Melatonin effects on Plasmodium life cycle: New avenues for therapeutic approach

Recent Patents on Endocrine, Metabolic and Immune Drug Discovery

Volumn 6, Issue 2, 2012, Pages 139-147

  Srinivasan, Venkataramanujam ^a   Ahmad, Asma H ^b   Mohamed, Mahaneem ^b   Zakaria, Rahimah ^b  

^a Sri Sathya Sai Medical Educational and Research Foundation   (India)

^b SCHOOL OF MEDICAL SCIENCES   (Malaysia)

Author keywords

Anti malarial drugs; Bright light therapy; Luzindole; Malaria; Melatonin; Plasmodium falciparum

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 AMINOETHYLDIPHENYLBORINATE; ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE; FASUDIL; GENISTEIN TRYPHOSTIN; HORMONE ANTAGONIST; IMATINIB; IMIDAZOLE DERIVATIVE; LUZINDOLE; MELATONIN; MELATONIN ANTAGONIST; MELATONIN RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE INHIBITOR; PROTEINASE; RAPAMYCIN; THAPSIGARGIN; TRIAZOLIUM DERIVATIVE; UBIQUITIN PROTEASE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CIRCADIAN RHYTHM; DRUG MECHANISM; ENZYME ACTIVATION; GROWTH REGULATION; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HUMAN; LIFE CYCLE; MALARIA; MALARIA CONTROL; NONHUMAN; PARASITE DEVELOPMENT; PHOTOTHERAPY; PLASMODIUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VECTOR CONTROL;

EID: 84861785681     PISSN: 18722148     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221412800604635     Document Type: Article

References (75)

1. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005; 434(7030): 214-7
2. Breman JG. Eradicating malaria. Sci Prog 2009; 92: 1-38
3. Murray CJ, Rosenfield LC, Lim SS, Andrews KG, Foreman KG, Haring D, et al. Global malaria mortality between 1980 and 2010: A systematic analysis. Lancet 2012; 379(9814): 413-31
4. World Malaria report 2005. Available at: http://rbm.who.int/wmr2005/ (Assessed on: January 31, 2012)
5. Ministry of Health (MOH) Annual report, Putra Jaya, Ministry of Health, Malaysia, 2008
6. Rohani A, Chu WL, Zamree I, Abdullah AG, Saadiyah I, Lee HL, et al. Microalgae associated with mosquito breeding grounds in Malaysia. Tropical Bio Med 2002; 19: 83-96
7. Rohani A, Wan Najdah WMA, Zamree I, Azahari AH, Mohd Noor I, Rahimi H, et al. Characterization and mapping of Anopheles maculates (Theobald) larvae in malaria endemic areas in Kuala Lipis, Pahang, Malaysia. South East Asian J Trop Med Pub Health 2010; 41: 821-30
8. Rohani A, Wan Najdah WMA, Zurainee M, Zamree I, Azahari AH, Ibrahim M, et al. Mapping of mosquito breeding sites in malaria endemic areas in Pos Lenjang, Kuala lipis, Pahang, Malaysia. Malar J 2011; 10: 361
9. Skinner-Adams TS, Stack CM, Trenholme KR, Brown CI, Grembecka J, Lowther J, et al. Plasmodium falciparum neutral amino peptidases: New targets for anti malarials. Trends Biochem Sci 2010; 35(1): 53-61
10. Kappe SH, Vaughen SM, Boddey JA, Cowman AF. That was then but this now. Malaria research in the time of an eradication agenda. Science 2010; 328(5980): 862-6
11. Kooij TW, Janse CJ, Waters AP. Plasmodium post genomics: better the bug you know. Nat Rev Microbiol 2006; 4(5): 344-57
12. Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar Kumar S, et al. Signalling in malarial parasites. The MALSIG Consortium. Parasite 2009; 16(3): 169-82
13. Singh S, Alam MM, Pal-Bhowmick I, Brzostowski JA, Chitnis CE. Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by Malaria parasites. PLos Pathol 2010; 6(2): e 1000746
14. Hotta CT, Gazarini ML, Beraldo FH, Varotti FP, Lopes C, Markus RP, et al. Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites. Nat Cell Biol 2000; 2: 466-8
15. Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 2004; 25: 177-95
16. Tricoire H, Locatelli A, Chemineau P, Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002; 143: 84-90
17. Carrillo-Vico A, Calvo JR, Abreu P, Lardone PJ, Garcia-Maurino S, Reiter RJ, et al. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: Possible role as intracrine, autocrine, and/or paracrine substance. FASEB J 2004; 18: 537-9
18. Naranjo MC, Guerrero JM, Rubio A, Lardone PJ, Carrillo-Vico A, Carrascosa-Salmoral MP, et al. Melatonin biosynthesis in the thymus of humans and rats. Cell Mol Life Sci 2007; 64: 781-90
19. Slominiski A, Wortsman J, Tobin DJ. The cutaneous serotonergic/ melatonergic system. FASEB J 2005; 19: 176-94
20. Ribelayga C, Pevet P, Simonneaux V. HIOMT drives the photoperiodic changes in the amplitude of melatonin peak of the Siberian hamster. Am J Physiol Regul Integr Comp Physiol 2000; 278(5): R1339-45
21. Ceinos RM, Chansard M, Revel F, Calgari C, Míguez JM, Simonneaux V. Analysis of adrenergic regulation of melatonin synthesis in Siberian hamster pineal emphasizes the role of HIOMT. Neurosignals 2004; 13: 308-17
22. Moore RY. Vision without sight. N Eng J Med Med 1995; 332: 54-5
23. Berson DM, Dunn FA, Takao M. Photo transduction by retinal ganglion cells that set the circadian clock. Science 2002; 295: 1070-3
24. Moore RY. Neural control of the pineal gland. Behave Brain Res 1996; 73:125-30
25. Ackermann K, Stehle JH. Melatonin synthesis in the human pineal gland: Advantages, implications and difficulties. Chronobiol Int 2006; 23: 369-79
26. Ganguly S, Weller JL, Ho A. Melatonin synthesis: 14-3-3-ependent activation of and inhibition of arylalkylamine Nacetyltransferase mediated by phosphor-serine. Proc Natl Acad Sci USA 2005; 102: 1222-7
27. Gastel JA, Roseboom PH, Rinaldi PA, Weller JL, Klein DC. Melatonin production: Proteosomal proteolysis in serotonin Nacetyltransferase regulation. Science 1998; 279: 1358-60
28. Hirata F, Hayaishi O, Tokuyama T, Seno S. In vitro and formation of two new metabolites of melatonin. J Biol Chem 1974; 249: 1311-3
29. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never ending interaction of melatonin with reactive oxygen and nitrogen species. J Pineal Res 2007; 42: 28-42
30. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994; 13: 1177-85
31. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaughenhaupt SA, Gusella JF. Molecular characterization of a second mammalian receptor expressed in human retina and brain. Proc Natl Acad Sci USA 1995; 92: 8734-8
32. Nosjean O, Ferro O, Coge F, Beauverger P, Henlin JM, Lefoulon F, et al. Identification of the melatonin binding site MT3 as quinine reductase 2. J Biol Rhythms 2000; 275: 31311-7
33. Wiesenberg I, Missbach M, Carlberg C. The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signalling. Restor Neurol Neuroosci 1998; 12: 143-50
34. Godson C, Reppert SM. The Mel1a melatonin receptor is coupled to parallel signal transduction pathways. Endocrinology 1997; 138: 397-404
35. Brydon L, Roka F, Petit L, deCoppet P, Tissot M, Barren P, et al. Dual signalling of human Mel 1A melatonin receptors via Gi2, Gi3, Gq/11 proteins. Mol Endocrinol 1999; 13: 2025-38
36. Benitez-King G, Rios A, Martinez A, Anton-Tay F. In vitro inhibition of Ca2+/calmodulin dependent kinase II activity by melatonin. Biochem Biophys Acta 1996; 1290: 191-6
37. Anton-Tay F, Ramirez G, Martinez I, Benitez-King G. In vitro stimulation of protein kinase C by melatonin. Neurochem Res 1998; 23: 601-6
38. Macias M, Escames G, Leon J, Coto A, Shibi Y, Osuna A, et al. Calreticulin-melatonin:an unexpected relationship. Eur J Biochem 2003; 270: 832-40
