genet
, vol.5
, pp. e1000357
-
-
Morrish, T.A.1
Greider, C.W.2
|