In vivo evaluation of the delivery and efficacy of a sirolimus-laden polymer gel for inhibition of hyperplasia in a porcine model of arteriovenous hemodialysis graft stenosis

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 459-467

  Terry, Christi M ^a   Li, Li ^a   Li, Huan ^a   Zhuplatov, Ilya ^a   Blumenthal, Donald K ^b   Kim, Seong Eun ^a   Owen, Shawn C ^b   Kholmovski, Eugene G ^a   Fowers, Kirk D ^c   Rathi, Ramesh ^c   Cheung, Alfred K ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c BTG Company   (United States)

Author keywords

Hemodialysis vascular access; MRI; Polymer gel; Sirolimus; Stenosis; Sustained drug delivery

Indexed keywords

CAROTID ARTERY; CONTRAST TO NOISE RATIO; CONTROL GRAFTS; CROSS SECTIONAL AREA; DEGRADATION KINETICS; DRUG-DELIVERY POLYMERS; GRAFT FAILURE; HEMODIALYSIS GRAFT; HISTOLOGICAL ANALYSIS; IN-VITRO; IN-VIVO; JUGULAR VEINS; MR IMAGES; NON-INVASIVE MONITORING; POLYMER GELS; PORCINE MODELS; PULSE SEQUENCE; SIROLIMUS; STENOSIS; SURFACE AREA; SYNTHETIC GRAFTS; VASCULAR ACCESS; VISUAL ASSESSMENTS;

DEGRADATION; DIALYSIS; DRUG DELIVERY; MAGNETIC RESONANCE IMAGING; RATING; SURGERY; TISSUE;

HEMODIALYZERS;

POLYMER; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HEMODIALYSIS; HYPERPLASIA; IN VIVO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STENOSIS; SWINE; VEIN ANASTOMOSIS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DRUG CARRIERS; GELS; GRAFT OCCLUSION, VASCULAR; HYPERPLASIA; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; RENAL DIALYSIS; SIROLIMUS; SUS SCROFA;

EID: 84861971094     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.011     Document Type: Article

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