Modulating hydrogel crosslink density and degradation to control bone morphogenetic protein delivery and in vivo bone formation

Journal of Controlled Release

Volumn 191, Issue , 2014, Pages 63-70

  Holloway, Julianne L ^a   Ma, Henry ^a   Rai, Reena ^a   Burdick, Jason A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bone morphogenetic protein; Bone repair; Calvarial defect; Hyaluronic acid; Hydrogel

Indexed keywords

BONE; DEFECTS; DEGRADATION; GELATION; HYALURONIC ACID; ORGANIC ACIDS; PROTEINS; REPAIR; TISSUE;

BONE MORPHOGENETIC PROTEINS; BONE REPAIR; CALVARIAL DEFECTS; CROSS-LINK DENSITIES; GROWTH FACTOR RELEASE; HYDROGEL DEGRADATION; MATRIX METALLOPROTEASE; OSTEOINDUCTIVE EFFECTS;

HYDROGELS;

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN 2; GROWTH FACTOR; HYALURONIC ACID; MALEIMIDE; MATRIX METALLOPROTEINASE; PEPTIDE; COLLAGENASE; CROSS LINKING REAGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYDROGEL; MALEIMIDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MASS; BONE REMODELING; CALVARIA; CROSS LINKING; DEGRADATION; DENSITY; GELATION; HUMAN; HUMAN CELL; HYDROGEL; IN VIVO STUDY; MALE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; COMPRESSIVE STRENGTH; DELAYED RELEASE FORMULATION; DRUG EFFECTS; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; PHARMACEUTICS; PROCEDURES; RADIOGRAPHY; SKULL; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CHEMISTRY, PHARMACEUTICAL; COLLAGENASES; COMPRESSIVE STRENGTH; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HYALURONIC ACID; HYDROGELS; KINETICS; MALE; MALEIMIDES; OSTEOGENESIS; PEPTIDES; RATS, SPRAGUE-DAWLEY; SKULL; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84906946132     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.053     Document Type: Article

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