Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 375-382

  Schuck, Desirée C ^a   Jordão, Alessandro K ^b,c   Nakabashi, Myna ^a   Cunha, Anna C ^b   Ferreira, Vitor F ^b   Garcia, Célia R S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c Centro Universitario Estadual da Zona Oeste   (Brazil)

Author keywords

Antimalarial; Indole derivatives; Malaria; Melatonin; Melatonin analogs; Plasmodium falciparum; Tryptamine analogs

Indexed keywords

ANTIMALARIAL AGENT; INDOLE DERIVATIVE; MELATONIN DERIVATIVE; METHYL [2 (5 METHOXY 1H INDOL 3 YL)ETHYL]CARBAMATE; N [2 (1H INDOL 3 YL)ETHYL]ACETAMIDE; N [2 (1H INDOL 3 YL)ETHYL]BENZAMIDE; N [2 (1H INDOL 3 YL)ETHYL]BUTANAMIDE; N [2 (1H INDOL 3 YL)ETHYL]HEXANAMIDE; N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL]BENZAMIDE; N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL]BUTANAMIDE; N [2 (5 METHOXY 1H INDOL 3 YL)ETHYL]HEXANAMIDE; UNCLASSIFIED DRUG; MELATONIN;

ANIMAL CELL; ANOPHELES; ANTIMALARIAL ACTIVITY; ARTICLE; CELL CYCLE; CELL CYCLE PROGRESSION; CHEMICAL MODIFICATION; COMPARATIVE STUDY; DRUG SYNTHESIS; IC 50; MELANOPHORE; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; RECEPTOR BINDING; XENOPUS LAEVIS; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; GROWTH, DEVELOPMENT AND AGING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIMALARIALS; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MELATONIN; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906986127     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.055     Document Type: Article

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