GlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea

Applied Microbiology and Biotechnology

Volumn 98, Issue 18, 2014, Pages 7935-7948

  Yao, Li Li ^a   Liao, Cheng Heng ^a   Huang, Gang ^a   Zhou, Ying ^a   Rigali, Sebastien ^b   Zhang, Buchang ^c   Ye, Bang Ce ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c ANHUI UNIVERSITY   (China)

Author keywords

Actinomycetes; Erythromycin; GlnR regulator; Nitrogen metabolism; Nitrogen utilization

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BIOCHEMISTRY; METABOLISM; NITRIC OXIDE; NITROGEN; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SODIUM NITRATE; TRANSCRIPTION; UREA;

ACTINOMYCETES; ERYTHROMYCIN; GLNR REGULATOR; NITROGEN METABOLISM; NITROGEN UTILIZATION;

BACTERIA;

AMMONIA; ARGININE; BACTERIAL PROTEIN; ERYTHROMYCIN; GLNR PROTEIN; GLUTAMIC ACID; GLUTAMINE; NITRATE; NITRIC OXIDE; NITRITE; NITROGEN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; UREA; AMMONIUM CHLORIDE; NITRIC ACID DERIVATIVE; SODIUM NITRATE;

BACTERIUM; BIOASSAY; CHROMOSOME; GROWTH RATE; INOCULATION; INORGANIC COMPOUND; METABOLISM; NITROGEN; NUMERICAL MODEL; POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; COMPUTER MODEL; CONSENSUS SEQUENCE; CONTROLLED STUDY; DELETION MUTANT; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MYCOBACTERIUM SMEGMATIS; NITROGEN UTILIZATION; NONHUMAN; OPEN READING FRAME; PARALOGY; PROTEIN BINDING; REGULATORY MECHANISM; REGULON; SACCHAROPOLYSPORA; SECONDARY METABOLISM; SIGNAL TRANSDUCTION; STREPTOMYCES COELICOLOR; STREPTOMYCES ERYTHRAEUS; ACTINOBACTERIA; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM;

ACTINOBACTERIA (CLASS); SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES COELICOLOR;

ACTINOBACTERIA; AMMONIUM CHLORIDE; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GLUTAMIC ACID; GLUTAMINE; NITRATES; NITROGEN;

EID: 84906951648     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-5878-1     Document Type: Article

References (24)

1. Amin R, Reuther J, Bera A, Wohlleben W, Mast Y (2012) Novel GlnR-target gene, nnaR, is involved in nitrate/nitrite assimilation in Streptomyces coelicolor. Microbiology 158:1172-1182
2. Amon J, Brau T, Grimrath A, Hanler E, Hasselt K, Höller M, Jessberger N, Ott L, Szököl J, Titgemeyer F, Burkovski A (2008) Nitrogen control in Mycobacterium smegmatis: nitrogen-dependent expression of ammonium transport and assimilation proteins depends on the OmpR-type regulator GlnR. J Bacteriol 190:7108-7116
3. Amon J, Titgemeyer F, Burkovski A (2010) Common patterns-unique features: nitrogen metabolism and regulation in Gram-positive bacteria. FEMS Microbiol Rev 34:588-605
4. Elisabetta C, Clelia P, Salvatore MT, Francesco F, Adelfia T, Giorgio C, Silvio B, Gianluca DB, Pietro A (2009) Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production. Microb Cell Factories 8:18
5. Fink D, Weisschuh N, Reuther J, Wohlleben W, Engels A (2002) Two transcriptional regulators GlnR and GlnRII are involved in regulation of nitrogen metabolism in Streptomyces coelicolor A3(2). Mol Microbiol 46:331-347 (Pubitemid 35340947)
6. Hiard S, Marée R, Colson S, Hoskisson PA, Titgemeyer F, van Wezel GP, Joris B, Wehenkel L, Rigali S (2007) PREDetector: a new tool to identify regulatory elements in bacterial genomes. Biochem Biophys Res Commun 357:861-864 (Pubitemid 46693651)
7. Kloosterman TG, Hendriksen WT, Bijlsma JJ, Bootsma HJ, van Hijum SA, Kok J, Hermans PW, Kuipers OP (2006) Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae. J Biol Chem 281:25097-25109 (Pubitemid 44401897)
8. Li YY, Chang X, Yu WB, Li H, Ye ZQ, Yu H, Liu BH, Zhang Y, Zhang SL, Ye BC, Li YX (2013) Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains. BMC Genomics 14:523
9. Liu H, Huang XD, Liu DQ, Zhao W, Fan W, Han S, Zhang BC (2009) Rapid chromosomic gene inactivating technology of Saccharopolyspora erythraea. Bull Acad Mil Med Sci 33:365-369
10. Martín JF, Sola-Landa A, Santos-Beneit F, Fernández- Martínez LT, Prieto C, Rodríguez-García A (2011) Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces. Microbiol Biotechnol 4:165-174
11. Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF, Leadlay PF (2007) Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat Biotechnol 25:447-453 (Pubitemid 46572853)
12. Potvin J, Peringer P (1994) Ammonium regulation in Saccharopolyspora erythraea. Biotechnol Lett 16:63-68
13. Pullan ST, Chandra G, Bibb MJ, Merrick M (2011) Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes. BMC Genomics 12:175
14. Reeve M, Baumberg S (1998) Physiological controls of erythromycin production by Saccharopolyspora erythraea are exerted at least in part at the level of transcription. Biotechnol Lett 20:585-589
15. Reuther J, Wohlleben W (2007) Nitrogen metabolism in Streptomyces coelicolor: transcriptional and post-translational regulation. J Mol Microbiol Biotechnol 12:139-146 (Pubitemid 46011135)
16. Rigali S, Titgemeyer F, Barends S, Mulder S, Thomae AW, Hopwood DA, van Wezela GP (2008) Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep 9:670-675 (Pubitemid 351927688)
17. Tiffert Y, Supra P, Wurm R, Wohlleben W, Wagner R, Reuther J (2008) The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes. Mol Microbiol 67:861-880 (Pubitemid 351143689)
18. Tiffert Y, Franz-Wachtel M, Fladerer C, Nordheim A, Reuther J, Wohlleben W, Mast Y (2011) Proteomic analysis of the GlnR-mediated response to nitrogen limitation in Streptomyces coelicolor M145. Appl Microbiol Biotechnol 89:1149-1159
19. van Wezela GP, McDowall KJ (2011) The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat Prod Rep 28:1311-1333
20. Wang J, Zhao GP (2009) GlnR positively regulates nasA transcription in Streptomyces coelicolor. Biochem Biophys Res Commun 386:77-81
21. Weiss V, Kramer G, Dunnebier T, Flotho A (2002) Mechanism of regulation of the bifunctional histidine kinase NtrB in Escherichia coli. J Mol Microbiol Biotechnol 4:229-233 (Pubitemid 34256696)
22. Yoshida K, Yamaguchi H, Kinehara M, Ohki YH, Nakaura Y, Fujita Y (2003) Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box. Mol Microbiol 49:157-165 (Pubitemid 36792011)
23. Yu H, Yao Y, Liu Y, Jiao R, Jiang W, Zhao GP (2007) A complex role of Amycolatopsis mediterranei GlnR in nitrogen metabolism and related antibiotics production. Arch Microbiol 188:89-96 (Pubitemid 46919115)
24. Zou X, Hang H, Chu J, Zhuang Y, Zhang S (2009) Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase. Bioresour Technol 100:3358-3365