39. Dubocovich ML. Luzindole (N-0774), a novel melatonin receptor antagonist. J Pharmacol Exp Ther 1988; 246: 902-10
40. Arnold JD, Berger A, Martin DC. The role of the pineal in mediating photo-periodic control of growth and division synchrony and capillary sequestration of Plasmodium berghei in mice. J Parasitol 1969; 55(3): 609-16
41. Gratzer WB, Dluzewski AR. The red blood cell and malaria parasite invasion. Semin Hematol 1993; 30: 232-47
42. Aly AS, Vaughan AM, Kappe SH. Malaria parasite development in the mosquito infection of the mammalian host. Ann Rev Microbiol 2009; 63: 195-221
43. Aravind L, Iyer LM, Wellems TE, Miller LH. Plasmodium biology: Genomic gleanings. Cell 2003; 115: 771-85
44. Garnham PC, Powers KG. Periodicity of infectivity of plasmodial gametocytes: The "Hawking phenomena". Int J Parasitol 1974; 4: 103-6
45. Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 2002; 419: 520-6
46. Beraldo FH, Almeida FM, da Silva AM, Garcia CR. Cyclic AMP and Calcium interplay as second messengers in melatonin dependent regulation of Plasmodium falciparum cell cycle. J Cell Biol 2005; 170: 551-7
47. Jockers R, Maurice P, Boutin JA, Delagrange P. Melatonin receptors, heterodimerization, signal transduction and binding sites. Brit J Pharmacol 2008; 154: 1182-95
48. Gazarini ML, Beraldo FH, Almeida FM, Bootman M, de silva AM, Garcia CRS. Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi. J Pineal Res 2011; 50: 64-70
49. Varotti FP, Beraldo FH, Gazarini MI, Garcia CR. Plasmodium falciparum malaria display THG sensitive Ca2+ pool. Cell Calcium 2003; 33: 137-44
50. Nagamune K, Sibley LD. Competitive genomic and phylogenetic analysis of calcium ATPases and calcium regulated proteins in the apicomplexa. Mol Bio Evol 2006; 23: 1613-27
51. Alves E, Barlett PJ, Garcia CRS, Thomas AP. Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells. J Biol Chem 2010; 286(7): 5905-12
52. Madeira L, Galante PAF, Budu A, Azevedo MF, Malnic B, Garcia CRS. Genome-wide detection of serpentine receptor like proteins in malaria parasites. PLoS ONE 2008; 3(3): e1889
53. Beraldo FH, Garcia CRS. Products of tryptophan catabolism induce Ca2+ release and modulate the cell cycle of Plasmodium falciparum malaria parasites. J Pineal Res 2005; 39: 224-30
54. Budu A, Peres R, Bueno VB, Catalani LH, Garcia CRS. N1-acetyl-N2-formyl-5-methoxykynuramine modulates the cell cycle. J Pineal Res 2007; 42: 261-6
55. Macias M, Rodriguez-Cabezas MN, Reiter RJ, Osuna A, Acuna-Castroviejo D. Presence and effects of melatonin in Trypanosoma cruzi.J PinealRes 1999; 27: 86-94
56. Clark IA, Hunt NH. Evidence for reactive oxygen intermediates causing hemolysis and parasitic death in malaria. Infect Immunol 1983; 39: 1-6
57. Atamna H, Ginsburg, H. The malaria parasite supplies glutathione to its host cell-investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum. Eur J Biochem 1997; 250: 670-9
58. Koyama FL, Ribeiro RY, Garcia JL, Azevedo MF, Chakrabarti D, Garcia CR. Ubiquitin protease system and the atypical kinase PIPK7 are involved in melatonin signalling in Plasmodium falciparum. J Pineal Res 2012; doi: 1111/J 1600-079X 2012.00981x
59. Bagnaresi P, Alves A, Borges Da silva H, Epiphanio S, Mota MM, Garcia CRS. Unlike the synchronous Plasmodium falciparum and P.chabaudi infection, the P.bergheia and P.yoelli asynchronous infections are not affected by melatonin. Int J Gen Med 2009; 2: 47-55
60. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science 1980; 210: 1267-9
61. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Rosenthal NE. Manic-depressive patients may be supersensitive to light. Lancet 1981; 1(8216): 383-4
62. Ando K, Kripke DF, Cole RJ, Elliott JA. Light mask 500 lux treatment for delayed sleep phase syndrome. Prog Neuro-sychopharmacol Biol Psychiat 1999; 23: 15-24
63. Lewy AJ, Sack RL, Singer M. Bright light, melatonin and winter depression: The phase-shift hypothesis. In: Mohammad Shafii and Sharon Lee Shafii, Eds. Biological rhythms, mood disorders, light therapy and the pineal gland. Washington DC: American Psychiatric Press 1990; 143-73
64. Wehr TA, Aeschbach D, Duncan Jr WC. Evidence for a biological dawn and dusk in the human circadian timing system. J Physiol 2001; 535: 937-51
65. Sack RL. Host melatonin secretion is a timing signal for the release of W. bancrofti microfilaria into the circulation. Med Hypotheses 2009; 73: 147-9
66. Madeira, L, Demarco R, Gazarini, ML, Verjovski-Almeida S, Garcia CR. Human malaria parasites display a receptor for activated C kinase ortholog. Biochem Biophys Res Commun 2003; 306: 995-1001
67. Cohen P. Protein kinases-the major drug targets of the twenty first century. Nat Rev Drug Discov 2002; 1: 309-15
68. Gazarini ML, Garcia CR, Interruption of the blood stage cycle of malaria parasite. Plasmodium chabaudi by protein tyrosine kinase inhibitors. Braz J Med Biol Res 2003; 36: 1465
69. Garcia, C.R.S., Malnic, B., da Silva, L.M., Favoretto, P.A. Pharmateutical composition, drug, screening method for treating malaria. US20120053117 (2012)
70. Colbaugh, M.E., Timothy, A. System and method for delivering electromagnetic radiation to the eyeball of a subject. US20120041520 (2012)
71. Crandall, I.E., Szarek, W.A., Viahakis, J.Z. Triazolium and imidazolium salts and uses thereof. US20110257235 (2011)
72. Mazier, D., Mahmoudi, N. Compounds for preventing and treating Plasmodium infections. US 20110124723A1 (2011)
73. Heizmann, J. Pharmaceutical composition for treating malaria. US201/0008410 (2011)
74. Srinivasan V, Spence DW, Moscovitch A, Pandi-Perumal SR, Trakht I, Brown GM, et al. Malaria: Therapeutic implications. J Pineal Res 2010; 48: 1-8
75. Guha M, Maity P, Choubey V, Mitra K, Reiter RJ, Banyopadhyay U. Melatonin inhibits free radical-mediated mitochondrial dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res 2007; 43: 372-8