Elderly patients aged 65-75 years with glioblastoma multiforme may benefit from long course radiation therapy with temozolomide

Journal of Neuro-Oncology

Volumn 119, Issue 1, 2014, Pages 187-196

  Gzell, C ^a,b   Wheeler, H ^a,b   Guo, L ^a   Kastelan, M ^a   Back, M ^a,b  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Elderly; GBM; Glioblastoma; Glioma; Survival

Indexed keywords

TEMOZOLOMIDE; ALKYLATING AGENT; DACARBAZINE;

AGED; ARTICLE; BRAIN HEMORRHAGE; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CEREBROVASCULAR ACCIDENT; CHEMORADIOTHERAPY; CONTROLLED STUDY; DISEASE COURSE; DRUG HYPERSENSITIVITY; ELDERLY CARE; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; INTENSITY MODULATED RADIATION THERAPY; INTRACRANIAL HYPERTENSION; LONG COURSE RADIATION THERAPY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEGAVOLTAGE RADIOTHERAPY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PANCYTOPENIA; PATIENT COMPLIANCE; PATIENT MOBILITY; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; SURVIVAL PREDICTION; SURVIVAL TIME; THROMBOEMBOLIC STROKE; TREATMENT DURATION; TUMOR BIOPSY; AGE; ANALOGS AND DERIVATIVES; BRAIN NEOPLASMS; DISEASE FREE SURVIVAL; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PROGNOSIS; TREATMENT OUTCOME; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; DACARBAZINE; DISEASE-FREE SURVIVAL; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84906940254     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-014-1472-8     Document Type: Article

References (29)

1. Australian Institute of Health and Welfare (2012) Cancer survival and prevalence in Australia: period estimates from 1982 to 2010 [Internet]. http://www.aihw.gov.au/WorkArea/DownloadAsset.aspx?id=10737422721
2. Chandana SR, Movva S, Arora M, Singh T (2008) Primary brain tumors in adults. Am Fam Physician 77(10):1423-1430
3. Dobes M, Khurana VG, Shadbolt B, Jain S, Smith SF, Smee R et al (2011) Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): findings of a multicenter Australian study. Surg Neurol Int 2:176
4. De Robles P, Cairncross G (2008) Glioblastoma in the elderly: an age-old problem. Ann Neurol 64(6):597-599
5. Wrensch M, Minn Y, Chew T, Bondy M, Berger MS (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 4(4):278-299
6. Minniti G, Sanctis V, Muni R, Rasio D, Lanzetta G, Bozzao A et al (2008) Hypofractionated radiotherapy followed by adjuvant chemotherapy with temozolomide in elderly patients with glioblastoma. J Neurooncol 91(1):95-100
7. Laperriere N, Weller M, Stupp R, Perry JR, Brandes AA, Wick W, et al. Optimal management of elderly patients with glioblastoma. Cancer Treat Rev [Internet]. [cited 2012 Nov 1];(0). http://www.sciencedirect.com/science/ article/pii/S0305737212001338
8. Hashem SA, Salem A, Al-Rashdan A, Ezam N, Nour A, Alsharbaji A et al (2012) Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme. J Med Imaging Radiat Oncol 56(2):204-210
9. Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD (2003) Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97(9):2262-2266 (Pubitemid 36444070)
10. Tanaka S, Meyer FB, Buckner JC, Uhm JH, Yan ES, Parney IF (2013) Presentation,management, and outcome of newly diagnosed glioblastoma in elderly patients. J Neurosurg 118(4):786-798
11. Chinot O-L, Barrie M, Frauger E, Dufour H, Figarella-Branger D, Palmari J et al (2004) Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer 100(10):2208-2214 (Pubitemid 38580342)
12. Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M et al (2012) Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol 13(7):707-715
13. Malmström A, Grønberg BH, Marosi C, Stupp R, Frappaz D, Schultz H et al (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol 13(9):916-926
14. Barnholtz-Sloan JS, Williams VL, Maldonado JL, Shahani D, Stockwell HG, Chamberlain M et al (2008) Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma. J Neurosurg 108(4):642-648 (Pubitemid 351498955)
15. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, Janzer RC et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459-466
16. Iwamoto FM, Reiner AS, Panageas KS, Elkin EB, Abrey LE (2008) Patterns of care in elderly glioblastoma patients. Ann Neurol 64(6):628-634
17. Minniti G, Sanctis V, Muni R, Filippone F, Bozzao A, Valeriani M et al (2008) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 88(1):97-103
18. Roa W, Brasher PMA, Bauman G, Anthes M, Bruera E, Chan A et al (2004) Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol 22(9):1583-1588 (Pubitemid 41079795)
19. Combs SE, Wagner J, Bischof M, Welzel T, Wagner F, Debus J et al (2008) Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int J Radiat Oncol 70(4):987-992 (Pubitemid 351296114)
20. Sijben AE, McIntyre JB, Roldán GB, Easaw JC, Yan E, Forsyth PA et al (2008) Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol 89(1):97-103
21. Rosenthal MA, Drummond KJ, Dally M, Murphy M et al (2006) Management of glioma in Victoria (1998-2000): retrospective cohort study. Med J Aust 184(6):270-273
22. Behm T, Horowski A, Schneider S, Bock HC, Mielke D, Rohde V et al (2013) Concomitant and adjuvant temozolomide of newly diagnosed glioblastoma in elderly patients. Clin Neurol Neurosurg 115(10):2142-2146
23. Cher L, Rosenthal MA, Drummond KJ, Dally M, Murphy M, Ashley D et al (2008) The use of chemotherapy in patients with gliomas: patterns of care in Victoria from 1998-2000. J Clin Neurosci Off J Neurosurg Soc Australas 15(4):398-401
24. Brandes AA, Vastola F, Basso U, Berti F, Pinna G, Rotilio A et al (2003) A prospective study on glioblastoma in the elderly. Cancer 97(3):657-662 (Pubitemid 36125843)
25. National Cancer Institute. Common Terminology Criteria for Adverse Events v 3.0 (CTCAE) [Internet] (2006). http://ctep.cancer.gov/protocolDevelopment/ electronic-applications/docs/ctcaev3.pdf
26. Vuorinen V, Hinkka S, Färkkilä M, Jääskeläinen J (2003) Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir (Wien) 145(1):5-10 (Pubitemid 36174074)
27. Sher DJ, Henson JW, Avutu B, Hochberg FH, Batchelor TT, Martuza RL et al (2008) The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma. J Neuro Oncol 88(1):43-50
28. Stummer W, Nestler U, Stockhammer F, Krex D, Kern BC, Mehdorn HM et al (2011) Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA. J Neurooncol 103(2):361-370
29. Heros DO, Heros RC (2013) Editorial: glioblastoma in the elderly. J Neurosurg 118(4):783-785 discussion 784-785