A rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia

Journal of Controlled Release

Volumn 191, Issue , 2014, Pages 47-53

  Yu, Xiaohua ^a   Takayama, Toshio ^a   Goel, Shakti A ^a   Shi, Xudong ^a   Zhou, Yifan ^a   Kent, K Craig ^a   Murphy, William L ^a   Guo, Lian Wang ^a  

^a University of Wisconsin Health   (United States)

Author keywords

Intimal hyperplasia; Open vascular surgery; Perivascular drug delivery; Ploy( caprolactone) (PCL) sheath; Rapamycin

Indexed keywords

DISEASES; KINETICS; PHYSICAL PROPERTIES; SCANNING ELECTRON MICROSCOPY; SURGERY;

BIORESORBABLE POLYMERS; CAPROLACTONE; INTIMAL HYPERPLASIA; POLY (EPSILONCAPROLACTONE); POLY-LACTIDE-CO-GLYCOLIDE; RAPAMYCIN; VASCULAR INTERVENTIONS; VASCULAR SURGERY;

POLYMERS;

CD31 ANTIGEN; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIC ACID; RAPAMYCIN; CARDIOVASCULAR AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; POLYESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY; CAROTID ARTERY THROMBOSIS; CELL PROLIFERATION; CONTROLLED STUDY; DEGRADATION; DRUG DELIVERY SYSTEM; HYDROPHOBICITY; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTIMAL HYPERPLASIA; LABORATORY; MORPHOMETRICS; NEOINTIMA; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; VASCULAR DISEASE; ANIMAL; CAROTID ARTERY INJURIES; CAROTID STENOSIS; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DISEASE MODEL; DRUG EFFECTS; KINETICS; MALE; MEDICINAL CHEMISTRY; PATHOLOGY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

ANIMALS; CARDIOVASCULAR AGENTS; CAROTID ARTERY INJURIES; CAROTID STENOSIS; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; HYPERPLASIA; KINETICS; LINEAR MODELS; MALE; NEOINTIMA; POLYESTERS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84906946123     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.017     Document Type: Article

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